prikaz prve stranice dokumenta Bone morphogenetic protein-7 expression is down-regulated in human clear cell renal carcinoma
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Scientific paper - Original scientific paper
Bone morphogenetic protein-7 expression is down-regulated in human clear cell renal carcinoma
Journal of Nephrology, 24 (2011), 1; 91-97. https://doi.org/10.5301/JN.2010.2020
Bašić-Jukić, Nikolina; Hudolin, Tvrtko; Radić-Antolić, Margareta; Ćorić, Marijana; Zadro, Renata; Kaštelan, Željko; Pasini, Josip; Bandić-Pavlović, Daniela; Kes, Petar

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Bašić Jukić, N., Hudolin, T., Radić Antolić, M., Ćorić, M., Zadro, R., Kaštelan, Ž. ... Kes, P. (2011). Bone morphogenetic protein-7 expression is down-regulated in human clear cell renal carcinoma. Journal of Nephrology, 24. (1), 91-97. doi: 10.5301/JN.2010.2020

Bašić Jukić, Nikolina, et al. "Bone morphogenetic protein-7 expression is down-regulated in human clear cell renal carcinoma." Journal of Nephrology, vol. 24, no. 1, 2011, pp. 91-97. https://doi.org/10.5301/JN.2010.2020

Bašić Jukić, Nikolina, Tvrtko Hudolin, Margareta Radić Antolić, Marijana Ćorić, Renata Zadro, Željko Kaštelan, Josip Pasini, Daniela Bandić Pavlović and Petar Kes. "Bone morphogenetic protein-7 expression is down-regulated in human clear cell renal carcinoma." Journal of Nephrology 24, no. 1 (2011): 91-97. https://doi.org/10.5301/JN.2010.2020

Bašić Jukić, N., et al. (2011) 'Bone morphogenetic protein-7 expression is down-regulated in human clear cell renal carcinoma', Journal of Nephrology, 24(1), pp. 91-97. doi: 10.5301/JN.2010.2020

Bašić Jukić N, Hudolin T, Radić Antolić M, Ćorić M, Zadro R, Kaštelan Ž, and sur.. Bone morphogenetic protein-7 expression is down-regulated in human clear cell renal carcinoma. Journal of Nephrology [Internet]. 2011 January [cited 2024 April 28];24(1):91-97. doi: 10.5301/JN.2010.2020

N. Bašić Jukić, et al., "Bone morphogenetic protein-7 expression is down-regulated in human clear cell renal carcinoma", Journal of Nephrology, vol. 24, no. 1, pp. 91-97, January 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:797711. [Accessed: 28 April 2024]

Metadata
Title (english)Bone morphogenetic protein-7 expression is down-regulated in human clear cell renal carcinoma
AuthorNikolina Bašić-Jukić
AuthorTvrtko Hudolin
AuthorMargareta Radić-Antolić
AuthorMarijana Ćorić
AuthorRenata Zadro
AuthorŽeljko Kaštelan
AuthorJosip Pasini
AuthorDaniela Bandić-Pavlović
AuthorPetar Kes
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: Recent studies demonstrated that the expression pattern of bone morphogenetic protein-7 (BMP-7) is altered in different tumors. We determined expression of BMP-7 in human clear cell renal carcinoma (CCRC). ----- METHODS: Samples from cancer and corresponding healthy tissue were obtained from 20 patients who underwent nephrectomy for CCRC. Expression of BMP-7 mRNA was determined by reverse transcriptase polymerase chain reaction (RT-PCR), and protein expression was analyzed by immunohistochemistry. ----- RESULTS: RT-PCR showed strong down-regulation of BMP-7 mRNA in cancer tissue. Immunohistochemistry revealed expression of BMP-7 in normal renal tissue, with almost complete loss of BMP-7 expression in malignant cells of 6 patients (30%). After 3 years of follow-up, 5 out of 6 patients with high BMP-7 mRNA expression were alive and disease-free, compared with 9 out of 14 patients with low BMP-7 mRNA expression. ----- CONCLUSIONS: BMP-7 mRNA and protein expression were down-regulated in CCRC. Further prospective studies are needed to characterize the role of BMP-7 in human CCRC.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Nephrology
Numberingvol. 24, no. 1, pp. 91-97
p-ISSN1121-8428
DOIhttps://doi.org/10.5301/JN.2010.2020
URN:NBNurn:nbn:hr:105:797711
Publication2011-01
Document URLhttps://doi.org/10.5301/JN.2010.2020
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:09:52