prikaz prve stranice dokumenta N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset
  Download
PDF 1.28 MB
Scientific paper - Original scientific paper
N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset
Clinica Chimica Acta, 543 (2023); 117298. https://doi.org/10.1016/j.cca.2023.117298
Nemčić, Matej; Tijardović, Marko; Rudman, Najda; Bulum, Tomislav; Tomić, Martina; Plavša, Branimir; Vučković Rebrina, Sandra; Vučić Lovrenčić, Marijana; Duvnjak, Lea; Morahan, Grant; Gornik, Olga

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Nemčić, M., Tijardović, M., Rudman, N., Bulum, T., Tomić, M., Plavša, B. ... Gornik, O. (2023). N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset. Clinica Chimica Acta, 543.. doi: 10.1016/j.cca.2023.117298

Nemčić, Matej, et al. "N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset." Clinica Chimica Acta, vol. 543, 2023. https://doi.org/10.1016/j.cca.2023.117298

Nemčić, Matej, Marko Tijardović, Najda Rudman, Tomislav Bulum, Martina Tomić, Branimir Plavša, Sandra Vučković Rebrina, et al. "N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset." Clinica Chimica Acta 543 (2023). https://doi.org/10.1016/j.cca.2023.117298

Nemčić, M., et al. (2023) 'N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset', Clinica Chimica Acta, 543. doi: 10.1016/j.cca.2023.117298

Nemčić M, Tijardović M, Rudman N, Bulum T, Tomić M, Plavša B, and sur.. N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset. Clinica Chimica Acta [Internet]. 2023 March 15 [cited 2024 December 23];543. doi: 10.1016/j.cca.2023.117298

M. Nemčić, et al., "N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset", Clinica Chimica Acta, vol. 543, March 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:217826. [Accessed: 23 December 2024]

Metadata
Title (english)N-glycosylation of serum proteins in adult type 1 diabetes mellitus exposes further changes compared to children at the disease onset
AuthorMatej Nemčić
AuthorMarko Tijardović
AuthorNajda Rudman
AuthorTomislav Bulum
AuthorMartina Tomić
AuthorBranimir Plavša
AuthorSandra Vučković Rebrina
AuthorMarijana Vučić Lovrenčić
AuthorLea Duvnjak
AuthorGrant Morahan
AuthorOlga Gornik
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Objective: Previously we have shown that plasma protein N-glycosylation is changed in children at the onset of type 1 diabetes. In this study, we aim to identify N-glycan changes in adults with T1DM, compare them to those in children, and investigate their associations with disease duration, complications, glycaemic status, and smoking. Methods: Serum protein N-glycans from 200 adults with type 1 diabetes and 298 healthy controls were analysed using ultra-high performance liquid chromatography and divided into 39 directly measured glycan groups from which 16 derived traits were calculated. Results: Compared to healthy controls, subjects with type 1 diabetes showed differences in 19 glycan groups and a decrease in monogalactosylated, an increase in digalactosylated, monosialylated, and antennary fucosylated derived traits, from which changes in monogalactosylation and seven directly measured traits overlapped with previously reported in children. Changes in four directly measured and two derived traits previously seen in children were not detected in adults. HbA1c was positively associated with sialylated and highly branched structures, whereas N-glycome was not influenced by disease duration or diabetic complications. Conclusions: Our results suggest potential N-glycome involvement in different stages of type 1 diabetes, including processes underlying its development, the disease itself, as well as those occurring after disease establishment.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleClinica Chimica Acta
Numberingvol. 543, 117298
p-ISSN0009-8981
DOIhttps://doi.org/10.1016/j.cca.2023.117298
URN:NBNurn:nbn:hr:105:217826
Publication2023-03-15
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0009898123001006
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2024-01-11 10:00:04