prikaz prve stranice dokumenta Association between Serum Free Fatty Acids and Clinical and Laboratory Parameters in Acute Heart Failure Patients
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Scientific paper - Original scientific paper
Association between Serum Free Fatty Acids and Clinical and Laboratory Parameters in Acute Heart Failure Patients
Biomedicines, 11 (2023), 12; 3197. https://doi.org/10.3390/biomedicines11123197
Klobučar, Iva; Hinteregger, Helga; Lechleitner, Margarete; Trbušić, Matias; Pregartner, Gudrun; Berghold, Andrea; Sattler, Wolfgang; Frank, Saša; Degoricija, Vesna

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Klobučar, I., Hinteregger, H., Lechleitner, M., Trbušić, M., Pregartner, G., Berghold, A. ... Degoricija, V. (2023). Association between Serum Free Fatty Acids and Clinical and Laboratory Parameters in Acute Heart Failure Patients. Biomedicines, 11. (12). doi: 10.3390/biomedicines11123197

Klobučar, Iva, et al. "Association between Serum Free Fatty Acids and Clinical and Laboratory Parameters in Acute Heart Failure Patients." Biomedicines, vol. 11, no. 12, 2023. https://doi.org/10.3390/biomedicines11123197

Klobučar, Iva, Helga Hinteregger, Margarete Lechleitner, Matias Trbušić, Gudrun Pregartner, Andrea Berghold, Wolfgang Sattler, Saša Frank and Vesna Degoricija. "Association between Serum Free Fatty Acids and Clinical and Laboratory Parameters in Acute Heart Failure Patients." Biomedicines 11, no. 12 (2023). https://doi.org/10.3390/biomedicines11123197

Klobučar, I., et al. (2023) 'Association between Serum Free Fatty Acids and Clinical and Laboratory Parameters in Acute Heart Failure Patients', Biomedicines, 11(12). doi: 10.3390/biomedicines11123197

Klobučar I, Hinteregger H, Lechleitner M, Trbušić M, Pregartner G, Berghold A, and sur.. Association between Serum Free Fatty Acids and Clinical and Laboratory Parameters in Acute Heart Failure Patients. Biomedicines [Internet]. 2023 December 01 [cited 2024 November 26];11(12). doi: 10.3390/biomedicines11123197

I. Klobučar, et al., "Association between Serum Free Fatty Acids and Clinical and Laboratory Parameters in Acute Heart Failure Patients", Biomedicines, vol. 11, no. 12, December 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:499956. [Accessed: 26 November 2024]

Metadata
Title (english)Association between Serum Free Fatty Acids and Clinical and Laboratory Parameters in Acute Heart Failure Patients
AuthorIva Klobučar
AuthorHelga Hinteregger
AuthorMargarete Lechleitner
AuthorMatias Trbušić
AuthorGudrun Pregartner
AuthorAndrea Berghold
AuthorWolfgang Sattler
AuthorSaša Frank
AuthorVesna Degoricija
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Very little is known about the association between individual serum free fatty acids (FFAs) and clinical and laboratory parameters (indicators of heart failure severity) in acute heart failure (AHF) patients. Here, the baseline serum levels of FFAs, 16:0 (palmitic acid), 16:1 (palmitoleic acid), 18:0 (stearic acid), 18:1 (oleic acid), 18:2 (linoleic acid), 18:3 (alpha-linolenic acid or gamma-linolenic acid), 20:4 (arachidonic acid), 20:5 (eicosapentaenoic acid), and 22:6 (docosahexaenoic acid), were determined in 304 AHF patients (94.7% belonged to New York Heart Association functional class IV) using gas chromatography. Spearman correlation coefficients were used to examine the associations between the individual and total (the sum of all FFAs) FFAs and clinical and laboratory parameters. After applying a Bonferroni correction to correct for multiple testing, the total FFAs, as well as the individual FFAs (except FFAs 18:0, 20:5, and 22:6), were found to be significantly positively correlated with serum albumin. Only a few additional associations were found: FFA 16:0 was significantly negatively correlated with systolic pulmonary artery pressure, FFA 18:3 was significantly negatively correlated with C-reactive protein and body mass index, and FFA 20:4 was significantly negatively correlated with blood urea nitrogen. Based on our results, we conclude that in patients with severe AHF, individual and total serum FFAs are slightly associated with established laboratory and clinical parameters, which are indicators of heart failure severity.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 11, no. 12, 3197
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines11123197
URN:NBNurn:nbn:hr:105:499956
Publication2023-12-01
Document URLhttps://www.mdpi.com/2227-9059/11/12/3197
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-03-04 09:53:03