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Scientific paper - Original scientific paper
Clinical and patohistological factors affecting the 5 year survival rate in a population of Croatian women with invasive ductal breast carcinoma
Collegium Antropologicum, 37 (2013), 2; 459-464. urn:nbn:hr:105:717334
Milanović, Rudolf; Roje, Željka; Korušić, Anđelko; Tudorić Đeno, Ivana; Barić, Ada; Stanec, Zdenko

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Milanović, R., Roje, Ž., Korušić, A., Tudorić Đeno, I., Barić, A. & Stanec, Z. (2013). Clinical and patohistological factors affecting the 5 year survival rate in a population of Croatian women with invasive ductal breast carcinoma . Collegium Antropologicum, 37. (2), 459-464. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:717334

Milanović, Rudolf, et al. "Clinical and patohistological factors affecting the 5 year survival rate in a population of Croatian women with invasive ductal breast carcinoma ." Collegium Antropologicum, vol. 37, no. 2, 2013, pp. 459-464. https://urn.nsk.hr/urn:nbn:hr:105:717334

Milanović, Rudolf, Željka Roje, Anđelko Korušić, Ivana Tudorić Đeno, Ada Barić and Zdenko Stanec. "Clinical and patohistological factors affecting the 5 year survival rate in a population of Croatian women with invasive ductal breast carcinoma ." Collegium Antropologicum 37, no. 2 (2013): 459-464. https://urn.nsk.hr/urn:nbn:hr:105:717334

Milanović, R., et al. (2013) 'Clinical and patohistological factors affecting the 5 year survival rate in a population of Croatian women with invasive ductal breast carcinoma ', Collegium Antropologicum, 37(2), pp. 459-464. Available at: https://urn.nsk.hr/urn:nbn:hr:105:717334 (Accessed 05 May 2024)

Milanović R, Roje Ž, Korušić A, Tudorić Đeno I, Barić A, Stanec Z. Clinical and patohistological factors affecting the 5 year survival rate in a population of Croatian women with invasive ductal breast carcinoma . Collegium Antropologicum [Internet]. 2013 June [cited 2024 May 05];37(2):459-464. Available at: https://urn.nsk.hr/urn:nbn:hr:105:717334

R. Milanović, Ž. Roje, A. Korušić, I. Tudorić Đeno, A. Barić and Z. Stanec, "Clinical and patohistological factors affecting the 5 year survival rate in a population of Croatian women with invasive ductal breast carcinoma ", Collegium Antropologicum, vol. 37, no. 2, pp. 459-464, June 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:717334. [Accessed: 05 May 2024]

Metadata
Title (english)Clinical and patohistological factors affecting the 5 year survival rate in a population of Croatian women with invasive ductal breast carcinoma
Title (croatian)Klinički i patohistološki čimbenici koji utječu na petogodišnju stopu preživljavanja u populaciji žena s invazivnim duktalnim karcinomom dojke u Hrvatskoj
AuthorRudolf Milanović
AuthorŽeljka Roje
AuthorAnđelko Korušić
AuthorIvana Tudorić Đeno
AuthorAda Barić
AuthorZdenko Stanec
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Breast carcinoma falls into a heterogeneous group of diseases which can be determined by various prognostic factors. The identification of clinical and histopathologic factors is of great value in predicting the progression of tumor growth and survival outcome. Due to a high degree of cell proliferation in breast tumors and high genetic instability of these tumors, as a consequence of defective DNA repair mechanisms, chemotherapy as a treatment option often renders very successful results. During our scientific study of the expression of genes responsible for mismatch repair of DNA in cells of invasive ductal carcinoma we also compared the patient survival rate with the major prognostic factors. This study included 108 patients who were surgically treated for invasive breast cancer at the Department of Plastic, Reconstructive and Aesthetic Surgery, University Hospital "Dubrava". The overall survival rate was compared to factors such as initial tumor stage, regional lymph node involvement and distant metastasis. The overall five year survival rate of our patients was 78.7%. Patients without the presence of distant metastasis, a lower rate of local lymph node involvement and a lower. tumor stage statistically had a longer overall survival period. It is important that physicians recognize the various clinico-pathohistological factors in patients with breast carcinoma. This study confirms that this prognostic factors determine the type of treatment required and most important, the patient overall survival period.
Abstract (croatian)
Karcinom dojke spada u heterogenu grupu bolesti na koju utječu mnogi prognostički čimbenici. Identifikacija kliničkih i patohistoloških čimbenika je od velike važnosti u predviđanju progresije tumorskog rasta i stope preživljena pacijentica. Zbog visokog stupnja proliferacije stanica tumora dojke i genetske nestabilnosti tih tumora, kao posljedice nepravilnog mehanizma za popravak oštećenja DNA, kemoterapija kao terapijska opcija daje vrlo dobre rezultate. U sklopu istraživanja ekspresije gena odgovornih za popravak krivo sparenih baza u molekuli DNA u stanicama invazivnog duktalni karcinoma, provedena je i usporedba stope preživljenja i glavnih prognostičkih čimbenika. U ovo istraživanje uključeno je 108 pacijentica koje su kirurški liječene zbog invazivnog karcinoma dojke na Klinici za plastičnu, rekonstruktivnu i estetsku kirurgiju, KB »Dubrava«. Ukupna stopa preživljenja promatrana je u odnosu na početni stadij tumora, prisutnost regionalnih metastaza u limfnim čvorovima i udaljenih metastaza. Ukupna petogodišnja stopa preživljenja naših pacijenata bila je 78,7%. Pacijentice bez prisutnosti udaljenih metastaza, manjim stupnjem zahvaćenosti limfnih čvorova i nižim stadijem tumora statistički su imale bolju stopu preživljenja. Ova studija potvrđuje da navedeni prognostički čimbenici određuju način liječenja i najvažnije, utječu na preživljenje pacijentica.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 37, no. 2, pp. 459-464
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:717334
Publication2013-06
Document URLhttps://hrcak.srce.hr/104483
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:49:39