prikaz prve stranice dokumenta Single nucleotide polymorphisms in the interleukin-6 gene promoter, tumor necrosis factor-alpha gene promoter, and transforming growth factor-beta 1 gene signal sequence as predictors of time to onset of aseptic loosening after total hip arthroplasty: pre
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Scientific paper - Original scientific paper
Single nucleotide polymorphisms in the interleukin-6 gene promoter, tumor necrosis factor-alpha gene promoter, and transforming growth factor-beta 1 gene signal sequence as predictors of time to onset of aseptic loosening after total hip arthroplasty: preliminary study
Journal of Orthopaedic Science, 11 (2006), 6; 592-600. https://doi.org/doi: 10.1007/s00776-006-1069-y
Kolundžić, Robert; Orlić, Dubravko; Trkulja, Vladimir; Pavelić, Krešimir; Gall Trošelj, Koraljka

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Kolundžić, R., Orlić, D., Trkulja, V., Pavelić, K. & Gall Trošelj, K. (2006). Single nucleotide polymorphisms in the interleukin-6 gene promoter, tumor necrosis factor-alpha gene promoter, and transforming growth factor-beta 1 gene signal sequence as predictors of time to onset of aseptic loosening after total hip arthroplasty: preliminary study. Journal of Orthopaedic Science, 11. (6), 592-600. doi: doi: 10.1007/s00776-006-1069-y

Kolundžić, Robert, et al. "Single nucleotide polymorphisms in the interleukin-6 gene promoter, tumor necrosis factor-alpha gene promoter, and transforming growth factor-beta 1 gene signal sequence as predictors of time to onset of aseptic loosening after total hip arthroplasty: preliminary study." Journal of Orthopaedic Science, vol. 11, no. 6, 2006, pp. 592-600. https://doi.org/doi: 10.1007/s00776-006-1069-y

Kolundžić, Robert, Dubravko Orlić, Vladimir Trkulja, Krešimir Pavelić and Koraljka Gall Trošelj. "Single nucleotide polymorphisms in the interleukin-6 gene promoter, tumor necrosis factor-alpha gene promoter, and transforming growth factor-beta 1 gene signal sequence as predictors of time to onset of aseptic loosening after total hip arthroplasty: preliminary study." Journal of Orthopaedic Science 11, no. 6 (2006): 592-600. https://doi.org/doi: 10.1007/s00776-006-1069-y

Kolundžić, R., et al. (2006) 'Single nucleotide polymorphisms in the interleukin-6 gene promoter, tumor necrosis factor-alpha gene promoter, and transforming growth factor-beta 1 gene signal sequence as predictors of time to onset of aseptic loosening after total hip arthroplasty: preliminary study', Journal of Orthopaedic Science, 11(6), pp. 592-600. doi: doi: 10.1007/s00776-006-1069-y

Kolundžić R, Orlić D, Trkulja V, Pavelić K, Gall Trošelj K. Single nucleotide polymorphisms in the interleukin-6 gene promoter, tumor necrosis factor-alpha gene promoter, and transforming growth factor-beta 1 gene signal sequence as predictors of time to onset of aseptic loosening after total hip arthroplasty: preliminary study. Journal of Orthopaedic Science [Internet]. 2006 November [cited 2024 May 03];11(6):592-600. doi: doi: 10.1007/s00776-006-1069-y

R. Kolundžić, D. Orlić, V. Trkulja, K. Pavelić and K. Gall Trošelj, "Single nucleotide polymorphisms in the interleukin-6 gene promoter, tumor necrosis factor-alpha gene promoter, and transforming growth factor-beta 1 gene signal sequence as predictors of time to onset of aseptic loosening after total hip arthroplasty: preliminary study", Journal of Orthopaedic Science, vol. 11, no. 6, pp. 592-600, November 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:345305. [Accessed: 03 May 2024]

Metadata
Title (english)Single nucleotide polymorphisms in the interleukin-6 gene promoter, tumor necrosis factor-alpha gene promoter, and transforming growth factor-beta 1 gene signal sequence as predictors of time to onset of aseptic loosening after total hip arthroplasty: preliminary study
AuthorRobert Kolundžić
AuthorDubravko Orlić
AuthorVladimir Trkulja
AuthorKrešimir Pavelić
AuthorKoraljka Gall Trošelj
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: Aseptic loosening resulting from inflammatory response to the implant wear debris is the major cause of late total hip arthroplasty (THA) failure. We examined single nucleotide polymorphisms in genes encoding for three involved cytokines - interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor-beta1 (TGF-beta1) - as potential predictors of time to onset of aseptic instability. - - - - - METHODS: A total of 41 patients/45 total hip endoprostheses (same type, same surgeon) were followed up for as long as 18 years. They were genotyped for the IL-6 promoter (-597G-->A) and (-572G-->C), TNF-alpha promoter (-308G-->A), and TGF-beta1 signal sequence ((29)T-->C) transitions. Cox regression was performed on the prosthesis survival. - - - - - RESULTS: Overall, 22 of 45 prostheses developed aseptic instability. Cumulative survivals at 10 and 15 years after THA were 95.6% and 66.6%, respectively. The effect of a particular polymorphic site was estimated with adjustment for sex, age at THA, reason for THA, and the effects of other analyzed sites. The hazard ratio (HR) for genotype T/T versus "C-allele carriage" at the TGF-beta1 site was 8.23 [95% confidence interval (CI) 1.45-46.8] (P = 0.017) or 5.70 (1.39-23.4) (P = 0.016) when the IL-6 promoter sites were considered as a "combination of genotypes (-597) | (-572)." The most prevalent combination of genotypes at IL-6 sites was G/A (-597) | C/C (-572). HR for this combination (versus other combinations) was 5.43 (1.73-17.0) (P = 0.004) when "TGF-beta1 ((29)T-->C)" was considered as a three-level factor (three possible genotypes), and 4.92 (1.71-14.1) (P = 0.003) when TGF-beta1 site was considered as a two-level factor (T/T and "C-allele carriage"). The HR for the "A-allele carriage" at TNF-alpha (-308G-->A) could not be determined (only two patients had the G/G genotype). - - - - - CONCLUSIONS: This preliminary study is the first to suggest that the TGF-beta1 signal sequence ((29)T-->C) and IL-6 promoter (-597G-->A) | (-572G-->C) transitions are predictive for the time to onset of aseptic instability after THA.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Orthopaedic Science
Numberingvol. 11, no. 6, pp. 592-600
p-ISSN0949-2658
DOIhttps://doi.org/doi: 10.1007/s00776-006-1069-y
URN:NBNurn:nbn:hr:105:345305
Publication2006-11
Document URLhttps://doi.org/10.1007/s00776-006-1069-y
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:57:20