prikaz prve stranice dokumenta D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?
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Scientific paper - Original scientific paper
D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?
BioEssays, 46 (2023), 2; e2300061. https://doi.org/10.1002/bies.202300061
Homolak, Jan; Babić Perhoč, Ana; Virag, Davor; Knezović, Ana; Osmanović Barilar, Jelena; Šalković‐Petrišić, Melita

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Homolak, J., Babić Perhoč, A., Virag, D., Knezović, A., Osmanović Barilar, J. & Šalković‐Petrišić, M. (2023). D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?. BioEssays, 46. (2). doi: 10.1002/bies.202300061

Homolak, Jan, et al. "D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?." BioEssays, vol. 46, no. 2, 2023. https://doi.org/10.1002/bies.202300061

Homolak, Jan, Ana Babić Perhoč, Davor Virag, Ana Knezović, Jelena Osmanović Barilar and Melita Šalković‐Petrišić. "D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?." BioEssays 46, no. 2 (2023). https://doi.org/10.1002/bies.202300061

Homolak, J., et al. (2023) 'D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?', BioEssays, 46(2). doi: 10.1002/bies.202300061

Homolak J, Babić Perhoč A, Virag D, Knezović A, Osmanović Barilar J, Šalković‐Petrišić M. D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?. BioEssays [Internet]. 2023 December 06 [cited 2024 April 29];46(2). doi: 10.1002/bies.202300061

J. Homolak, A. Babić Perhoč, D. Virag, A. Knezović, J. Osmanović Barilar and M. Šalković‐Petrišić, "D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?", BioEssays, vol. 46, no. 2, December 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:763837. [Accessed: 29 April 2024]

Metadata
Title (english)D‐galactose might mediate some of the skeletal muscle hypertrophy‐promoting effects of milk—A nutrient to consider for sarcopenia?
AuthorJan Homolak
AuthorAna Babić Perhoč
AuthorDavor Virag
AuthorAna Knezović
AuthorJelena Osmanović Barilar
AuthorMelita Šalković‐Petrišić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Sarcopenia is a process of progressive aging‐associated loss of skeletal muscle mass (SMM) recognized as a serious global health issue contributing to frailty and increased all‐cause mortality. Exercise and nutritional interventions (particularly intake of dairy products and milk) demonstrate good efficacy, safety, and broad applicability. Here, we propose that at least some of the well‐documented favorable effects of milk and milk‐derived protein supplements on SMM might be mediated by D‐galactose, a monosaccharide present in large quantities in milk in the form of disaccharide lactose (milk sugar). We suggest that ingestion of dairy products results in exposure to D‐galactose in concentrations metabolized primarily via the Leloir pathway with the potential to (i) promote anabolic signaling via maintenance of growth factor (e.g., insulin‐like growth factor 1 [IGF‐1]) receptor mature glycosylation patterns; and (ii) provide extracellular (liver glycogen) and intracellular substrates for short (muscle glycolysis) and long‐term (muscle glycogen, intramyocellular lipids) energy availability. Additionally, D‐galactose might optimize the metabolic function of skeletal muscles by increasing mitochondrial content and stimulating glucose and fatty acid utilization. The proposed potential of D‐galactose to promote the accretion of SMM is discussed in the context of its therapeutic potential in sarcopenia.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBioEssays
Numberingvol. 46, no. 2, e2300061
p-ISSN0265-9247
e-ISSN1521-1878
DOIhttps://doi.org/10.1002/bies.202300061
URN:NBNurn:nbn:hr:105:763837
Publication2023-12-06
ProjectNumber: IP-2018-01-8938
Title (croatian): Mehanizmi nutrijentom posredovanih učinaka endogenog glukagonu sličnog peptida-1 na kognitivne i metaboličke poremećaje u eksperimentalnim modelima neurodegenerativnih bolesti
Acronym: NutrientGLP-1
Leader: Melita Šalković-Petrišić
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: KK.01.1.1.01.0007
Title (english): Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi
Leader: Ivica Kostović
Jurisdiction: eu
Document URLhttps://onlinelibrary.wiley.com/doi/10.1002/bies.202300061
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2024-03-07 11:57:50