prikaz prve stranice dokumenta Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway
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Scientific paper - Original scientific paper
Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway
Acta Neurobiologiae Experimentalis, 74 (2014), 3; 257-265. urn:nbn:hr:105:900226
Bačić Baronica, Koraljka; Mlinac, Kristina; Petlevski, Roberta; Ozretić, David; Vladić, Anton; Kalanj-Bognar, Svjetlana; Žuntar, Irena

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Bačić Baronica, K., Mlinac, K., Petlevski, R., Ozretić, D., Vladić, A., Kalanj Bognar, S. & Žuntar, I. (2014). Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway. Acta Neurobiologiae Experimentalis, 74. (3), 257-265. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:900226

Bačić Baronica, Koraljka, et al. "Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway." Acta Neurobiologiae Experimentalis, vol. 74, no. 3, 2014, pp. 257-265. https://urn.nsk.hr/urn:nbn:hr:105:900226

Bačić Baronica, Koraljka, Kristina Mlinac, Roberta Petlevski, David Ozretić, Anton Vladić, Svjetlana Kalanj Bognar and Irena Žuntar. "Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway." Acta Neurobiologiae Experimentalis 74, no. 3 (2014): 257-265. https://urn.nsk.hr/urn:nbn:hr:105:900226

Bačić Baronica, K., et al. (2014) 'Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway', Acta Neurobiologiae Experimentalis, 74(3), pp. 257-265. Available at: https://urn.nsk.hr/urn:nbn:hr:105:900226 (Accessed 12 May 2024)

Bačić Baronica K, Mlinac K, Petlevski R, Ozretić D, Vladić A, Kalanj Bognar S, and sur.. Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway. Acta Neurobiologiae Experimentalis [Internet]. 2014 [cited 2024 May 12];74(3):257-265. Available at: https://urn.nsk.hr/urn:nbn:hr:105:900226

K. Bačić Baronica, et al., "Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway", Acta Neurobiologiae Experimentalis, vol. 74, no. 3, pp. 257-265, 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:900226. [Accessed: 12 May 2024]

Metadata
Title (english)Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway
AuthorKoraljka Bačić Baronica
AuthorKristina Mlinac
AuthorRoberta Petlevski
AuthorDavid Ozretić
AuthorAnton Vladić
AuthorSvjetlana Kalanj-Bognar
AuthorIrena Žuntar
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The impact of glutathione S-transferases (GSTs) detoxification pathway on complex pathogenesis and heterogeneity of clinical findings in multiple sclerosis (MS), particularly the exact correlation between indicators of clinical severity and different GST genotypes, has not yet been fully elucidated. The aim of the study was to assess the relationship between disability level in multiple sclerosis (estimated by Kurtzke Expanded Disability Status Scale), disease progression (estimated by Multiple Sclerosis Severity Score), the level of brain atrophy and lesion load (determined by MRI) and detoxification status (analyzing glutathione S-transferase P1, GSTP1, genotype profile), in a group of 58 MS patients and 68 age/gendermatched controls. The results present the first evidence on significantly higher frequency of GSTP1 C341T polymorphism (C-T transition) in healthy subjects compared to MS patients, suggesting it may act as a moderating factor in developing MS clinical phenotype. Gender-dependent distribution of the C341T polymorphism was found in both MS patients and controls, with higher frequency of C-T transition in females. In addition, preliminary data showed higher proportion of male MS patients with higher median MSSS scores, as well as lower brain atrophy level and lesion load in MS patients carrying the C341T mutation. Observed gender difference in distribution of the C341T polymorphism in MS patients, as well as in disease progression, suggests that GSTP1 detoxification pathway occurs in a gender-dependent manner and could therefore add to clinical severity in male MS patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa Neurobiologiae Experimentalis
Numberingvol. 74, no. 3, pp. 257-265
p-ISSN1689-0035
URN:NBNurn:nbn:hr:105:900226
Publication2014
Document URLhttp://www.ane.pl/linkout.php?pii=7425
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:14:26