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Professional paper - Review paper
Pharmaceutical principles of acid inhibitors: unmet needs
Digestive Diseases, 29 (2011), 5; 469-475. https://doi.org/10.1159/000331515
Krznarić, Željko; Ljubas Kelečić, Dina; Rustemović, Nadan; Vranešić Bender, Darija; Ostojić, Rajko; Markoš, Pave; Scarpignato, Carmelo

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Krznarić, Ž., Ljubas Kelečić, D., Rustemović, N., Vranešić Bender, D., Ostojić, R., Markoš, P. & Scarpignato, C. (2011). Pharmaceutical principles of acid inhibitors: unmet needs. Digestive Diseases, 29. (5), 469-475. doi: 10.1159/000331515

Krznarić, Željko, et al. "Pharmaceutical principles of acid inhibitors: unmet needs." Digestive Diseases, vol. 29, no. 5, 2011, pp. 469-475. https://doi.org/10.1159/000331515

Krznarić, Željko, Dina Ljubas Kelečić, Nadan Rustemović, Darija Vranešić Bender, Rajko Ostojić, Pave Markoš and Carmelo Scarpignato. "Pharmaceutical principles of acid inhibitors: unmet needs." Digestive Diseases 29, no. 5 (2011): 469-475. https://doi.org/10.1159/000331515

Krznarić, Ž., et al. (2011) 'Pharmaceutical principles of acid inhibitors: unmet needs', Digestive Diseases, 29(5), pp. 469-475. doi: 10.1159/000331515

Krznarić Ž, Ljubas Kelečić D, Rustemović N, Vranešić Bender D, Ostojić R, Markoš P, and sur.. Pharmaceutical principles of acid inhibitors: unmet needs. Digestive Diseases [Internet]. 2011 [cited 2024 October 15];29(5):469-475. doi: 10.1159/000331515

Ž. Krznarić, et al., "Pharmaceutical principles of acid inhibitors: unmet needs", Digestive Diseases, vol. 29, no. 5, pp. 469-475, 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:915594. [Accessed: 15 October 2024]

Metadata
Title (english)Pharmaceutical principles of acid inhibitors: unmet needs
AuthorŽeljko Krznarić
AuthorDina Ljubas Kelečić
AuthorNadan Rustemović
AuthorDarija Vranešić Bender
AuthorRajko Ostojić
AuthorPave Markoš
AuthorCarmelo Scarpignato
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Despite the well-established benefits of currently approved delayed-release proton pump inhibitors (PPIs) in the treatment of acid-related diseases, the unmet needs are still present and although often frustrating, they challenge clinicians. The unmet needs relate to the lack of complete control of acid secretion with oral PPI administration in the management of patients with gastroesophageal symptoms. These substantial groups of patients, who do not respond completely to standard doses of PPIs, are nonresponders, and their lack of response should be considered as PPI failure. Several mechanisms could explain PPI failure: differences in pharmacokinetics, PPI formulation, dosing time and diet, noncompliance, transient lower esophageal sphincter relaxations, esophageal hypersensitivity, and nocturnal acid breakthrough. To increase the quality of life of these patients and avoid multiple medical consultations and unnecessary investigations, we have to go one step forward and use combined therapy or look towards new treatments beyond acid suppression.
Keywords (english)
Languageenglish
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleDigestive Diseases
Numberingvol. 29, no. 5, pp. 469-475
p-ISSN0257-2753
DOIhttps://doi.org/10.1159/000331515
URN:NBNurn:nbn:hr:105:915594
Publication2011
Document URLhttps://doi.org/10.1159/000331515
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:12:41