prikaz prve stranice dokumenta Pilot study of the association between the HLA region and testicular carcinoma among Croatian patients
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Scientific paper - Original scientific paper
Pilot study of the association between the HLA region and testicular carcinoma among Croatian patients
Urologia Internationalis, 87 (2011), 3; 288-292. https://doi.org/10.1159/000329770
Gotovac, Kristina; Grubić, Zorana; Kaštelan, Željko; Štingl, Katarina; Kuliš, Tomislav; Krhen, Ivan; Hudolin, Tvrtko; Kaštelan, Maja; Žunec, Renata

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Gotovac, K., Grubić, Z., Kaštelan, Ž., Štingl, K., Kuliš, T., Krhen, I. ... Žunec, R. (2011). Pilot study of the association between the HLA region and testicular carcinoma among Croatian patients. Urologia Internationalis, 87. (3), 288-292. doi: 10.1159/000329770

Gotovac, Kristina, et al. "Pilot study of the association between the HLA region and testicular carcinoma among Croatian patients." Urologia Internationalis, vol. 87, no. 3, 2011, pp. 288-292. https://doi.org/10.1159/000329770

Gotovac, Kristina, Zorana Grubić, Željko Kaštelan, Katarina Štingl, Tomislav Kuliš, Ivan Krhen, Tvrtko Hudolin, Maja Kaštelan and Renata Žunec. "Pilot study of the association between the HLA region and testicular carcinoma among Croatian patients." Urologia Internationalis 87, no. 3 (2011): 288-292. https://doi.org/10.1159/000329770

Gotovac, K., et al. (2011) 'Pilot study of the association between the HLA region and testicular carcinoma among Croatian patients', Urologia Internationalis, 87(3), pp. 288-292. doi: 10.1159/000329770

Gotovac K, Grubić Z, Kaštelan Ž, Štingl K, Kuliš T, Krhen I, and sur.. Pilot study of the association between the HLA region and testicular carcinoma among Croatian patients. Urologia Internationalis [Internet]. 2011 [cited 2024 April 27];87(3):288-292. doi: 10.1159/000329770

K. Gotovac, et al., "Pilot study of the association between the HLA region and testicular carcinoma among Croatian patients", Urologia Internationalis, vol. 87, no. 3, pp. 288-292, 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:712654. [Accessed: 27 April 2024]

Metadata
Title (english)Pilot study of the association between the HLA region and testicular carcinoma among Croatian patients
AuthorKristina Gotovac
AuthorZorana Grubić
AuthorŽeljko Kaštelan
AuthorKatarina Štingl
AuthorTomislav Kuliš
AuthorIvan Krhen
AuthorTvrtko Hudolin
AuthorMaja Kaštelan
AuthorRenata Žunec
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
OBJECTIVES: To analyze the distribution of HLA alleles and HLA microsatellite alleles in Croatian patients with testicular carcinoma, compare it with that of healthy controls and investigate whether the polymorphism within the HLA region could be associated with the development of testicular cancer. ----- METHODS: Genomic DNA was isolated from the peripheral blood of 24 patients with testicular germ cell tumors (TGCT). Patients and controls were typed for HLA class I and class II polymorphism by the PCR-SSO method. Nine HLA microsatellites were analyzed by PCR and electrophoresis in an automated sequencer. ----- RESULTS: No significant deviation in the distribution of frequencies at HLA class I alleles was observed between patients and controls. Among HLA class II alleles, a statistically significant increase in the frequency of the HLA-DPB1*1701 allele was found among patients. The frequency of the HLA-DRB1*07-DQA1*0201-DQB1*0202 haplotype was increased in patients in comparison to the controls. Analysis of HLA microsatellites showed an increased frequency of D6S291-3 allele (p(corr) = 0.0455, OR = 3.05) among patients. ----- CONCLUSIONS: The observed association of the disease and the DPB1*1701 allele as well as with the D6S291-3 allele suggests that this part of the HLA region might be involved in the pathogenesis of TGCT. Our data provide a basis for further studies about the correlation between the HLA region and testicular cancer.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleUrologia Internationalis
Numberingvol. 87, no. 3, pp. 288-292
p-ISSN0042-1138
DOIhttps://doi.org/10.1159/000329770
URN:NBNurn:nbn:hr:105:712654
Publication2011
Document URLhttps://doi.org/10.1159/000329770
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:09:25