prikaz prve stranice dokumenta Volumetric analysis of cerebrospinal fluid and brain parenchyma in a patient with hydranencephaly and macrocephaly - case report
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Scientific paper - Case study
Volumetric analysis of cerebrospinal fluid and brain parenchyma in a patient with hydranencephaly and macrocephaly - case report
Croatian Medical Journal, 55 (2014), 4; 388-393. https://doi.org/10.3325/cmj.2014.55.388
Radoš, Milan; Klarica, Marijan; Mučić-Pucić, Branka; Nikić, Ines; Raguž, Marina; Galkowski, Valentina; Mandić, Dora; Orešković, Darko

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Radoš, M., Klarica, M., Mučić Pucić, B., Nikić, I., Raguž, M., Galkowski, V. ... Orešković, D. (2014). Volumetric analysis of cerebrospinal fluid and brain parenchyma in a patient with hydranencephaly and macrocephaly - case report. Croatian Medical Journal, 55. (4), 388-393. doi: 10.3325/cmj.2014.55.388

Radoš, Milan, et al. "Volumetric analysis of cerebrospinal fluid and brain parenchyma in a patient with hydranencephaly and macrocephaly - case report." Croatian Medical Journal, vol. 55, no. 4, 2014, pp. 388-393. https://doi.org/10.3325/cmj.2014.55.388

Radoš, Milan, Marijan Klarica, Branka Mučić Pucić, Ines Nikić, Marina Raguž, Valentina Galkowski, Dora Mandić and Darko Orešković. "Volumetric analysis of cerebrospinal fluid and brain parenchyma in a patient with hydranencephaly and macrocephaly - case report." Croatian Medical Journal 55, no. 4 (2014): 388-393. https://doi.org/10.3325/cmj.2014.55.388

Radoš, M., et al. (2014) 'Volumetric analysis of cerebrospinal fluid and brain parenchyma in a patient with hydranencephaly and macrocephaly - case report', Croatian Medical Journal, 55(4), pp. 388-393. doi: 10.3325/cmj.2014.55.388

Radoš M, Klarica M, Mučić Pucić B, Nikić I, Raguž M, Galkowski V, and sur.. Volumetric analysis of cerebrospinal fluid and brain parenchyma in a patient with hydranencephaly and macrocephaly - case report. Croatian Medical Journal [Internet]. 2014 August 28 [cited 2024 May 02];55(4):388-393. doi: 10.3325/cmj.2014.55.388

M. Radoš, et al., "Volumetric analysis of cerebrospinal fluid and brain parenchyma in a patient with hydranencephaly and macrocephaly - case report", Croatian Medical Journal, vol. 55, no. 4, pp. 388-393, August 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:826519. [Accessed: 02 May 2024]

Metadata
Title (english)Volumetric analysis of cerebrospinal fluid and brain parenchyma in a patient with hydranencephaly and macrocephaly - case report
AuthorMilan Radoš
AuthorMarijan Klarica
AuthorBranka Mučić-Pucić
AuthorInes Nikić
AuthorMarina Raguž
AuthorValentina Galkowski
AuthorDora Mandić
AuthorDarko Orešković
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The aim of this study was to perform for the first time the intracranial volumetric analysis of cerebrospinal fluid (CSF) and brain parenchyma in the supratentorial and infratentorial space in a 30-year-old female patient with hydranencephaly and macrocephaly. A head scan performed using a 3T magnetic resonance was followed by manual segmentation of the brain parenchyma and CSF on T2 coronal brain sections. The volume of CSF and brain parenchyma was measured separately for the supratentorial and infratentorial space. The total volume of the intracranial space was 3645.5 cm(3). In the supratentorial space, the volume of CSF was 3375.2 cm(3) and the volume of brain parenchyma was 80.3 cm(3). In the infratentorial space, the volume of CSF was 101.3 cm(3) and the volume of the brain parenchyma was 88.7 cm(3). In the supratentorial space, there was severe malacia of almost all brain parenchyma with no visible remnants of the choroid plexuses. Infratentorial structures of the brainstem and cerebellum were hypoplastic but completely developed. Since our patient had no choroid plexuses in the supratentorial space and no obstruction between dural sinuses and CSF, development of hydrocephalus and macrocephaly cannot be explained by the classic hypothesis of CSF physiology with secretion, unidirectional circulation, and absorption as its basic postulates. However, the origin and turnover of the enormous amount of intracranial CSF volume, at least 10-fold larger than normal, and the mechanisms of macroencephaly development could be elucidated by the new hypothesis of CSF physiology recently published by our research team.
Keywords (english)
Languageenglish
Publication typeScientific paper - Case study
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 55, no. 4, pp. 388-393
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2014.55.388
URN:NBNurn:nbn:hr:105:826519
Publication2014-08-28
Document URLhttps://doi.org/10.3325/cmj.2014.55.388
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:10:31