prikaz prve stranice dokumenta Radiation therapy in treatment of fibrodysplasia ossificans progressiva: a case report and review of the literature
  Download
PDF 95.76 KB
Scientific paper - Case study
Radiation therapy in treatment of fibrodysplasia ossificans progressiva: a case report and review of the literature
Collegium Antropologicum, 35 (2011), 2; 611-614. urn:nbn:hr:105:513951
Soldić, Željko; Murgić, Jure; Radić, Jasna; Dabelić, Nina; Jazvić, Marijana; Marić Brozić, Jasmina; Kusić, Zvonko

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Soldić, Ž., Murgić, J., Radić, J., Dabelić, N., Jazvić, M., Marić Brozić, J. & Kusić, Z. (2011). Radiation therapy in treatment of fibrodysplasia ossificans progressiva: a case report and review of the literature . Collegium Antropologicum, 35. (2), 611-614. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:513951

Soldić, Željko, et al. "Radiation therapy in treatment of fibrodysplasia ossificans progressiva: a case report and review of the literature ." Collegium Antropologicum, vol. 35, no. 2, 2011, pp. 611-614. https://urn.nsk.hr/urn:nbn:hr:105:513951

Soldić, Željko, Jure Murgić, Jasna Radić, Nina Dabelić, Marijana Jazvić, Jasmina Marić Brozić and Zvonko Kusić. "Radiation therapy in treatment of fibrodysplasia ossificans progressiva: a case report and review of the literature ." Collegium Antropologicum 35, no. 2 (2011): 611-614. https://urn.nsk.hr/urn:nbn:hr:105:513951

Soldić, Ž., et al. (2011) 'Radiation therapy in treatment of fibrodysplasia ossificans progressiva: a case report and review of the literature ', Collegium Antropologicum, 35(2), pp. 611-614. Available at: https://urn.nsk.hr/urn:nbn:hr:105:513951 (Accessed 02 December 2024)

Soldić Ž, Murgić J, Radić J, Dabelić N, Jazvić M, Marić Brozić J, and sur.. Radiation therapy in treatment of fibrodysplasia ossificans progressiva: a case report and review of the literature . Collegium Antropologicum [Internet]. 2011 June [cited 2024 December 02];35(2):611-614. Available at: https://urn.nsk.hr/urn:nbn:hr:105:513951

Ž. Soldić, et al., "Radiation therapy in treatment of fibrodysplasia ossificans progressiva: a case report and review of the literature ", Collegium Antropologicum, vol. 35, no. 2, pp. 611-614, June 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:513951. [Accessed: 02 December 2024]

Metadata
Title (english)Radiation therapy in treatment of fibrodysplasia ossificans progressiva: a case report and review of the literature
Title (croatian)Radioterapija u liječenju progresivne osificirajuće fibrodisplazije: prikaz slučaja i pregled literature
AuthorŽeljko Soldić
AuthorJure Murgić
AuthorJasna Radić
AuthorNina Dabelić
AuthorMarijana Jazvić
AuthorJasmina Marić Brozić
AuthorZvonko Kusić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Fibrodysplasia ossificans progressiva (FOP) is an extremely rare genetic disorder with diffuse extra-skeletal bone formation. The genetic mutation responsible for FOP has recently been discovered and is connected with excessive activation of bone morphogenetic protein receptor. This disease usually begins with typical ossification pattern in early childhood, causing increasing disability and making patients totally disabled by the age of 30. Ectopic ossification develops spontaneously and can be triggered by any trauma and even intramuscular injections. The symptoms of FOP are often misdiagnosed as cancer, causing unnecessary biopsies, which can precipitate further progressive heterotopic ossification. There is no effective treatment for this severe condition. Radiotherapy can be helpful in impeding ossification, although the strict evidence for that is lacking. There are only two reports in the literature referring to the use of radiotherapy in treatment of FOP. Herein, we present a 35-year-old patient successfully treated with small doses of fractionated radiotherapy in several courses. This case indicates that radiotherapy can be useful in treating patients with FOP.
Abstract (croatian)
Fibrodysplasia ossificans progressiva (FOP) vrlo je rijetki genetski poremećaj kojeg karakterizira difuzno ekstraskeletalno stvaranje kosti. Genetska mutacija odgovorna za nastanak FOP-a je nedavno otkrivena i povezana je s prekomjernom aktivnosti receptora za koštani morfogenetski protein. Ta bolest obično počinje u ranom djetinjstvu tipičnim načinom okoštavanja, uzrokujući progresivnu onemoćalost, tako da bolesnici postaju potpuni invalidi do dobi od 30 godina. Ektopično okoštavanje se razvija spontano i može biti uzrokovano bilo kakvom vrstom traume, čak i intramuskularnim injekcijama. Simptomi FOP-a se često krivo dijagnosticiraju kao rak, uzrokujući nepotrebne biopsije, što precipitira daljnje opsežno ektopično okoštavanje. Nema učinkovitog liječenja za ovo teško stanje. Radioterapija može biti korisna u usporavanju okoštavanja, iako nema čvrstih dokaza za to. Postoje samo dva literaturna izvještaja koji se odnose na korištenje radioterapije u liječenju FOP-a. U ovom radu prikazuje se slučaj 35-godišnje bolesnice koja je uspješno liječena malim dozama frakcionirane radioterapije. Ovaj slučaj upućuje na činjenicu da radioterapija može biti korisna u liječenju bolesnika sa FOP-om.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 35, no. 2, pp. 611-614
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:513951
Publication2011-06
Document URLhttps://hrcak.srce.hr/69161
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:14:42