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Scientific paper - Original scientific paper
The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia
Biomolecules, 13 (2023), 2; 297. https://doi.org/10.3390/biom13020297
Šagud, Marina; Madžarac, Zoran; Nedić Erjavec, Gordana; Šimunović Filipčić, Ivona; Mikulić, Filip Luka; Rogić, Dunja; Bradaš, Zoran; Bajs Janović, Maja; Pivac, Nela

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Šagud, M., Madžarac, Z., Nedić Erjavec, G., Šimunović Filipčić, I., Mikulić, F. L., Rogić, D. ... Pivac, N. (2023). The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia. Biomolecules, 13. (2). doi: 10.3390/biom13020297

Šagud, Marina, et al. "The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia." Biomolecules, vol. 13, no. 2, 2023. https://doi.org/10.3390/biom13020297

Šagud, Marina, Zoran Madžarac, Gordana Nedić Erjavec, Ivona Šimunović Filipčić, Filip Luka Mikulić, Dunja Rogić, Zoran Bradaš, Maja Bajs Janović and Nela Pivac. "The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia." Biomolecules 13, no. 2 (2023). https://doi.org/10.3390/biom13020297

Šagud, M., et al. (2023) 'The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia', Biomolecules, 13(2). doi: 10.3390/biom13020297

Šagud M, Madžarac Z, Nedić Erjavec G, Šimunović Filipčić I, Mikulić FL, Rogić D, and sur.. The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia. Biomolecules [Internet]. 2023 February 04 [cited 2025 January 18];13(2). doi: 10.3390/biom13020297

M. Šagud, et al., "The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia", Biomolecules, vol. 13, no. 2, February 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:162116. [Accessed: 18 January 2025]

Metadata
Title (english)The Associations of Neutrophil–Lymphocyte, Platelet–Lymphocyte, Monocyte–Lymphocyte Ratios and Immune-Inflammation Index with Negative Symptoms in Patients with Schizophrenia
AuthorMarina Šagud
AuthorZoran Madžarac
AuthorGordana Nedić Erjavec
AuthorIvona Šimunović Filipčić
AuthorFilip Luka Mikulić
AuthorDunja Rogić
AuthorZoran Bradaš
AuthorMaja Bajs Janović
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Psychiatry and Psychological Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Psychiatry
Abstract (english)
Neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), monocyte–lymphocyte ratio (MLR) and systemic immune-inflammation index (SII index) are increasingly used as indicators of inflammation in different conditions, including schizophrenia. However, their relationship with negative symptoms, including anhedonia, is largely unknown. Included were 200 patients with schizophrenia and 134 healthy controls (HC), assessed for physical anhedonia (PA), using the Revised Physical Anhedonia Scale (RPAS), and social anhedonia (SA) by the Revised Social Anhedonia Scale (RSAS). Patients were rated by the Positive and Negative Syndrome Scale (PANSS), the Clinical Assessment Interview for Negative Symptoms (CAINS) and the Brief Negative Symptom Scale (BNSS). Most of the negative symptoms were in a weak to moderate positive correlations with blood cell inflammatory ratios, namely, between NLR and MLR with PANSS negative scale, CAINS, and BNSS, and in male patients, between PLR and PANSS negative scale and CAINS. Fewer correlations were detected in females, but also in a positive direction. An exception was SA, given the negative correlation between its severity and the SII index in females, and its presence and higher PLR in males. While different negative symptoms were associated with subclinical inflammation, the relationship between SA and lower inflammatory markers deserves further exploration.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomolecules
Numberingvol. 13, no. 2, 297
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom13020297
URN:NBNurn:nbn:hr:105:162116
Publication2023-02-04
ProjectNumber: 098-0982522-2455
Title (croatian): Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja
Title (english): Molecular basis and treatment of psychiatric and stress related disorders
Leader: Nela Pivac
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttps://www.mdpi.com/2218-273X/13/2/297
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-01-15 08:53:16