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professional thesis
Ekvivalent: Angiotenzin-konvertirajući enzim 2 (ACE2) kao potencijalni dijagnostički i prognostički biomarker za kronične upalne bolesti pluća
Zagreb: University of Zagreb, School of Medicine, 2023. urn:nbn:hr:105:798355
Marčetić, Dejan
University of Zagreb
School of Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Marčetić, D. (2023). Ekvivalent: Angiotenzin-konvertirajući enzim 2 (ACE2) kao potencijalni dijagnostički i prognostički biomarker za kronične upalne bolesti pluća (Professional thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:798355

Marčetić, Dejan. "Ekvivalent: Angiotenzin-konvertirajući enzim 2 (ACE2) kao potencijalni dijagnostički i prognostički biomarker za kronične upalne bolesti pluća." Professional thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:798355

Marčetić, Dejan. "Ekvivalent: Angiotenzin-konvertirajući enzim 2 (ACE2) kao potencijalni dijagnostički i prognostički biomarker za kronične upalne bolesti pluća." Professional thesis, University of Zagreb, School of Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:105:798355

Marčetić, D. (2023). 'Ekvivalent: Angiotenzin-konvertirajući enzim 2 (ACE2) kao potencijalni dijagnostički i prognostički biomarker za kronične upalne bolesti pluća', Professional thesis, University of Zagreb, School of Medicine, accessed 05 May 2024, https://urn.nsk.hr/urn:nbn:hr:105:798355

Marčetić D. Ekvivalent: Angiotenzin-konvertirajući enzim 2 (ACE2) kao potencijalni dijagnostički i prognostički biomarker za kronične upalne bolesti pluća [Professional thesis]. Zagreb: University of Zagreb, School of Medicine; 2023 [cited 2024 May 05] Available at: https://urn.nsk.hr/urn:nbn:hr:105:798355

D. Marčetić, "Ekvivalent: Angiotenzin-konvertirajući enzim 2 (ACE2) kao potencijalni dijagnostički i prognostički biomarker za kronične upalne bolesti pluća", Professional thesis, University of Zagreb, School of Medicine, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:105:798355

Metadata
TitleEkvivalent: Angiotenzin-konvertirajući enzim 2 (ACE2) kao potencijalni dijagnostički i prognostički biomarker za kronične upalne bolesti pluća
Title (english)Angiotensin-Converting Enzyme 2 (ACE2) as a Potential Diagnostic and Prognostic Biomarker for Chronic Inflammatory Lung Diseases
AuthorDejan Marčetić
MentorMiroslav Samaržija (mentor)
GranterUniversity of Zagreb
School of Medicine
Zagreb
Defense date and country2023-06-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Abstract: Chronic inflammatory lung diseases are characterized by uncontrolled immune response in the airways as their main pathophysiological manifestation. The lack of specific diagnostic and therapeutic biomarkers for many pulmonary diseases represents a major challenge for pulmonologists. The majority of the currently approved therapeutic approaches are focused on achieving disease remission, although there is no guarantee of complete recovery. It is known that angiotensin-converting enzyme 2 (ACE2), an important counter-regulatory component of the renin–angiotensin–aldosteronesystem (RAAS), is expressed in the airways. It has been shown that ACE2 plays a role in systemic regulation of the cardiovascular and renal systems, lungs and liver by acting on blood pressure, electrolyte balance control mechanisms and inflammation. Its protective role in the lungs has also been presented, but the exact pathophysiological mechanism of action is still elusive. The aim of this study is to review and discuss recent findings about ACE2, including its potential role in the pathophysiology of chronic inflammatory lung diseases:, i.e., chronic obstructive pulmonary disease, asthma, and pulmonary hypertension. Additionally, in the light of the coronavirus 2019 disease (COVID-19), we will discuss the role of ACE2 in the pathophysiology of this disease, mainly represented by different grades of pulmonary problems. We believe that these insights will open up new perspectives for the future use of ACE2 as a potential biomarker for early diagnosis and monitoring of chronic inflammatory lung diseases.
Keywords
Languageenglish
URN:NBNurn:nbn:hr:105:798355
Study programmeTitle: Pulmonology
Study programme type: university
Study level: postgraduate specialist
Academic / professional title: sveučilišni/a magistar/magistra pulmologije (sveučilišni/a magistar/magistra pulmologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-01-26 12:26:24