prikaz prve stranice dokumenta Interaction of genetic risk factors confers increased risk for metabolic syndrome: the role of peroxisome proliferator-activated receptor γ
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Scientific paper - Original scientific paper
Interaction of genetic risk factors confers increased risk for metabolic syndrome: the role of peroxisome proliferator-activated receptor γ
Genetic Testing and Molecular Biomarkers, 18 (2014), 1; 32-40. https://doi.org/10.1089/gtmb.2013.0344
Božina, Tamara; Sertić, Jadranka; Lovrić, Jasna; Jelaković, Bojan; Šimić, Iveta; Reiner, Željko

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Božina, T., Sertić, J., Lovrić, J., Jelaković, B., Šimić, I. & Reiner, Ž. (2014). Interaction of genetic risk factors confers increased risk for metabolic syndrome: the role of peroxisome proliferator-activated receptor γ. Genetic Testing and Molecular Biomarkers, 18. (1), 32-40. doi: 10.1089/gtmb.2013.0344

Božina, Tamara, et al. "Interaction of genetic risk factors confers increased risk for metabolic syndrome: the role of peroxisome proliferator-activated receptor γ." Genetic Testing and Molecular Biomarkers, vol. 18, no. 1, 2014, pp. 32-40. https://doi.org/10.1089/gtmb.2013.0344

Božina, Tamara, Jadranka Sertić, Jasna Lovrić, Bojan Jelaković, Iveta Šimić and Željko Reiner. "Interaction of genetic risk factors confers increased risk for metabolic syndrome: the role of peroxisome proliferator-activated receptor γ." Genetic Testing and Molecular Biomarkers 18, no. 1 (2014): 32-40. https://doi.org/10.1089/gtmb.2013.0344

Božina, T., et al. (2014) 'Interaction of genetic risk factors confers increased risk for metabolic syndrome: the role of peroxisome proliferator-activated receptor γ', Genetic Testing and Molecular Biomarkers, 18(1), pp. 32-40. doi: 10.1089/gtmb.2013.0344

Božina T, Sertić J, Lovrić J, Jelaković B, Šimić I, Reiner Ž. Interaction of genetic risk factors confers increased risk for metabolic syndrome: the role of peroxisome proliferator-activated receptor γ. Genetic Testing and Molecular Biomarkers [Internet]. 2014 January [cited 2024 December 24];18(1):32-40. doi: 10.1089/gtmb.2013.0344

T. Božina, J. Sertić, J. Lovrić, B. Jelaković, I. Šimić and Ž. Reiner, "Interaction of genetic risk factors confers increased risk for metabolic syndrome: the role of peroxisome proliferator-activated receptor γ", Genetic Testing and Molecular Biomarkers, vol. 18, no. 1, pp. 32-40, January 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:478688. [Accessed: 24 December 2024]

Metadata
Title (english)Interaction of genetic risk factors confers increased risk for metabolic syndrome: the role of peroxisome proliferator-activated receptor γ
AuthorTamara Božina
AuthorJadranka Sertić
AuthorJasna Lovrić
AuthorBojan Jelaković
AuthorIveta Šimić
AuthorŽeljko Reiner
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: The aim of the study was to estimate the influence of interactions between peroxisome proliferator-activated receptor γ (PPARγ) and target genes lipoprotein lipase (LPL), interleukin 6 (IL6), angiotensin converting enzyme (ACE), and angiotensin II type 1 receptor (AT1R) on metabolic syndrome (MetSy) and its traits. ----- METHODS: The study included 527 participants (263 with MetSy and 264 controls). Genotyping of PPARγ Pro12Ala, LPL PvuII (-/+), IL6 -174G>C, ACE I/D and AT1R 1166A>C was performed using polymerase chain reaction-restriction fragment length polymorphism-based methods. ----- RESULTS: Interaction between PPARγ Pro12Ala and LPL Pvu(-/+) improved prediction of MetSy over and above prediction based on a model containing no interactions (χ(2)=7.22; df=1; p=0.007). In the group of participants with PPARγ Pro12Ala or Ala12Ala genotypes, those with the LPL Pvu (-/+) or (+/+) genotype had greater odds for MetSy (odds ratio OR=5.98; 95% confidence interval CI: 1.46-24.47, p=0.013). Interaction between PPARγ Pro12Ala and IL6 -174G>C improved prediction of high fasting blood glucose (χ(2)=13.99; df=1; p<0.001). PPARγ Ala12 variant was found protective in patients with IL6 -174GG genotype (OR=0.10; 95% CI: 0.02-0.57, p=0.01), while in the case of IL6 -174C allele carriers, for PPARγ Ala12 carriers, larger odds for high glucose levels compared with Pro12 variant were observed (OR=2.39; 95% CI: 1.11-5.17, p=0.026). Interactions of PPARγ and ACE were significant for BMI. In the group with ACE DD genotype, those with PPARγ Pro12Ala or Ala12Ala genotype have greater odds for obesity (OR=9.98; 95% CI: 1.18-84.14, p=0.034). ----- CONCLUSIONS: PPARγ gene variants can, in interaction with some of its target genes, modulate physiological processes leading to the development of MetSy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleGenetic Testing and Molecular Biomarkers
Numberingvol. 18, no. 1, pp. 32-40
p-ISSN1945-0265
DOIhttps://doi.org/10.1089/gtmb.2013.0344
URN:NBNurn:nbn:hr:105:478688
Publication2014-01
Document URLhttps://doi.org/10.1089/gtmb.2013.0344
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:15:42