prikaz prve stranice dokumenta Comparison of analgesic effects of single versus repeated injection of botulinum toxin in orofacial formalin test in rats
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Scientific paper - Preliminary note / Short communication
Comparison of analgesic effects of single versus repeated injection of botulinum toxin in orofacial formalin test in rats
Journal of Neural Transmission, 120 (2013), 1; 141-144. https://doi.org/10.1007/s00702-012-0846-3
Matak, Ivica; Stracenski, Ivana; Lacković, Zdravko

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Matak, I., Stracenski, I. & Lacković, Z. (2013). Comparison of analgesic effects of single versus repeated injection of botulinum toxin in orofacial formalin test in rats. Journal of Neural Transmission, 120. (1), 141-144. doi: 10.1007/s00702-012-0846-3

Matak, Ivica, et al. "Comparison of analgesic effects of single versus repeated injection of botulinum toxin in orofacial formalin test in rats." Journal of Neural Transmission, vol. 120, no. 1, 2013, pp. 141-144. https://doi.org/10.1007/s00702-012-0846-3

Matak, Ivica, Ivana Stracenski and Zdravko Lacković. "Comparison of analgesic effects of single versus repeated injection of botulinum toxin in orofacial formalin test in rats." Journal of Neural Transmission 120, no. 1 (2013): 141-144. https://doi.org/10.1007/s00702-012-0846-3

Matak, I., Stracenski, I. and Lacković, Z. (2013) 'Comparison of analgesic effects of single versus repeated injection of botulinum toxin in orofacial formalin test in rats', Journal of Neural Transmission, 120(1), pp. 141-144. doi: 10.1007/s00702-012-0846-3

Matak I, Stracenski I, Lacković Z. Comparison of analgesic effects of single versus repeated injection of botulinum toxin in orofacial formalin test in rats. Journal of Neural Transmission [Internet]. 2013 January [cited 2024 December 26];120(1):141-144. doi: 10.1007/s00702-012-0846-3

I. Matak, I. Stracenski and Z. Lacković, "Comparison of analgesic effects of single versus repeated injection of botulinum toxin in orofacial formalin test in rats", Journal of Neural Transmission, vol. 120, no. 1, pp. 141-144, January 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:186109. [Accessed: 26 December 2024]

Metadata
Title (english)Comparison of analgesic effects of single versus repeated injection of botulinum toxin in orofacial formalin test in rats
AuthorIvica Matak
AuthorIvana Stracenski
AuthorZdravko Lacković
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Long-term effectiveness and repeated administration of botulinum toxin A are the basis for its use in both neuromuscular disorders and certain painful conditions. Botulinum toxin A has been recently approved for migraine treatment, and its off-label use extends to other craniofacial pain disorders. However, recently it was reported that, after repeated injection, botulinum toxin loses its antinociceptive efficacy in rats. In present study with a similar design, we compared the effects of single and repeated injections of botulinum toxin in formalin-induced orofacial pain. No statistically significant differences were found between single or repeatedly treated animal groups. Our results are in line with the clinical experience and suggest that botulinum toxin can be re-administered in orofacial pain treatment.
Keywords (english)
Languageenglish
Publication typeScientific paper - Preliminary note / Short communication
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Neural Transmission
Numberingvol. 120, no. 1, pp. 141-144
p-ISSN0300-9564
DOIhttps://doi.org/10.1007/s00702-012-0846-3
URN:NBNurn:nbn:hr:105:186109
Publication2013-01
Document URLhttps://doi.org/10.1007/s00702-012-0846-3
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:35:53