prikaz prve stranice dokumenta Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?
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Scientific paper - Original scientific paper
Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?
Croatian Medical Journal, 55 (2014), 4; 317-327. https://doi.org/10.3325/cmj.2014.55.317
Orešković, Darko; Klarica, Marijan

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Orešković, D. & Klarica, M. (2014). Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?. Croatian Medical Journal, 55. (4), 317-327. doi: 10.3325/cmj.2014.55.317

Orešković, Darko and Marijan Klarica. "Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?." Croatian Medical Journal, vol. 55, no. 4, 2014, pp. 317-327. https://doi.org/10.3325/cmj.2014.55.317

Orešković, Darko and Marijan Klarica. "Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?." Croatian Medical Journal 55, no. 4 (2014): 317-327. https://doi.org/10.3325/cmj.2014.55.317

Orešković, D. and Klarica, M. (2014) 'Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?', Croatian Medical Journal, 55(4), pp. 317-327. doi: 10.3325/cmj.2014.55.317

Orešković D, Klarica M. Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?. Croatian Medical Journal [Internet]. 2014 August 28 [cited 2024 May 02];55(4):317-327. doi: 10.3325/cmj.2014.55.317

D. Orešković and M. Klarica, "Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?", Croatian Medical Journal, vol. 55, no. 4, pp. 317-327, August 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:814611. [Accessed: 02 May 2024]

Metadata
Title (english)Measurement of cerebrospinal fluid formation and absorption by ventriculo-cisternal perfusion: what is really measured?
AuthorDarko Orešković
AuthorMarijan Klarica
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The generally accepted hypothesis on cerebrospinal fluid (CSF) hydrodynamics suggests that CSF is actively formed mainly by the choroid plexuses, circulates unidirectionally along the brain ventricles and subarachnoid space, and is passively absorbed mainly into the dural venous sinuses. CSF formation rate (Vf) has been extensively studied using the ventriculo-cisternal perfusion technique and the results have been used as the key evidence confirming the mentioned hypothesis. This technique and the equation for Vf calculation are based on the assumption that the dilution of the indicator substance is a consequence of the newly formed CSF, ie, that a higher CSF formation rate will result in a higher degree of dilution. However, it has been experimentally shown that the indicator substance dilution inside the CSF system does not occur because of a "newly formed" CSF, but as consequence of a number of other factors (departure of substances into the surrounding tissue, flowing around the collecting cannula into the cortical and spinal subarachnoid space, departure into the contralateral ventricle, etc). This technique allows "calculation" of the CSF formation even in dead animals, in an in vitro model, and in any other part of the CSF system outside the ventricles that is being perfused. Therefore, this method is indirect and any dilution of the indicator substance in the perfusate caused by other reasons would result in questionable and often contradictory conclusions regarding CSF formation rates.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 55, no. 4, pp. 317-327
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2014.55.317
URN:NBNurn:nbn:hr:105:814611
Publication2014-08-28
Document URLhttps://doi.org/10.3325/cmj.2014.55.317
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:09:59