prikaz prve stranice dokumenta Concentration gradient of CXCL10 and CXCL11 between the cerebrospinal fluid and plasma in children with enteroviral aseptic meningitis
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Scientific paper - Original scientific paper
Concentration gradient of CXCL10 and CXCL11 between the cerebrospinal fluid and plasma in children with enteroviral aseptic meningitis
European Journal of Paediatric Neurology, 15 (2011), 6; 502-507. https://doi.org/10.1016/j.ejpn.2011.05.008
Čavčić, Anamarija; Tešović, Goran; Gorenec, Lana; Grgić, Ivana; Benić, Branka; Židovec Lepej, Snježana

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Čavčić, A., Tešović, G., Gorenec, L., Grgić, I., Benić, B. & Židovec Lepej, S. (2011). Concentration gradient of CXCL10 and CXCL11 between the cerebrospinal fluid and plasma in children with enteroviral aseptic meningitis. European Journal of Paediatric Neurology, 15. (6), 502-507. doi: 10.1016/j.ejpn.2011.05.008

Čavčić, Anamarija, et al. "Concentration gradient of CXCL10 and CXCL11 between the cerebrospinal fluid and plasma in children with enteroviral aseptic meningitis." European Journal of Paediatric Neurology, vol. 15, no. 6, 2011, pp. 502-507. https://doi.org/10.1016/j.ejpn.2011.05.008

Čavčić, Anamarija, Goran Tešović, Lana Gorenec, Ivana Grgić, Branka Benić and Snježana Židovec Lepej. "Concentration gradient of CXCL10 and CXCL11 between the cerebrospinal fluid and plasma in children with enteroviral aseptic meningitis." European Journal of Paediatric Neurology 15, no. 6 (2011): 502-507. https://doi.org/10.1016/j.ejpn.2011.05.008

Čavčić, A., et al. (2011) 'Concentration gradient of CXCL10 and CXCL11 between the cerebrospinal fluid and plasma in children with enteroviral aseptic meningitis', European Journal of Paediatric Neurology, 15(6), pp. 502-507. doi: 10.1016/j.ejpn.2011.05.008

Čavčić A, Tešović G, Gorenec L, Grgić I, Benić B, Židovec Lepej S. Concentration gradient of CXCL10 and CXCL11 between the cerebrospinal fluid and plasma in children with enteroviral aseptic meningitis. European Journal of Paediatric Neurology [Internet]. 2011 November [cited 2024 November 06];15(6):502-507. doi: 10.1016/j.ejpn.2011.05.008

A. Čavčić, G. Tešović, L. Gorenec, I. Grgić, B. Benić and S. Židovec Lepej, "Concentration gradient of CXCL10 and CXCL11 between the cerebrospinal fluid and plasma in children with enteroviral aseptic meningitis", European Journal of Paediatric Neurology, vol. 15, no. 6, pp. 502-507, November 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:679374. [Accessed: 06 November 2024]

Metadata
Title (english)Concentration gradient of CXCL10 and CXCL11 between the cerebrospinal fluid and plasma in children with enteroviral aseptic meningitis
AuthorAnamarija Čavčić
AuthorGoran Tešović
AuthorLana Gorenec
AuthorIvana Grgić
AuthorBranka Benić
AuthorSnježana Židovec Lepej
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: Lymphocyte migration from the blood into the CNS is mediated by chemokines and chemokine receptors. Chemokines CXCL10 and CXCL11 are important for the recruitment of CXCR3-expressing Th1 lymphocytes to the site of inflammation. ----- AIMS: To determine the concentrations of CXCL10 and CXCL11 in the CSF and plasma of children with enteroviral aseptic meningitis (EV AM) and controls and the contribution of these chemokines to the chemokine concentration gradient between the periphery and the CNS. ----- METHODS: The study included 26 pediatric patients with EV AM and 16 controls in whom CNS infection is excluded by negative CSF examination. Chemokines were quantified by using enzyme immunoassay. Etiological diagnosis of EV AM was based on the detection of enteroviral RNA in the CSF using real-time PCR. ----- RESULTS: CXCL10 (median 12 725 pg/ml) and CXCL11 (median 187 pg/ml) concentrations in CSF of patients with meningitis were significantly higher compared to plasma (median 173 pg/ml and median 110 pg/ml; p < 0.001, p = 0.026 respectively). CXCL10 concentrations in the CSF (median 198 pg/ml) and plasma of controls (median 124 pg/ml) were not significantly different (p = 0.642). CXCL11 concentrations in the CSF of controls (median 89 pg/ml) were significantly lower compared with plasma (median 139 pg/ml, p = 0.004). Chemokine concentration gradient was not influenced by pleocytosis, nor dependent on cytologic CSF formula or the presence of proteinorrachia. ----- CONCLUSION: CXCL10 and CXCL11 concentration gradient between the CSF and plasma in children with EV AM suggests an important role of these chemokines in the T-cells recruitment into the CNS and local immunoreaction.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleEuropean Journal of Paediatric Neurology
Numberingvol. 15, no. 6, pp. 502-507
p-ISSN1090-3798
DOIhttps://doi.org/10.1016/j.ejpn.2011.05.008
URN:NBNurn:nbn:hr:105:679374
Publication2011-11
Document URLhttps://doi.org/10.1016/j.ejpn.2011.05.008
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:04:11