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Scientific paper - Original scientific paper
The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study
Neuropsychiatric Disease and Treatment, 10 (2014); 1243-1253. https://doi.org/10.2147/NDT.S61415
Grošić, Vladimir; Folnegović Grošić, Petra; Kalember, Petra; Bajs Janović, Maja; Radoš, Marko; Mihanović, Mate; Henigsberg, Neven

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Grošić, V., Folnegović Grošić, P., Kalember, P., Bajs Janović, M., Radoš, M., Mihanović, M. & Henigsberg, N. (2014). The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study. Neuropsychiatric Disease and Treatment, 10., 1243-1253. doi: 10.2147/NDT.S61415

Grošić, Vladimir, et al. "The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study." Neuropsychiatric Disease and Treatment, vol. 10, 2014, pp. 1243-1253. https://doi.org/10.2147/NDT.S61415

Grošić, Vladimir, Petra Folnegović Grošić, Petra Kalember, Maja Bajs Janović, Marko Radoš, Mate Mihanović and Neven Henigsberg. "The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study." Neuropsychiatric Disease and Treatment 10 (2014): 1243-1253. https://doi.org/10.2147/NDT.S61415

Grošić, V., et al. (2014) 'The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study', Neuropsychiatric Disease and Treatment, 10, pp. 1243-1253. doi: 10.2147/NDT.S61415

Grošić V, Folnegović Grošić P, Kalember P, Bajs Janović M, Radoš M, Mihanović M, and sur.. The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study. Neuropsychiatric Disease and Treatment [Internet]. 2014 July 07 [cited 2024 December 29];10:1243-1253. doi: 10.2147/NDT.S61415

V. Grošić, et al., "The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study", Neuropsychiatric Disease and Treatment, vol. 10, pp. 1243-1253, July 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:304096. [Accessed: 29 December 2024]

Metadata
Title (english)The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study
AuthorVladimir Grošić
AuthorPetra Folnegović Grošić
AuthorPetra Kalember
AuthorMaja Bajs Janović
AuthorMarko Radoš
AuthorMate Mihanović
AuthorNeven Henigsberg
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
PURPOSE: To investigate the correlates of a clinical therapeutic response by using the parameters measured by proton magnetic resonance spectroscopy after the administration of atypical antipsychotics. ----- PATIENTS AND METHODS: Twenty-five antipsychotic-naïve first-episode patients with schizophrenia were monitored for 12 months. The patients were evaluated using (1)H magnetic resonance spectroscopy in the dorsolateral prefrontal cortex and Positive and Negative Syndrome Scale, Clinical Global Impression Scale of Severity, Tower of London - Drexel University, Letter-Number Span Test, Trail Making Test A, and Personal and Social Performance Scale. They were administered atypical antipsychotics, starting with quetiapine. In the absence of a therapeutic response, another antipsychotic was introduced. ----- RESULTS: After 12 study months, the N-acetylaspartate/creatine (NAA/Cr) level did not significantly change at the whole-group level. Additional analysis revealed a significant rise in the NAA/Cr level in the study group that stayed on the same antipsychotic throughout the study course (P=0.008) and a significant drop in NAA/Cr in the study group that switched antipsychotics (P=0.005). On the whole-group level, no significant correlations between NAA/Cr values and other scores were found at either baseline or after 12 study months. ----- CONCLUSION: One-year treatment with atypical antipsychotics administered to antipsychotic-naïve patients didn't result in a significant rise in the NAA/Cr ratio. However, a significant rise was witnessed in the study group in which a satisfactory therapeutic response had been achieved with a single antipsychotic administration.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleNeuropsychiatric Disease and Treatment
Numberingvol. 10, pp. 1243-1253
p-ISSN1178-2021
DOIhttps://doi.org/10.2147/NDT.S61415
URN:NBNurn:nbn:hr:105:304096
Publication2014-07-07
Document URLhttps://doi.org/10.2147/NDT.S61415
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:17:09