prikaz prve stranice dokumenta Albendazolesulphoxide concentrations in plasma and hydatid cyst and prediction of parasitological and clinical outcomes in patients with liver hydatidosis caused by Echinococcus granulosus
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Scientific paper - Original scientific paper
Albendazolesulphoxide concentrations in plasma and hydatid cyst and prediction of parasitological and clinical outcomes in patients with liver hydatidosis caused by Echinococcus granulosus
Croatian Medical Journal, 55 (2014), 2; 146-155. https://doi.org/10.3325/cmj.2014.55.146
Skuhala, Tomislava; Trkulja, Vladimir; Runje, Mislav; Vukelić, Dalibor; Desnica, Boško

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Skuhala, T., Trkulja, V., Runje, M., Vukelić, D. & Desnica, B. (2014). Albendazolesulphoxide concentrations in plasma and hydatid cyst and prediction of parasitological and clinical outcomes in patients with liver hydatidosis caused by Echinococcus granulosus. Croatian Medical Journal, 55. (2), 146-155. doi: 10.3325/cmj.2014.55.146

Skuhala, Tomislava, et al. "Albendazolesulphoxide concentrations in plasma and hydatid cyst and prediction of parasitological and clinical outcomes in patients with liver hydatidosis caused by Echinococcus granulosus." Croatian Medical Journal, vol. 55, no. 2, 2014, pp. 146-155. https://doi.org/10.3325/cmj.2014.55.146

Skuhala, Tomislava, Vladimir Trkulja, Mislav Runje, Dalibor Vukelić and Boško Desnica. "Albendazolesulphoxide concentrations in plasma and hydatid cyst and prediction of parasitological and clinical outcomes in patients with liver hydatidosis caused by Echinococcus granulosus." Croatian Medical Journal 55, no. 2 (2014): 146-155. https://doi.org/10.3325/cmj.2014.55.146

Skuhala, T., et al. (2014) 'Albendazolesulphoxide concentrations in plasma and hydatid cyst and prediction of parasitological and clinical outcomes in patients with liver hydatidosis caused by Echinococcus granulosus', Croatian Medical Journal, 55(2), pp. 146-155. doi: 10.3325/cmj.2014.55.146

Skuhala T, Trkulja V, Runje M, Vukelić D, Desnica B. Albendazolesulphoxide concentrations in plasma and hydatid cyst and prediction of parasitological and clinical outcomes in patients with liver hydatidosis caused by Echinococcus granulosus. Croatian Medical Journal [Internet]. 2014 April [cited 2024 November 23];55(2):146-155. doi: 10.3325/cmj.2014.55.146

T. Skuhala, V. Trkulja, M. Runje, D. Vukelić and B. Desnica, "Albendazolesulphoxide concentrations in plasma and hydatid cyst and prediction of parasitological and clinical outcomes in patients with liver hydatidosis caused by Echinococcus granulosus", Croatian Medical Journal, vol. 55, no. 2, pp. 146-155, April 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:418447. [Accessed: 23 November 2024]

Metadata
Title (english)Albendazolesulphoxide concentrations in plasma and hydatid cyst and prediction of parasitological and clinical outcomes in patients with liver hydatidosis caused by Echinococcus granulosus
AuthorTomislava Skuhala
AuthorVladimir Trkulja
AuthorMislav Runje
AuthorDalibor Vukelić
AuthorBoško Desnica
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: To investigate the relationship between plasma and cyst concentrations of albendazolesulphoxide (ASO) and their effects on parasitological findings and disease recurrence in patients with liver hydatidosis. ----- METHODS: The study was conducted at the University Hospital for Infectious Diseases Dr. Fran Mihaljević, Zagreb, Croatia, between August 2006 and January 2011. Consecutive patients (N=48, age 6-77 years) were treated with albendazole (3×5 mg/kg/d) over 28 days before surgical cyst removal (n=34) or percutaneous evacuation (PAIR) (n=14). Plasma ASO was determined on days 10 and 28 of treatment and cyst concentrations at surgery/PAIR. ----- RESULTS: Disease recurred in 3 surgically treated patients. Variability of ASO concentrations was substantial. Plasma concentrations on day 10 were higher than on day 28 (geometric means ratio [GMR] 2.00; 95%CI 1.38-2.91, P<0.001) and higher than cyst concentrations at the time of treatment (GMR=1.58, 1.01-2.34, P=0.045). Higher cyst (but not plasma) concentrations were independently associated with lower odds of protoscolex motility (OR=0.23, 0.01-0.70, P<0.001) and higher odds of protoscolex destruction (OR=1.17, 1.04-1.46, P<0.001). With adjustment for age and protoscolex motility, higher day 10 plasma concentrations (but not cyst concentrations) were associated with lower odds of disease recurrence (OR=0.49, 0.09-0.97, P=0.035). Plasma concentrations did not predict cyst concentrations. ----- CONCLUSION: Viability of protoscolices progressively decreased with increasing ASO concentrations in the cyst. Data strongly suggested that higher plasma concentrations reduced the risk of disease recurrence.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 55, no. 2, pp. 146-155
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2014.55.146
URN:NBNurn:nbn:hr:105:418447
Publication2014-04
Document URLhttps://doi.org/10.3325/cmj.2014.55.146
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:08:52