prikaz prve stranice dokumenta Dual antiplatelet therapy in patients with aspirin resistance following coronary artery bypass grafting: study protocol for a randomized controlled trial
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Scientific paper - Original scientific paper
Dual antiplatelet therapy in patients with aspirin resistance following coronary artery bypass grafting: study protocol for a randomized controlled trial
Trials, 13 (2012), 148; https://doi.org/10.1186/1745-6215-13-148
Gašparović, Hrvoje; Petričević, Mate; Kopjar, Tomislav; Đurić, Željko; Svetina, Lucija; Biočina, Bojan

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Gašparović, H., Petričević, M., Kopjar, T., Đurić, Ž., Svetina, L. & Biočina, B. (2012). Dual antiplatelet therapy in patients with aspirin resistance following coronary artery bypass grafting: study protocol for a randomized controlled trial . Trials, 13. (148). doi: 10.1186/1745-6215-13-148

Gašparović, Hrvoje, et al. "Dual antiplatelet therapy in patients with aspirin resistance following coronary artery bypass grafting: study protocol for a randomized controlled trial ." Trials, vol. 13, no. 148, 2012. https://doi.org/10.1186/1745-6215-13-148

Gašparović, Hrvoje, Mate Petričević, Tomislav Kopjar, Željko Đurić, Lucija Svetina and Bojan Biočina. "Dual antiplatelet therapy in patients with aspirin resistance following coronary artery bypass grafting: study protocol for a randomized controlled trial ." Trials 13, no. 148 (2012). https://doi.org/10.1186/1745-6215-13-148

Gašparović, H., et al. (2012) 'Dual antiplatelet therapy in patients with aspirin resistance following coronary artery bypass grafting: study protocol for a randomized controlled trial ', Trials, 13(148). doi: 10.1186/1745-6215-13-148

Gašparović H, Petričević M, Kopjar T, Đurić Ž, Svetina L, Biočina B. Dual antiplatelet therapy in patients with aspirin resistance following coronary artery bypass grafting: study protocol for a randomized controlled trial . Trials [Internet]. 2012 August 25 [cited 2024 May 01];13(148). doi: 10.1186/1745-6215-13-148

H. Gašparović, M. Petričević, T. Kopjar, Ž. Đurić, L. Svetina and B. Biočina, "Dual antiplatelet therapy in patients with aspirin resistance following coronary artery bypass grafting: study protocol for a randomized controlled trial ", Trials, vol. 13, no. 148, August 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:611554. [Accessed: 01 May 2024]

Metadata
Title (english)Dual antiplatelet therapy in patients with aspirin resistance following coronary artery bypass grafting: study protocol for a randomized controlled trial
Title (croatian)NCT01159639
AuthorHrvoje Gašparović
AuthorMate Petričević
AuthorTomislav Kopjar
AuthorŽeljko Đurić
AuthorLucija Svetina
AuthorBojan Biočina
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: Coronary artery disease remains the dominant cause of mortality in developed countries. While platelets have been recognized to play a pivotal role in atherothrombosis, the ideal antiplatelet regime after coronary artery surgery remains elusive. The evolution of CABG has presently moved beyond technical improvements to involve modulation of pharmacologic management designed to improve patient outcomes. The aim of this trial will be to test the hypothesis that the addition of clopidogrel to patients with documented postoperative aspirin resistance will reduce the incidence of major cardiovascular events. ----- METHODS: Patients scheduled for isolated coronary artery surgery will be eligible for the study. Patients in whom postoperative multiple electrode aggregometry documents aspirin resistance will be randomized into two groups. The control group will receive 300 mg of aspirin. The dual antiplatelet group will receive 75 mg of clopidogrel in addition to 300 mg of aspirin. Patients will be followed for 6 months. Major adverse cardiac and cerebrovascular events (death from any cause, myocardial infarction, stroke, hospitalization due to cardiovascular pathology) as well as bleeding events will be recorded. ----- DISCUSSION: This will be the first trial that will specifically address the issue of dual antiplatelet therapy in patients undergoing coronary artery surgery who have been found to be aspirin resistant. In the event that the addition of clopidogrel proves to be beneficial in this subset of surgical patients, this study could significantly impact their future antiplatelet management. This randomized controlled trial has been registered at the ClinicalTrials.gov website (Identifier NCT01159639).
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleTrials
Numberingvol. 13, no. 148
p-ISSN1745-6215
DOIhttps://doi.org/10.1186/1745-6215-13-148
URN:NBNurn:nbn:hr:105:611554
Publication2012-08-25
Document URLhttps://doi.org/10.1186/1745-6215-13-148
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:43:15