prikaz prve stranice dokumenta Pseudocholinesterase activity in cerebrospinal fluid as a biomarker of solid central nervous system tumors in children
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Scientific paper - Original scientific paper
Pseudocholinesterase activity in cerebrospinal fluid as a biomarker of solid central nervous system tumors in children
Croatian Medical Journal, 54 (2013), 5; 429-435. https://doi.org/10.3325/cmj.2013.54.429
Mikecin, Lili; Križmarić, Miljenko; Stepan Giljević, Jasminka; Gjurašin, Miroslav; Kern, Josipa; Leniček Krleža, Jasna; Popović, Ljiljana

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Mikecin, L., Križmarić, M., Stepan Giljević, J., Gjurašin, M., Kern, J., Leniček Krleža, J. & Popović, Lj. (2013). Pseudocholinesterase activity in cerebrospinal fluid as a biomarker of solid central nervous system tumors in children. Croatian Medical Journal, 54. (5), 429-435. doi: 10.3325/cmj.2013.54.429

Mikecin, Lili, et al. "Pseudocholinesterase activity in cerebrospinal fluid as a biomarker of solid central nervous system tumors in children." Croatian Medical Journal, vol. 54, no. 5, 2013, pp. 429-435. https://doi.org/10.3325/cmj.2013.54.429

Mikecin, Lili, Miljenko Križmarić, Jasminka Stepan Giljević, Miroslav Gjurašin, Josipa Kern, Jasna Leniček Krleža and Ljiljana Popović. "Pseudocholinesterase activity in cerebrospinal fluid as a biomarker of solid central nervous system tumors in children." Croatian Medical Journal 54, no. 5 (2013): 429-435. https://doi.org/10.3325/cmj.2013.54.429

Mikecin, L., et al. (2013) 'Pseudocholinesterase activity in cerebrospinal fluid as a biomarker of solid central nervous system tumors in children', Croatian Medical Journal, 54(5), pp. 429-435. doi: 10.3325/cmj.2013.54.429

Mikecin L, Križmarić M, Stepan Giljević J, Gjurašin M, Kern J, Leniček Krleža J, and sur.. Pseudocholinesterase activity in cerebrospinal fluid as a biomarker of solid central nervous system tumors in children. Croatian Medical Journal [Internet]. 2013 October 28 [cited 2024 November 26];54(5):429-435. doi: 10.3325/cmj.2013.54.429

L. Mikecin, et al., "Pseudocholinesterase activity in cerebrospinal fluid as a biomarker of solid central nervous system tumors in children", Croatian Medical Journal, vol. 54, no. 5, pp. 429-435, October 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:396089. [Accessed: 26 November 2024]

Metadata
Title (english)Pseudocholinesterase activity in cerebrospinal fluid as a biomarker of solid central nervous system tumors in children
AuthorLili Mikecin
AuthorMiljenko Križmarić
AuthorJasminka Stepan Giljević
AuthorMiroslav Gjurašin
AuthorJosipa Kern
AuthorJasna Leniček Krleža
AuthorLjiljana Popović
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To determine the activity of pseudocholinesterase (PChE) in cerebrospinal fluid (CSF) and serum in children with solid central nervous system (CNS) tumor and to assess whether PChE activity could be a valid biomarker for solid CNS tumors in children. ----- METHODS: The study and control group included 30 children each. Children in the study group had a solid CNS tumor, while those from the control group had never suffered from any tumor diseases. CSF and serum samples were collected from all participants and PChE activity was determined using the Ellman's spectrophotometric method. PChE activity in CSF was shown as a cerebrospinal fluid/serum ratio expressed in percentage, ie, PChE CSF/serum ratio. Receiver operating characteristic (ROC) curve was used to assess whether PChE activity can be used as a biomarker for identifying children with solid CNS tumors. ----- RESULTS: Children with solid CNS tumor had significantly higher PChE activity in CSF and serum, as well as PChE CSF/serum ratio (P=0.001). PChE CSF/serum ratio in the study group was 2.38% (interquartile range [IQR] 1.14-3.97) and 1.09% (IQR 0.95-1.45) in the control group. ROC curve analysis of PChE CSF/serum ratio resulted in an area under the curve (AUC) value of 0.76 (95% confidence interval [CI] 0.63-0.88) and a cut-off of 1.09. Twenty five of 29 patients with elevated PChE CSF/serum ratio had a tumor, corresponding to a sensitivity of 83% and a specificity of 53%. ----- CONCLUSION: PChE CSF/serum ratio may be used as a test or biomarker with good sensitivity for solid CNS tumors in children.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 54, no. 5, pp. 429-435
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2013.54.429
URN:NBNurn:nbn:hr:105:396089
Publication2013-10-28
Document URLhttps://doi.org/10.3325/cmj.2013.54.429
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:08:02