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Scientific paper - Original scientific paper
Update on the core and developing cerebrospinal fluid biomarkers for Alzheimer disease
Croatian Medical Journal, 55 (2014), 4; 347-365. https://doi.org/10.3325/cmj.2014.55.347
Babić, Mirjana; Švob Štrac, Dubravka; Mück-Šeler, Dorotea; Pivac, Nela; Stanić, Gabrijela; Hof, Patrick R.; Šimić, Goran

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Babić, M., Švob Štrac, D., Mück Šeler, D., Pivac, N., Stanić, G., Hof, P. R. & Šimić, G. (2014). Update on the core and developing cerebrospinal fluid biomarkers for Alzheimer disease. Croatian Medical Journal, 55. (4), 347-365. doi: 10.3325/cmj.2014.55.347

Babić, Mirjana, et al. "Update on the core and developing cerebrospinal fluid biomarkers for Alzheimer disease." Croatian Medical Journal, vol. 55, no. 4, 2014, pp. 347-365. https://doi.org/10.3325/cmj.2014.55.347

Babić, Mirjana, Dubravka Švob Štrac, Dorotea Mück Šeler, Nela Pivac, Gabrijela Stanić, Patrick R. Hof and Goran Šimić. "Update on the core and developing cerebrospinal fluid biomarkers for Alzheimer disease." Croatian Medical Journal 55, no. 4 (2014): 347-365. https://doi.org/10.3325/cmj.2014.55.347

Babić, M., et al. (2014) 'Update on the core and developing cerebrospinal fluid biomarkers for Alzheimer disease', Croatian Medical Journal, 55(4), pp. 347-365. doi: 10.3325/cmj.2014.55.347

Babić M, Švob Štrac D, Mück Šeler D, Pivac N, Stanić G, Hof PR, and sur.. Update on the core and developing cerebrospinal fluid biomarkers for Alzheimer disease. Croatian Medical Journal [Internet]. 2014 August 28 [cited 2024 May 19];55(4):347-365. doi: 10.3325/cmj.2014.55.347

M. Babić, et al., "Update on the core and developing cerebrospinal fluid biomarkers for Alzheimer disease", Croatian Medical Journal, vol. 55, no. 4, pp. 347-365, August 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:071815. [Accessed: 19 May 2024]

Metadata
Title (english)Update on the core and developing cerebrospinal fluid biomarkers for Alzheimer disease
AuthorMirjana Babić
AuthorDubravka Švob Štrac
AuthorDorotea Mück-Šeler
AuthorNela Pivac
AuthorGabrijela Stanić
AuthorPatrick R. Hof
AuthorGoran Šimić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Alzheimer disease (AD) is a complex neurodegenerative disorder, whose prevalence will dramatically rise by 2050. Despite numerous clinical trials investigating this disease, there is still no effective treatment. Many trials showed negative or inconclusive results, possibly because they recruited only patients with severe disease, who had not undergone disease-modifying therapies in preclinical stages of AD before severe degeneration occurred. Detection of AD in asymptomatic at risk individuals (and a few presymptomatic individuals who carry an autosomal dominant monogenic AD mutation) remains impractical in many of clinical situations and is possible only with reliable biomarkers. In addition to early diagnosis of AD, biomarkers should serve for monitoring disease progression and response to therapy. To date, the most promising biomarkers are cerebrospinal fluid (CSF) and neuroimaging biomarkers. Core CSF biomarkers (amyloid β1-42, total tau, and phosphorylated tau) showed a high diagnostic accuracy but were still unreliable for preclinical detection of AD. Hence, there is an urgent need for detection and validation of novel CSF biomarkers that would enable early diagnosis of AD in asymptomatic individuals. This article reviews recent research advances on biomarkers for AD, focusing mainly on the CSF biomarkers. In addition to core CSF biomarkers, the potential usefulness of novel CSF biomarkers is discussed.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 55, no. 4, pp. 347-365
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2014.55.347
URN:NBNurn:nbn:hr:105:071815
Publication2014-08-28
Document URLhttps://doi.org/10.3325/cmj.2014.55.347
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:10:20