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master's thesis
Alergijske reakcije na hranu
Zagreb: University of Zagreb, School of Medicine, 2014. urn:nbn:hr:105:252451
Šulc, Ivona
University of Zagreb
School of Medicine
Department of Internal Medicine

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Šulc, I. (2014). Alergijske reakcije na hranu (Master's thesis). Zagreb: University of Zagreb, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:252451

Šulc, Ivona. "Alergijske reakcije na hranu." Master's thesis, University of Zagreb, School of Medicine, 2014. https://urn.nsk.hr/urn:nbn:hr:105:252451

Šulc, Ivona. "Alergijske reakcije na hranu." Master's thesis, University of Zagreb, School of Medicine, 2014. https://urn.nsk.hr/urn:nbn:hr:105:252451

Šulc, I. (2014). 'Alergijske reakcije na hranu', Master's thesis, University of Zagreb, School of Medicine, accessed 10 November 2024, https://urn.nsk.hr/urn:nbn:hr:105:252451

Šulc I. Alergijske reakcije na hranu [Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2014 [cited 2024 November 10] Available at: https://urn.nsk.hr/urn:nbn:hr:105:252451

I. Šulc, "Alergijske reakcije na hranu", Master's thesis, University of Zagreb, School of Medicine, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:105:252451

Metadata
TitleAlergijske reakcije na hranu
Title (english)Food allergy
AuthorIvona Šulc
MentorAsja Stipić-Marković (mentor)
Committee memberAnte Bilić (predsjednik povjerenstva)
Committee memberJasenka Markeljević (član povjerenstva)
Committee memberAsja Stipić-Marković (član povjerenstva)
GranterUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Zagreb
Defense date and country2014-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract
Alergija na hranu zahvaća sve veći broj ljudi širom svijeta. Incidencija je veća u djece nego u odraslih. Mnogo čimbenika sudjeluje u uspostavi i održavanju imunotolerancije na alergene hrane, a ključnu ulogu imaju imunokompetentne stanice u sluznici gastrointestinalnog trakta. Mehanizam nastanka alergije na hranu danas još nije u potpunosti poznat. U nastanku alergijske upalne reakcije središnju ulogu ima aktivacija mastocita i bazofila, posredovana signaliziranjem putem visokoafinitetnog IgE receptora. Signaliziranje započinje vezanjem alergena za IgE protutijela vezana na receptor. Posljedično, unutar stanice nastaje signalna kaskada, koja dovodi do njene aktivacije i otpuštanja niza medijatora odgovornih za nastanak alergijske reakcije. Alergija na hranu može se manifestirati širokim spektrom simptoma koji mogu varirati, od kroničnih gastrointestinalnih do teških, za život opasnih, anafilaktičnih reakcija. Trenutačno ne postoji sigurna i učinkovita terapija u liječenju bolesnika s alergijom na hranu, a liječenje se temelji na eliminacijskoj dijeti koja značajno narušava kvalitetu života bolesnika.
Abstract (english)
Food allergy affects more and more people all over the world. The incidence is estimated to be greater in children than the in adults. There are several physiological mechanisms involved in driving mucosal tolerogenic response to food antigens. The immune cells in lamina propria have a key-role in this process. The central event in the formation of the allergic inflammation, the activation of mast cells and basophils, is mediated by signaling through the high-affinity IgE receptor. The signaling starts by cross-linking of receptor-bound IgE with an allergen. This initiates a cascade of signaling events that activates the cell and ultimately causes the release of mediators responsible for allergic responses. The spectrum of food allergy consists of a variety of different clinical presentations, and can range from chronic gastrointestinal symptoms to severe, life threatening, and anaphylactic reactions. Currently, there is no safe and efficient treatment for food allergy, and the treatment relies on avoidance diets, that significantly affect the quality of life of allergic patients.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:105:252451
Study programmeTitle: Medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2015-10-05 11:38:12