prikaz prve stranice dokumenta cfDNA methylation in liquid biopsies as potential testicular seminoma biomarker
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Scientific paper - Original scientific paper
cfDNA methylation in liquid biopsies as potential testicular seminoma biomarker
Epigenomics, 14 (2022), 23; 1493-1507. https://doi.org/10.2217/epi-2022-0331
Raos, Dora; Oršolić, Davor; Mašić, Silvija; Tomić, Miroslav; Krasić, Jure; Tomašković, Igor; Nikolac Gabaj, Nora; Gelo, Nina; Kaštelan, Željko; Kuliš, Tomislav; Katušić Bojanac, Ana; Barešić, Anja; Ulamec, Monika; Ježek, Davor; Sinčić, Nino More authors...

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Raos, D., Oršolić, D., Mašić, S., Tomić, M., Krasić, J., Tomašković, I. ... Sinčić, N. (2022). cfDNA methylation in liquid biopsies as potential testicular seminoma biomarker. Epigenomics, 14. (23), 1493-1507. doi: 10.2217/epi-2022-0331

Raos, Dora, et al. "cfDNA methylation in liquid biopsies as potential testicular seminoma biomarker." Epigenomics, vol. 14, no. 23, 2022, pp. 1493-1507. https://doi.org/10.2217/epi-2022-0331

Raos, Dora, Davor Oršolić, Silvija Mašić, Miroslav Tomić, Jure Krasić, Igor Tomašković, Nora Nikolac Gabaj, et al. "cfDNA methylation in liquid biopsies as potential testicular seminoma biomarker." Epigenomics 14, no. 23 (2022): 1493-1507. https://doi.org/10.2217/epi-2022-0331

Raos, D., et al. (2022) 'cfDNA methylation in liquid biopsies as potential testicular seminoma biomarker', Epigenomics, 14(23), pp. 1493-1507. doi: 10.2217/epi-2022-0331

Raos D, Oršolić D, Mašić S, Tomić M, Krasić J, Tomašković I, and sur.. cfDNA methylation in liquid biopsies as potential testicular seminoma biomarker. Epigenomics [Internet]. 2022 December [cited 2024 November 22];14(23):1493-1507. doi: 10.2217/epi-2022-0331

D. Raos, et al., "cfDNA methylation in liquid biopsies as potential testicular seminoma biomarker", Epigenomics, vol. 14, no. 23, pp. 1493-1507, December 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:137437. [Accessed: 22 November 2024]

Metadata
Title (english)cfDNA methylation in liquid biopsies as potential testicular seminoma biomarker
AuthorDora Raos
AuthorDavor Oršolić
AuthorSilvija Mašić
AuthorMiroslav Tomić
AuthorJure Krasić
AuthorIgor Tomašković
AuthorNora Nikolac Gabaj
AuthorNina Gelo
AuthorŽeljko Kaštelan
AuthorTomislav Kuliš
AuthorAna Katušić Bojanac
AuthorAnja Barešić
AuthorMonika Ulamec
AuthorDavor Ježek
AuthorNino Sinčić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pathology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Cytology, Histology and Embryology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract (english)
Background: Seminoma is a testicular tumor type, routinely diagnosed after orchidectomy. As cfDNA represents a source of minimally invasive seminoma patient management, this study aimed to investigate whether cfDNA methylation of six genes from liquid biopsies, have potential as novel seminoma biomarkers. Materials & methods: cfDNA methylation from liquid biopsies was assessed by pyrosequencing and compared with healthy volunteers' samples. Results: Detailed analysis revealed specific CpGs as possible seminoma biomarkers, but receiver operating characteristic curve analysis showed modest diagnostic performance. In an analysis of panels of statistically significant CpGs, two DNA methylation panels emerged as potential seminoma screening panels, one in blood CpG8/CpG9/CpG10 (KITLG) and the other in seminal plasma CpG1(MAGEC2)/CpG1(OCT3/4). Conclusion: The presented data promote the development of liquid biopsy epigenetic biomarkers in the screening of seminoma patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleEpigenomics
Numberingvol. 14, no. 23, pp. 1493-1507
p-ISSN1750-1911
e-ISSN1750-192X
DOIhttps://doi.org/10.2217/epi-2022-0331
URN:NBNurn:nbn:hr:105:137437
Publication2022-12
ProjectNumber: KK.01.1.1.01.0008
Title (english): Reproduktivna i regenerativna medicina - istraživanje novih platformi i potencijala
Leader: Ana Katušić Bojanac
Jurisdiction: Croatia
ProjectNumber: IP-2016-06-3692
Title (croatian): Epigenetički biomarkeri u krvi i ejakulatu bolesnika sa seminomom testisa
Acronym: epiSem
Leader: Davor Ježek
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://www.futuremedicine.com/doi/10.2217/epi-2022-0331
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2024-01-22 08:40:49