prikaz prve stranice dokumenta Prognostic significance of glomerular and tubulointerstitial morphometry in idiopathic membranous nephropathy
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Scientific paper - Original scientific paper
Prognostic significance of glomerular and tubulointerstitial morphometry in idiopathic membranous nephropathy
Pathology, Research and Practice, 208 (2012), 11; 662-667. https://doi.org/10.1016/j.prp.2012.08.004
Horvatić, Ivica; Galešić Ljubanović, Danica; Bulimbašić, Stela; Knotek, Mladen; Prkačin, Ingrid; Tišljar, Miroslav; Galešić, Krešimir

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Horvatić, I., Galešić Ljubanović, D., Bulimbašić, S., Knotek, M., Prkačin, I., Tišljar, M. & Galešić, K. (2012). Prognostic significance of glomerular and tubulointerstitial morphometry in idiopathic membranous nephropathy. Pathology, Research and Practice, 208. (11), 662-667. doi: 10.1016/j.prp.2012.08.004

Horvatić, Ivica, et al. "Prognostic significance of glomerular and tubulointerstitial morphometry in idiopathic membranous nephropathy." Pathology, Research and Practice, vol. 208, no. 11, 2012, pp. 662-667. https://doi.org/10.1016/j.prp.2012.08.004

Horvatić, Ivica, Danica Galešić Ljubanović, Stela Bulimbašić, Mladen Knotek, Ingrid Prkačin, Miroslav Tišljar and Krešimir Galešić. "Prognostic significance of glomerular and tubulointerstitial morphometry in idiopathic membranous nephropathy." Pathology, Research and Practice 208, no. 11 (2012): 662-667. https://doi.org/10.1016/j.prp.2012.08.004

Horvatić, I., et al. (2012) 'Prognostic significance of glomerular and tubulointerstitial morphometry in idiopathic membranous nephropathy', Pathology, Research and Practice, 208(11), pp. 662-667. doi: 10.1016/j.prp.2012.08.004

Horvatić I, Galešić Ljubanović D, Bulimbašić S, Knotek M, Prkačin I, Tišljar M, and sur.. Prognostic significance of glomerular and tubulointerstitial morphometry in idiopathic membranous nephropathy. Pathology, Research and Practice [Internet]. 2012 November 15 [cited 2024 November 05];208(11):662-667. doi: 10.1016/j.prp.2012.08.004

I. Horvatić, et al., "Prognostic significance of glomerular and tubulointerstitial morphometry in idiopathic membranous nephropathy", Pathology, Research and Practice, vol. 208, no. 11, pp. 662-667, November 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:547632. [Accessed: 05 November 2024]

Metadata
Title (english)Prognostic significance of glomerular and tubulointerstitial morphometry in idiopathic membranous nephropathy
AuthorIvica Horvatić
AuthorDanica Galešić Ljubanović
AuthorStela Bulimbašić
AuthorMladen Knotek
AuthorIngrid Prkačin
AuthorMiroslav Tišljar
AuthorKrešimir Galešić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The purpose of our study was to investigate the prognostic value of clinical and pathological, in particular glomerular and tubulointerstitial morphometric variables in idiopathic membranous nephropathy (IMN). We prospectively followed 60 Caucasian patients diagnosed with idiopathic membranous nephropathy for at least 2 years or until primary outcome (≥50% permanent decrease in estimated glomerular filtration rate or death). Glomerular and tubulointerstitial morphometric variables at the time of renal biopsy were analyzed with respect to this outcome. Univariate analysis revealed that significant negative prognostic factors for this outcome were higher cholesterol and smaller albumin concentrations, higher creatinine and maximal 24-h proteinuria, higher grade of nephroangiosclerosis, higher glomerular basement membrane thickness and glomerulopathy index, higher interstitial fibrosis and tubular atrophy percentage and higher injury score. In multivariate analysis, only the maximal 24-h proteinuria and interstitial fibrosis and tubular atrophy percentage were independent predictors of this outcome. The results suggest that morphometric analysis, mainly quantitative measurement of interstitial fibrosis and tubular atrophy percentage, injury score, glomerular basement membrane thickness and glomerulopathy index could be used as an additional method for risk stratification of patients with idiopathic membranous nephropathy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titlePathology, Research and Practice
Numberingvol. 208, no. 11, pp. 662-667
p-ISSN0344-0338
DOIhttps://doi.org/10.1016/j.prp.2012.08.004
URN:NBNurn:nbn:hr:105:547632
Publication2012-11-15
Document URLhttps://doi.org/10.1016/j.prp.2012.08.004
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:41:30