prikaz prve stranice dokumenta Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men
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Scientific paper - Original scientific paper
Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men
Croatian Medical Journal, 55 (2014), 1; 38-44. https://doi.org/10.3325/cmj.2014.55.38
Golubić, Karlo; Šmalcelj, Anton; Sertić, Jadranka; Juričić, Ljiljana

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Golubić, K., Šmalcelj, A., Sertić, J. & Juričić, Lj. (2014). Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men. Croatian Medical Journal, 55. (1), 38-44. doi: 10.3325/cmj.2014.55.38

Golubić, Karlo, et al. "Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men." Croatian Medical Journal, vol. 55, no. 1, 2014, pp. 38-44. https://doi.org/10.3325/cmj.2014.55.38

Golubić, Karlo, Anton Šmalcelj, Jadranka Sertić and Ljiljana Juričić. "Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men." Croatian Medical Journal 55, no. 1 (2014): 38-44. https://doi.org/10.3325/cmj.2014.55.38

Golubić, K., et al. (2014) 'Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men', Croatian Medical Journal, 55(1), pp. 38-44. doi: 10.3325/cmj.2014.55.38

Golubić K, Šmalcelj A, Sertić J, Juričić Lj. Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men. Croatian Medical Journal [Internet]. 2014 February [cited 2024 May 08];55(1):38-44. doi: 10.3325/cmj.2014.55.38

K. Golubić, A. Šmalcelj, J. Sertić and Lj. Juričić, "Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men", Croatian Medical Journal, vol. 55, no. 1, pp. 38-44, February 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:167332. [Accessed: 08 May 2024]

Metadata
Title (english)Estrogen receptor 1 gene (TA)n polymorphism is associated with lone atrial fibrillation in men
AuthorKarlo Golubić
AuthorAnton Šmalcelj
AuthorJadranka Sertić
AuthorLjiljana Juričić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To determine the association between the number of thymine-adenine (TA)n dinucleotide repeats in the promoter region of the gene coding for the estrogen receptor alpha (ESR1) and the prevalence of lone atrial fibrillation (AF) in men. ----- METHODS: We conducted a case-control study involving 89 men with lone AF and 166 healthy male controls. The ESR1 genotype was established by polymerase chain reaction and capillary electrophoresis. To assess the association of ESR1 genotype with AF, logistic regression models were built with AF as outcome. ----- RESULTS: Men with lone AF had significantly greater number of (TA)n repeats of single alleles than controls (mean ± standard deviation, 19.2 ± 4.2 vs 18 ± 4.3, P = 0.010). After adjustment for other factors, a unit-increase in (TA)n repeat number was associated with a significantly greater likelihood of AF (odds ratio 1.069; 95% confidence interval 1.024-1.116, P=0.002). ----- CONCLUSIONS: Our results indicate that a greater number of (TA)n repeats in the promoter region of ESR1 is associated with a significantly increased likelihood of lone atrial fibrillation in men.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 55, no. 1, pp. 38-44
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2014.55.38
URN:NBNurn:nbn:hr:105:167332
Publication2014-02
Document URLhttps://doi.org/10.3325/cmj.2014.55.38
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:09:20