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Scientific paper - Original scientific paper
Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes
Metabolic Brain Disease, 27 (2012), 4; 507-512. https://doi.org/10.1007/s11011-012-9310-1
Mustapić, Maja; Popović Hadžija, Marijana; Pavlović, Mladen; Pavković, Pajica; Presečki, Paola; Mrazovac, Danijela; Mimica, Ninoslav; Korolija, Marina; Pivac, Nela; Muck-Šeler, Dorotea

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Mustapić, M., Popović Hadžija, M., Pavlović, M., Pavković, P., Presečki, P., Mrazovac, D. ... Muck Šeler, D. (2012). Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes . Metabolic Brain Disease, 27. (4), 507-512. doi: 10.1007/s11011-012-9310-1

Mustapić, Maja, et al. "Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes ." Metabolic Brain Disease, vol. 27, no. 4, 2012, pp. 507-512. https://doi.org/10.1007/s11011-012-9310-1

Mustapić, Maja, Marijana Popović Hadžija, Mladen Pavlović, Pajica Pavković, Paola Presečki, Danijela Mrazovac, Ninoslav Mimica, Marina Korolija, Nela Pivac and Dorotea Muck Šeler. "Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes ." Metabolic Brain Disease 27, no. 4 (2012): 507-512. https://doi.org/10.1007/s11011-012-9310-1

Mustapić, M., et al. (2012) 'Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes ', Metabolic Brain Disease, 27(4), pp. 507-512. doi: 10.1007/s11011-012-9310-1

Mustapić M, Popović Hadžija M, Pavlović M, Pavković P, Presečki P, Mrazovac D, and sur.. Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes . Metabolic Brain Disease [Internet]. 2012 December [cited 2024 May 03];27(4):507-512. doi: 10.1007/s11011-012-9310-1

M. Mustapić, et al., "Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes ", Metabolic Brain Disease, vol. 27, no. 4, pp. 507-512, December 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:834524. [Accessed: 03 May 2024]

Metadata
Title (english)Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes
AuthorMaja Mustapić
AuthorMarijana Popović Hadžija
AuthorMladen Pavlović
AuthorPajica Pavković
AuthorPaola Presečki
AuthorDanijela Mrazovac
AuthorNinoslav Mimica
AuthorMarina Korolija
AuthorNela Pivac
AuthorDorotea Muck-Šeler
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two progressive disorders with high prevalence worldwide. Polymorphisms in tumor necrosis factor-alpha (TNF-?) and apolipoprotein E (ApoE) genes might be associated with both T2D and AD, representing possible genetic markers for the development of the AD in subjects with T2D. The aim was to determine ApoE and G-308A TNF-? gene polymorphisms in unrelated Croatian Caucasians: 207 patients with sporadic AD, 196 T2D patients and 456 healthy controls. Patients with AD had higher frequency of ApoE4 allele compared to T2D patients and controls. The significant association, observed between ApoE2 allele and T2D, disappeared after the data were adjusted for age and sex. The genotype or allele frequencies of G-308A TNF-? gene polymorphism were similar among the patients with AD, T2D and healthy controls. In conclusion, these results do not support the hypothesis that the A allele of G-308A TNF-? gene polymorphism is associated either with AD or T2D. Our data confirm the association between the ApoE4 allele and AD, and point out the E2 allele of ApoE gene as the possible risk factor for T2D.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleMetabolic Brain Disease
Numberingvol. 27, no. 4, pp. 507-512
p-ISSN0885-7490
DOIhttps://doi.org/10.1007/s11011-012-9310-1
URN:NBNurn:nbn:hr:105:834524
Publication2012-12
Document URLhttps://doi.org/10.1007/s11011-012-9310-1
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:36:24