prikaz prve stranice dokumenta MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients
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Scientific paper - Original scientific paper
MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients
BMC Gastroenterology, 13 (2013), 1; 57. https://doi.org/10.1186/1471-230X-13-57
Brinar, Marko; Čuković-Čavka, Silvija; Božina, Nada; Grubelić Ravić, Katja; Markoš, Pave; Ladić, Agata; Cota, Marijana; Krznarić, Željko; Vucelić, Boris

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Brinar, M., Čuković Čavka, S., Božina, N., Grubelić Ravić, K., Markoš, P., Ladić, A. ... Vucelić, B. (2013). MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients. BMC Gastroenterology, 13. (1), 57. doi: 10.1186/1471-230X-13-57

Brinar, Marko, et al. "MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients." BMC Gastroenterology, vol. 13, no. 1, 2013, p. 57. https://doi.org/10.1186/1471-230X-13-57

Brinar, Marko, Silvija Čuković Čavka, Nada Božina, Katja Grubelić Ravić, Pave Markoš, Agata Ladić, Marijana Cota, Željko Krznarić and Boris Vucelić. "MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients." BMC Gastroenterology 13, no. 1 (2013): 57. https://doi.org/10.1186/1471-230X-13-57

Brinar, M., et al. (2013) 'MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients', BMC Gastroenterology, 13(1), p. 57. doi: 10.1186/1471-230X-13-57

Brinar M, Čuković Čavka S, Božina N, Grubelić Ravić K, Markoš P, Ladić A, and sur.. MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients. BMC Gastroenterology [Internet]. 2013 March 27 [cited 2024 November 26];13(1):57. doi: 10.1186/1471-230X-13-57

M. Brinar, et al., "MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients", BMC Gastroenterology, vol. 13, no. 1, p. 57, March 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:357896. [Accessed: 26 November 2024]

Metadata
Title (english)MDR1 polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients
AuthorMarko Brinar
AuthorSilvija Čuković-Čavka
AuthorNada Božina
AuthorKatja Grubelić Ravić
AuthorPave Markoš
AuthorAgata Ladić
AuthorMarijana Cota
AuthorŽeljko Krznarić
AuthorBoris Vucelić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: Inflammatory bowel diseases (IBD) are chronic diseases of unknown etiology and pathogenesis in which genetic factors contribute to development of disease. MDR1/ABCB1 is an interesting candidate gene for IBD. The role of two single nucleotide polymorphisms, C3435T and G2677T remains unclear due to contradictory results of current studies. Thus, the aims of this research were to investigate the association of MDR1 polymorphisms, C3435T and G2677T, and IBD. ----- METHODS: A total of 310 IBD patients, 199 Crohn's disease (CD) patients and 109 ulcerative colitis (UC) patients, and 120 healthy controls were included in the study. All subjects were genotyped for G2677T/A and C3435T polymorphism using RT-PCR. In IBD patients, review of medical records was performed and patients were phenotyped according to the Montreal classification. ----- RESULTS: Significantly higher frequency of 2677T allele (p=0.05; OR 1.46, 95% CI (1.0-2.14)) and of the 3435TT genotype was observed among UC patients compared to controls (p=0.02; OR 2.12; 95% CI (1.11-4.03). Heterozygous carriers for C3435T were significantly less likely to have CD (p=0.02; OR 0.58, 95% CI (0.36-0.91)). Haplotype analysis revealed that carriers of 3435T/2677T haplotype had a significantly higher risk of having UC (p=0.02; OR 1.55; 95% CI (1.06-2.28)). ----- CONCLUSION: MDR1 polymorphisms are associated with both CD and UC with a stronger association with UC.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBMC Gastroenterology
Numberingvol. 13, no. 1, p. 57
p-ISSN1471-230X
DOIhttps://doi.org/10.1186/1471-230X-13-57
URN:NBNurn:nbn:hr:105:357896
Publication2013-03-27
Document URLhttps://doi.org/10.1186/1471-230X-13-57
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:59:25