prikaz prve stranice dokumenta Total and LDL cholesterol are associated with glomerular filtration rate in normoalbuminuric type 1 diabetic patients
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Scientific paper - Original scientific paper
Total and LDL cholesterol are associated with glomerular filtration rate in normoalbuminuric type 1 diabetic patients
Collegium Antropologicum, 37 (2013), 3; 771-776. urn:nbn:hr:105:187672
Bulum, Tomislav; Kolarić, Branko; Prkačin, Ingrid; Duvnjak, Lea

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Bulum, T., Kolarić, B., Prkačin, I. & Duvnjak, L. (2013). Total and LDL cholesterol are associated with glomerular filtration rate in normoalbuminuric type 1 diabetic patients . Collegium Antropologicum, 37. (3), 771-776. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:187672

Bulum, Tomislav, et al. "Total and LDL cholesterol are associated with glomerular filtration rate in normoalbuminuric type 1 diabetic patients ." Collegium Antropologicum, vol. 37, no. 3, 2013, pp. 771-776. https://urn.nsk.hr/urn:nbn:hr:105:187672

Bulum, Tomislav, Branko Kolarić, Ingrid Prkačin and Lea Duvnjak. "Total and LDL cholesterol are associated with glomerular filtration rate in normoalbuminuric type 1 diabetic patients ." Collegium Antropologicum 37, no. 3 (2013): 771-776. https://urn.nsk.hr/urn:nbn:hr:105:187672

Bulum, T., et al. (2013) 'Total and LDL cholesterol are associated with glomerular filtration rate in normoalbuminuric type 1 diabetic patients ', Collegium Antropologicum, 37(3), pp. 771-776. Available at: https://urn.nsk.hr/urn:nbn:hr:105:187672 (Accessed 26 November 2024)

Bulum T, Kolarić B, Prkačin I, Duvnjak L. Total and LDL cholesterol are associated with glomerular filtration rate in normoalbuminuric type 1 diabetic patients . Collegium Antropologicum [Internet]. 2013 September [cited 2024 November 26];37(3):771-776. Available at: https://urn.nsk.hr/urn:nbn:hr:105:187672

T. Bulum, B. Kolarić, I. Prkačin and L. Duvnjak, "Total and LDL cholesterol are associated with glomerular filtration rate in normoalbuminuric type 1 diabetic patients ", Collegium Antropologicum, vol. 37, no. 3, pp. 771-776, September 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:187672. [Accessed: 26 November 2024]

Metadata
Title (english)Total and LDL cholesterol are associated with glomerular filtration rate in normoalbuminuric type 1 diabetic patients
Title (croatian)Ukupni i LDL kolesterol su povezani s glomerularnom flitracijom u normoalbuminuričnih bolesnika sa tipom 1 šećerne bolesti
AuthorTomislav Bulum
AuthorBranko Kolarić
AuthorIngrid Prkačin
AuthorLea Duvnjak
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Studies have generally suggested a positive association between dyslipidemia and chronic kidney disease, but sparse data are available on the relation of lipids and glomerular filtration rate in patients with normal renal function. We investigated the associations of serum lipids, including total, LDL, HDL, VLDL cholesterol, and triglyceride levels with estimated glomerular filtration rate (eGFR) in type 1 diabetic patients. Study included 313 normoalbuminuric type 1 diabetic patients with normal or mild decrease (eGFR > 60 mL/min per 1.73 m2) renal function and before any interventions with statins, ACE inhibitors or angiotensin II receptor blockers. eGFR was significantly associated with total, LDL, and HDL cholesterol (r = -0.21, -0.18, and -0.17, respectively, for all p < 0.05). Stratifying serum lipids for degree of eGFR, levels of total, LDL, and HDL cholesterol were inversely related to eGFR, but trends were significant only for total (5.1 vs 5.0 and 4.6 mmol/L) and LDL cholesterol (2.9 vs 2.8 and 2.4 mmol/L). We have detected an association between eGFR and lipid abnormalities in type 1 diabetes in early stages. The study was conducted in patients with no therapeutic intervention. This may suggest that lipid abnormalities may play a role in the pathogenesis of renal impairment in type 1 diabetic patients.
Abstract (croatian)
Mnoga istraživanja su potvrdila značaj dislipidemije u kroničnoj bubrežnoj bolesti, ali malo toga je poznato o utjecaju serumskih lipida na glomerularnu filtraciju u osoba sa normalnom bubrežnom funkcijom. Istraživali smo povezanost serumskih lipida (ukupnog, LDL, HDL, HDL2, HDL3, VLDL kolesterola i triglicerida) te glomerularne filtracije (GF) u bolesnika sa tipom 1 šećerne bolesti. Istraživanje je obuhvatilo 313 normoalbuminuričnih bolesnika sa tipom 1 šećerne bolesti s urednom ili blago sniženom bubrežnom funkcijom (GF >60 mL/min/ 1.73 m2) i prije terapije statinima, ACE-inhibitorima ili blokatorima angiotenzinskih receptora. GF procijenjena CKD-EPI iMDRD formulom bila je statistički značajno povezana s ukupnim, LDL, HDL, HDL2, i HDL3 kolesterolom (r= –0.21, –0.18, –0.17, –0.21, i –0.14, za sve p<0.05). Nakon podjele bolesnika prema stupnju GF, razina ukupnog, LDL, HDL i HDL2 kolesterola je bila u negativnoj povezanosti s razinom GF, ali je statistički značajna povezanost dokazana samo za razinu ukupnog (5.1 prema 5.0 i 4.6 mmol/L) i LDL kolesterola (2.9 prema 2.8 i 2.4 mmol/L). Rezultati istraživanja ukazuju da je lipidni poremećaj prisutan već u stanju normalne bubrežne funkcije u normoalbuminuričnih bolesnika sa tipom 1 šećerne bolesti i da je viša razina ukupnog i LDL kolesterola povezana s pogoršanjem GF. Prospektivne studije će pokazati da li navedeni lipidni poremećaji doprinose progresiji bubrežne bolesti u bolesnika sa tipom 1 šećerne bolesti.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 37, no. 3, pp. 771-776
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:187672
Publication2013-09
Document URLhttps://hrcak.srce.hr/118216
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:13:04