prikaz prve stranice dokumenta Antinociceptive effect of botulinum toxin type A on experimental abdominal pain
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Scientific paper - Original scientific paper
Antinociceptive effect of botulinum toxin type A on experimental abdominal pain
European Journal of Pharmacology, 745 (2014); 190-195. https://doi.org/10.1016/j.ejphar.2014.10.038
Drinovac, Višnja; Bach-Rojecky, Lidija; Babić, Ana; Lacković, Zdravko

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Drinovac, V., Bach Rojecky, L., Babić, A. & Lacković, Z. (2014). Antinociceptive effect of botulinum toxin type A on experimental abdominal pain. European Journal of Pharmacology, 745., 190-195. doi: 10.1016/j.ejphar.2014.10.038

Drinovac, Višnja, et al. "Antinociceptive effect of botulinum toxin type A on experimental abdominal pain." European Journal of Pharmacology, vol. 745, 2014, pp. 190-195. https://doi.org/10.1016/j.ejphar.2014.10.038

Drinovac, Višnja, Lidija Bach Rojecky, Ana Babić and Zdravko Lacković. "Antinociceptive effect of botulinum toxin type A on experimental abdominal pain." European Journal of Pharmacology 745 (2014): 190-195. https://doi.org/10.1016/j.ejphar.2014.10.038

Drinovac, V., et al. (2014) 'Antinociceptive effect of botulinum toxin type A on experimental abdominal pain', European Journal of Pharmacology, 745, pp. 190-195. doi: 10.1016/j.ejphar.2014.10.038

Drinovac V, Bach Rojecky L, Babić A, Lacković Z. Antinociceptive effect of botulinum toxin type A on experimental abdominal pain. European Journal of Pharmacology [Internet]. 2014 December 15 [cited 2024 May 04];745:190-195. doi: 10.1016/j.ejphar.2014.10.038

V. Drinovac, L. Bach Rojecky, A. Babić and Z. Lacković, "Antinociceptive effect of botulinum toxin type A on experimental abdominal pain", European Journal of Pharmacology, vol. 745, pp. 190-195, December 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:724295. [Accessed: 04 May 2024]

Metadata
Title (english)Antinociceptive effect of botulinum toxin type A on experimental abdominal pain
AuthorVišnja Drinovac
AuthorLidija Bach-Rojecky
AuthorAna Babić
AuthorZdravko Lacković
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Visceral pain, especially in the abdominal region, represents one of the most common types of pain. Its chronic form is usually very hard to treat by conventional analgesic agents and adjuvants. We investigated the antinociceptive effect of botulinum toxin type A (BTX-A) in male Wistar rats in two models of visceral pain: peritonitis induced by intraperitoneal injection of 1% acetic acid and colitis induced by intracolonic instillation of 0.1% capsaicin. Pain was measured as the number of abdominal writhes. Additionally, referred mechanical sensitivity in the ventral abdominal area was evaluated by von Frey test and the extent of spinal c-Fos expression was immunohistochemically examined. BTX-A significantly reduced the number of abdominal writhes in both models of visceral pain after intrathecal application in a dose of 2 U/kg. In the experimental colitis model, BTX-A (2 U/kg) reduced both referred mechanical allodynia and c-Fos expression in the dorsal horn of the spinal cord (S2/S3 segments). In contrast to intrathecal administration, BTX-A (2 U/kg) administered into the cisterna magna had no effect on pain suggesting that the primary site of its action is a spinal cord.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleEuropean Journal of Pharmacology
Numberingvol. 745, pp. 190-195
p-ISSN0014-2999
DOIhttps://doi.org/10.1016/j.ejphar.2014.10.038
URN:NBNurn:nbn:hr:105:724295
Publication2014-12-15
Document URLhttps://doi.org/10.1016/j.ejphar.2014.10.038
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:15:51