prikaz prve stranice dokumenta No change in N-acetyl aspartate in first episode of moderate depression after antidepressant treatment: (1)H magnetic spectroscopy study of left amygdala and left dorsolateral prefrontal cortex
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Scientific paper - Original scientific paper
No change in N-acetyl aspartate in first episode of moderate depression after antidepressant treatment: (1)H magnetic spectroscopy study of left amygdala and left dorsolateral prefrontal cortex
Neuropsychiatric Disease and Treatment, 10 (2014); 1753-1762. https://doi.org/10.2147/NDT.S64702
Bajs Janović, Maja; Kalember, Petra; Janović, Špiro; Hrabač, Pero; Folnegović Grošić, Petra; Grošić, Vladimir; Radoš, Marko; Henigsberg, Neven

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Bajs Janović, M., Kalember, P., Janović, Š., Hrabač, P., Folnegović Grošić, P., Grošić, V. ... Henigsberg, N. (2014). No change in N-acetyl aspartate in first episode of moderate depression after antidepressant treatment: (1)H magnetic spectroscopy study of left amygdala and left dorsolateral prefrontal cortex. Neuropsychiatric Disease and Treatment, 10., 1753-1762. doi: 10.2147/NDT.S64702

Bajs Janović, Maja, et al. "No change in N-acetyl aspartate in first episode of moderate depression after antidepressant treatment: (1)H magnetic spectroscopy study of left amygdala and left dorsolateral prefrontal cortex." Neuropsychiatric Disease and Treatment, vol. 10, 2014, pp. 1753-1762. https://doi.org/10.2147/NDT.S64702

Bajs Janović, Maja, Petra Kalember, Špiro Janović, Pero Hrabač, Petra Folnegović Grošić, Vladimir Grošić, Marko Radoš and Neven Henigsberg. "No change in N-acetyl aspartate in first episode of moderate depression after antidepressant treatment: (1)H magnetic spectroscopy study of left amygdala and left dorsolateral prefrontal cortex." Neuropsychiatric Disease and Treatment 10 (2014): 1753-1762. https://doi.org/10.2147/NDT.S64702

Bajs Janović, M., et al. (2014) 'No change in N-acetyl aspartate in first episode of moderate depression after antidepressant treatment: (1)H magnetic spectroscopy study of left amygdala and left dorsolateral prefrontal cortex', Neuropsychiatric Disease and Treatment, 10, pp. 1753-1762. doi: 10.2147/NDT.S64702

Bajs Janović M, Kalember P, Janović Š, Hrabač P, Folnegović Grošić P, Grošić V, and sur.. No change in N-acetyl aspartate in first episode of moderate depression after antidepressant treatment: (1)H magnetic spectroscopy study of left amygdala and left dorsolateral prefrontal cortex. Neuropsychiatric Disease and Treatment [Internet]. 2014 September 17 [cited 2024 November 30];10:1753-1762. doi: 10.2147/NDT.S64702

M. Bajs Janović, et al., "No change in N-acetyl aspartate in first episode of moderate depression after antidepressant treatment: (1)H magnetic spectroscopy study of left amygdala and left dorsolateral prefrontal cortex", Neuropsychiatric Disease and Treatment, vol. 10, pp. 1753-1762, September 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:918098. [Accessed: 30 November 2024]

Metadata
Title (english)No change in N-acetyl aspartate in first episode of moderate depression after antidepressant treatment: (1)H magnetic spectroscopy study of left amygdala and left dorsolateral prefrontal cortex
AuthorMaja Bajs Janović
AuthorPetra Kalember
AuthorŠpiro Janović
AuthorPero Hrabač
AuthorPetra Folnegović Grošić
AuthorVladimir Grošić
AuthorMarko Radoš
AuthorNeven Henigsberg
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: The role of brain metabolites as biological correlates of the intensity, symptoms, and course of major depression has not been determined. It has also been inconclusive whether the change in brain metabolites, measured with proton magnetic spectroscopy, could be correlated with the treatment outcome. ----- METHODS: Proton magnetic spectroscopy was performed in 29 participants with a first episode of moderate depression occurring in the left dorsolateral prefrontal cortex and left amygdala at baseline and after 8 weeks of antidepressant treatment with escitalopram. The Montgomery-Asberg Depression Rating Scale, the Hamilton Rating Scale for Depression, and the Beck Depression Inventory were used to assess the intensity of depression at baseline and at the endpoint of the study. At endpoint, the participants were identified as responders (n=17) or nonresponders (n=12) to the antidepressant therapy. ----- RESULTS: There was no significant change in the N-acetyl aspartate/creatine ratio (NAA/Cr) after treatment with antidepressant medication. The baseline and endpoint NAA/Cr ratios were not significantly different between the responder and nonresponder groups. The correlation between NAA/Cr and changes in the scores of clinical scales were not significant in either group. ----- CONCLUSION: This study could not confirm any significant changes in NAA after antidepressant treatment in the first episode of moderate depression, or in regard to therapy response in the left dorsolateral prefrontal cortex or left amygdala. Further research is necessary to conclude whether NAA alterations in the first episode of depression could possibly be different from chronic or late-onset depression, and whether NAA alterations in stress-induced (reactive) depression are different from endogenous depression. The potential role of NAA as a biomarker of a treatment effect has yet to be established.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleNeuropsychiatric Disease and Treatment
Numberingvol. 10, pp. 1753-1762
p-ISSN1178-2021
DOIhttps://doi.org/10.2147/NDT.S64702
URN:NBNurn:nbn:hr:105:918098
Publication2014-09-17
Document URLhttps://doi.org/10.2147/NDT.S64702
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:14:45