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Scientific paper - Original scientific paper
Bone morphogenetic protein (BMP)1-3 enhances bone repair
Biochemical and Biophysical Research Communications, 408 (2011), 1; 25-31. https://doi.org/10.1016/j.bbrc.2011.03.109
Grgurević, Lovorka; Maček, Boris; Merčep, Mladen; Jelić, Mislav; Smoljanović, Tomislav; Erjavec, Igor; Dumić-Čule, Ivo; Prgomet, Stefan; Đurđević, Dragan; Vnuk, Dražen; Lipar, Marija; Stejskal, Marko; Kufner, Vera; Brkljačić, Jelena; Matičić, Dražen; Vukičević, Slobodan More authors...

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Grgurević, L., Maček, B., Merčep, M., Jelić, M., Smoljanović, T., Erjavec, I. ... Vukičević, S. (2011). Bone morphogenetic protein (BMP)1-3 enhances bone repair. Biochemical and Biophysical Research Communications, 408. (1), 25-31. doi: 10.1016/j.bbrc.2011.03.109

Grgurević, Lovorka, et al. "Bone morphogenetic protein (BMP)1-3 enhances bone repair." Biochemical and Biophysical Research Communications, vol. 408, no. 1, 2011, pp. 25-31. https://doi.org/10.1016/j.bbrc.2011.03.109

Grgurević, Lovorka, Boris Maček, Mladen Merčep, Mislav Jelić, Tomislav Smoljanović, Igor Erjavec, Ivo Dumić Čule, et al. "Bone morphogenetic protein (BMP)1-3 enhances bone repair." Biochemical and Biophysical Research Communications 408, no. 1 (2011): 25-31. https://doi.org/10.1016/j.bbrc.2011.03.109

Grgurević, L., et al. (2011) 'Bone morphogenetic protein (BMP)1-3 enhances bone repair', Biochemical and Biophysical Research Communications, 408(1), pp. 25-31. doi: 10.1016/j.bbrc.2011.03.109

Grgurević L, Maček B, Merčep M, Jelić M, Smoljanović T, Erjavec I, and sur.. Bone morphogenetic protein (BMP)1-3 enhances bone repair. Biochemical and Biophysical Research Communications [Internet]. 2011 April 29 [cited 2024 November 29];408(1):25-31. doi: 10.1016/j.bbrc.2011.03.109

L. Grgurević, et al., "Bone morphogenetic protein (BMP)1-3 enhances bone repair", Biochemical and Biophysical Research Communications, vol. 408, no. 1, pp. 25-31, April 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:755290. [Accessed: 29 November 2024]

Metadata
Title (english)Bone morphogenetic protein (BMP)1-3 enhances bone repair
AuthorLovorka Grgurević
AuthorBoris Maček
AuthorMladen Merčep
AuthorMislav Jelić
AuthorTomislav Smoljanović
AuthorIgor Erjavec
AuthorIvo Dumić-Čule
AuthorStefan Prgomet
AuthorDragan Đurđević
AuthorDražen Vnuk
AuthorMarija Lipar
AuthorMarko Stejskal
AuthorVera Kufner
AuthorJelena Brkljačić
AuthorDražen Matičić
AuthorSlobodan Vukičević
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Members of the astacin family of metalloproteinases such as human bone morphogenetic protein 1 (BMP-1) regulate morphogenesis by processing precursors to mature functional extracellular matrix (ECM) proteins and several growth factors including TGFβ, BMP2, BMP4 and GFD8. We have recently discovered that BMP1-3 isoform of the Bmp-1 gene circulates in the human plasma and is significantly increased in patients with acute bone fracture. We hypothesized that circulating BMP1-3 might have an important role in bone repair and serve as a novel bone biomarker. When administered systemically to rats with a long bone fracture and locally to rabbits with a critical size defect of the ulna, recombinant human BMP1-3 enhanced bone healing. In contrast, neutralization of the endogenous BMP1-3 by a specific polyclonal antibody delayed the bone union. Invitro BMP1-3 increased the expression of collagen type I and osteocalcin in MC3T3-E(1) osteoblast like cells, and enhanced the formation of mineralized bone nodules from bone marrow mesenchymal stem cells. We suggest that BMP1-3 is a novel systemic regulator of bone repair.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleBiochemical and Biophysical Research Communications
Numberingvol. 408, no. 1, pp. 25-31
p-ISSN0006-291X
DOIhttps://doi.org/10.1016/j.bbrc.2011.03.109
URN:NBNurn:nbn:hr:105:755290
Publication2011-04-29
Document URLhttps://doi.org/10.1016/j.bbrc.2011.03.109
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:02:43