prikaz prve stranice dokumenta A Novel Three-Dimensional Approach Towards Evaluating Endomyocardial Biopsies for Follow-Up After Heart Transplantation: X-Ray Phase Contrast Imaging and Its Agreement With Classical Histopathology
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Scientific paper - Original scientific paper
A Novel Three-Dimensional Approach Towards Evaluating Endomyocardial Biopsies for Follow-Up After Heart Transplantation: X-Ray Phase Contrast Imaging and Its Agreement With Classical Histopathology
Transplant International, 36 (2023); 11046. https://doi.org/10.3389/ti.2023.11046
Planinc, Ivo; Ilić, Ivana; Dejea, Hector; Garcia-Canadilla, Patricia; Gašparović, Hrvoje; Jurin, Hrvoje; Miličić, Davor; Skorić, Boško; Stampanoni, Marco; Bijnens, Bart; Bonnin, Anne; Čikes, Maja

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Planinc, I., Ilić, I., Dejea, H., Garcia Canadilla, P., Gašparović, H., Jurin, H. ... Čikes, M. (2023). A Novel Three-Dimensional Approach Towards Evaluating Endomyocardial Biopsies for Follow-Up After Heart Transplantation: X-Ray Phase Contrast Imaging and Its Agreement With Classical Histopathology. Transplant International, 36.. doi: 10.3389/ti.2023.11046

Planinc, Ivo, et al. "A Novel Three-Dimensional Approach Towards Evaluating Endomyocardial Biopsies for Follow-Up After Heart Transplantation: X-Ray Phase Contrast Imaging and Its Agreement With Classical Histopathology." Transplant International, vol. 36, 2023. https://doi.org/10.3389/ti.2023.11046

Planinc, Ivo, Ivana Ilić, Hector Dejea, Patricia Garcia Canadilla, Hrvoje Gašparović, Hrvoje Jurin, Davor Miličić, et al. "A Novel Three-Dimensional Approach Towards Evaluating Endomyocardial Biopsies for Follow-Up After Heart Transplantation: X-Ray Phase Contrast Imaging and Its Agreement With Classical Histopathology." Transplant International 36 (2023). https://doi.org/10.3389/ti.2023.11046

Planinc, I., et al. (2023) 'A Novel Three-Dimensional Approach Towards Evaluating Endomyocardial Biopsies for Follow-Up After Heart Transplantation: X-Ray Phase Contrast Imaging and Its Agreement With Classical Histopathology', Transplant International, 36. doi: 10.3389/ti.2023.11046

Planinc I, Ilić I, Dejea H, Garcia Canadilla P, Gašparović H, Jurin H, and sur.. A Novel Three-Dimensional Approach Towards Evaluating Endomyocardial Biopsies for Follow-Up After Heart Transplantation: X-Ray Phase Contrast Imaging and Its Agreement With Classical Histopathology. Transplant International [Internet]. 2023 January 24 [cited 2024 April 29];36. doi: 10.3389/ti.2023.11046

I. Planinc, et al., "A Novel Three-Dimensional Approach Towards Evaluating Endomyocardial Biopsies for Follow-Up After Heart Transplantation: X-Ray Phase Contrast Imaging and Its Agreement With Classical Histopathology", Transplant International, vol. 36, January 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:874985. [Accessed: 29 April 2024]

Metadata
Title (english)A Novel Three-Dimensional Approach Towards Evaluating Endomyocardial Biopsies for Follow-Up After Heart Transplantation: X-Ray Phase Contrast Imaging and Its Agreement With Classical Histopathology
AuthorIvo Planinc
AuthorIvana Ilić
AuthorHector Dejea
AuthorPatricia Garcia-Canadilla
AuthorHrvoje Gašparović
AuthorHrvoje Jurin
AuthorDavor Miličić
AuthorBoško Skorić
AuthorMarco Stampanoni
AuthorBart Bijnens
AuthorAnne Bonnin
AuthorMaja Čikes
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Endomyocardial biopsies are the gold standard for surveillance of graft rejection following heart transplantation, and are assessed by classical histopathology using a limited number of previously stained slices from several biopsies. Synchrotron propagation-based X-ray phase contrast imaging is a non-destructive method to image biological samples without tissue preparation, enabling virtual 2D and 3D histopathology. We aimed to show the feasibility of this method to assess acute cellular rejection and its agreement to classical histopathology. Right ventricular biopsies were sampled from 23 heart transplantation recipients (20 males, mean age 54±14 years) as part of standard follow-up. The clinical diagnosis of potential rejection was made using classical histopathology. One additional study sample was harvested and imaged by X-ray phase contrast imaging, producing 3D datasets with 0.65 μm pixel size, and up to 4,320 images per sample. An experienced pathologist graded both histopathological and X-ray phase contrast images in a blinded fashion. The agreement between methods was assessed by weighted kappa, showing substantial agreement (kappa up to 0.80, p < 0.01) between X-ray phase contrast imaging and classical histopathology. X-ray phase contrast imaging does not require tissue processing, allows thorough analysis of a full myocardial sample and allows identification of acute cellular rejection.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleTransplant International
Numberingvol. 36, 11046
e-ISSN1432-2277
DOIhttps://doi.org/10.3389/ti.2023.11046
URN:NBNurn:nbn:hr:105:874985
Publication2023-01-24
ProjectNumber: IP-2020-02-5572
Title (croatian): Nova paradigma utvrđivanja odbacivanja presatka srca: dijagnostika fazno-kontrastnim oslikavanjem X-zrakama proizvedenim sinkrotronom
Title (english): New Paradigm in Graft Rejection Detection in Heart Transplantation Recipients: Diagnostic Utility of Synchrotron X-ray Phase Contrast Imaging
Acronym: GRAFT-XPCI
Leader: Maja Čikeš
Jurisdiction: Croatia
Funding stream: Nema
Document URLhttps://www.frontierspartnerships.org/articles/10.3389/ti.2023.11046/full
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-01-16 09:12:29