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Scientific paper - Original scientific paper
Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients
International Journal of Molecular Sciences, 24 (2023), 3; 2073. https://doi.org/10.3390/ijms24032073
Klobučar, Iva; Stadler, Julia T.; Klobučar, Lucija; Lechleitner, Margarete; Trbušić, Matias; Pregartner, Gudrun; Berghold, Andrea; Habisch, Hansjörg; Madl, Tobias; Marsche, Gunther; Frank, Saša; Degoricija, Vesna

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Klobučar, I., Stadler, J. T., Klobučar, L., Lechleitner, M., Trbušić, M., Pregartner, G. ... Degoricija, V. (2023). Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients. International Journal of Molecular Sciences, 24. (3). doi: 10.3390/ijms24032073

Klobučar, Iva, et al. "Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients." International Journal of Molecular Sciences, vol. 24, no. 3, 2023. https://doi.org/10.3390/ijms24032073

Klobučar, Iva, Julia T. Stadler, Lucija Klobučar, Margarete Lechleitner, Matias Trbušić, Gudrun Pregartner, Andrea Berghold, et al. "Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients." International Journal of Molecular Sciences 24, no. 3 (2023). https://doi.org/10.3390/ijms24032073

Klobučar, I., et al. (2023) 'Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients', International Journal of Molecular Sciences, 24(3). doi: 10.3390/ijms24032073

Klobučar I, Stadler JT, Klobučar L, Lechleitner M, Trbušić M, Pregartner G, and sur.. Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients. International Journal of Molecular Sciences [Internet]. 2023 January 20 [cited 2024 December 27];24(3). doi: 10.3390/ijms24032073

I. Klobučar, et al., "Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients", International Journal of Molecular Sciences, vol. 24, no. 3, January 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:631645. [Accessed: 27 December 2024]

Metadata
Title (english)Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients
AuthorIva Klobučar
AuthorJulia T. Stadler
AuthorLucija Klobučar
AuthorMargarete Lechleitner
AuthorMatias Trbušić
AuthorGudrun Pregartner
AuthorAndrea Berghold
AuthorHansjörg Habisch
AuthorTobias Madl
AuthorGunther Marsche
AuthorSaša Frank
AuthorVesna Degoricija
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Metabolic syndrome (MS) is characterized by endothelial- and high-density lipoprotein (HDL) dysfunction and increased endothelial lipase (EL) serum levels. We examined the associations between EL serum levels, HDL (serum levels, lipid content, and function), and endothelial function in healthy volunteers (HV) and MS patients. Flow-mediated dilation (FMD), nitroglycerin-mediated dilation (NMD), serum levels of HDL subclasses (measured by nuclear magnetic resonance (NMR) spectroscopy), and EL serum levels differed significantly between HV and MS patients. The serum levels of triglycerides in large HDL particles were significantly positively correlated with FMD and NMD in HV, but not in MS patients. Cholesterol (C) and phospholipid (PL) contents of large HDL particles, calculated as HDL1-C/HDL1-apoA-I and HDL1-PL/HDL1-apoA-I, respectively, were significantly negatively correlated with FMD in HV, but not in MS patients. Cholesterol efflux capacity and arylesterase activity of HDL, as well as EL, were correlated with neither FMD nor NMD. EL was significantly negatively correlated with HDL-PL/HDL-apoA-I in HV, but not in MS patients, and with serum levels of small dense HDL containing apolipoprotein A-II in MS patients, but not in HV. We conclude that MS modulates the association between HDL and endothelial function, as well as between EL and HDL. HDL cholesterol efflux capacity and arylesterase activity, as well as EL serum levels, are not associated with endothelial function in HV or MS patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 24, no. 3, 2073
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms24032073
URN:NBNurn:nbn:hr:105:631645
Publication2023-01-20
Document URLhttps://www.mdpi.com/1422-0067/24/3/2073
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-01-16 09:02:40