prikaz prve stranice dokumenta Periacinar retraction clefting and d2-40 expression in prostatic adenocarcinoma
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Scientific paper - Original scientific paper
Periacinar retraction clefting and d2-40 expression in prostatic adenocarcinoma
Pathology Oncology Research, 18 (2012), 2; 365-370. https://doi.org/10.1007/s12253-011-9453-0
Ulamec, Monika; Džombeta, Tihana; Čupić, Hrvoje; Leniček, Tanja; Tomas, Davor; Krušlin, Božo

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Ulamec, M., Džombeta, T., Čupić, H., Leniček, T., Tomas, D. & Krušlin, B. (2012). Periacinar retraction clefting and d2-40 expression in prostatic adenocarcinoma. Pathology Oncology Research, 18. (2), 365-370. doi: 10.1007/s12253-011-9453-0

Ulamec, Monika, et al. "Periacinar retraction clefting and d2-40 expression in prostatic adenocarcinoma." Pathology Oncology Research, vol. 18, no. 2, 2012, pp. 365-370. https://doi.org/10.1007/s12253-011-9453-0

Ulamec, Monika, Tihana Džombeta, Hrvoje Čupić, Tanja Leniček, Davor Tomas and Božo Krušlin. "Periacinar retraction clefting and d2-40 expression in prostatic adenocarcinoma." Pathology Oncology Research 18, no. 2 (2012): 365-370. https://doi.org/10.1007/s12253-011-9453-0

Ulamec, M., et al. (2012) 'Periacinar retraction clefting and d2-40 expression in prostatic adenocarcinoma', Pathology Oncology Research, 18(2), pp. 365-370. doi: 10.1007/s12253-011-9453-0

Ulamec M, Džombeta T, Čupić H, Leniček T, Tomas D, Krušlin B. Periacinar retraction clefting and d2-40 expression in prostatic adenocarcinoma. Pathology Oncology Research [Internet]. 2012 April [cited 2024 December 27];18(2):365-370. doi: 10.1007/s12253-011-9453-0

M. Ulamec, T. Džombeta, H. Čupić, T. Leniček, D. Tomas and B. Krušlin, "Periacinar retraction clefting and d2-40 expression in prostatic adenocarcinoma", Pathology Oncology Research, vol. 18, no. 2, pp. 365-370, April 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:760462. [Accessed: 27 December 2024]

Metadata
Title (english)Periacinar retraction clefting and d2-40 expression in prostatic adenocarcinoma
AuthorMonika Ulamec
AuthorTihana Džombeta
AuthorHrvoje Čupić
AuthorTanja Leniček
AuthorDavor Tomas
AuthorBožo Krušlin
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Retraction clefting is known to appear in various types of tumors, but it has only recently been recognized as a specific histological phenomenon. Previously, it was considered merely a laboratory procedure artifact, but lately, there have been some assumptions that peritumoral retractions actually represent lymphatic spaces. In our study, we analyzed neoplastic glands in 52 specimens of prostatic adenocarcinoma. Immunohistochemical analysis was performed using D2-40 antibody, to highlight lymphatic endothelium and thereby differentiate actual lymph vessels or lymphovascular invasion from periacinar retractions. Our results showed that the number of lymph vessels was significantly lower in tumorous tissue compared to adjacent normal prostatic tissue. On the other hand, the number of lymph vessels in tumorous tissue was significantly higher than the number of lymph vessels mimicking periacinar retractions. Overall, the number of lymph vessels mimicking periacinar clefts was particularly low. These results are in accordance with our previous studies, which had shown that periacinar clefting appears due to lack of basal cells and stromal changes around tumorous acini. Also, these results support our hypothesis that retractions do not represent lymph vessels but should be considered a distinct entity, which is proven to be helpful both as diagnostic and predictive factor.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titlePathology Oncology Research
Numberingvol. 18, no. 2, pp. 365-370
p-ISSN1219-4956
DOIhttps://doi.org/10.1007/s12253-011-9453-0
URN:NBNurn:nbn:hr:105:760462
Publication2012-04
Document URLhttps://doi.org/10.1007/s12253-011-9453-0
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:27:06