prikaz prve stranice dokumenta Intraoral adenoid cystic carcinoma: is the presence of perineural invasion associated with the size of the primary tumour, local extension, surgical margins, distant metastases, and outcome?
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Scientific paper - Original scientific paper
Intraoral adenoid cystic carcinoma: is the presence of perineural invasion associated with the size of the primary tumour, local extension, surgical margins, distant metastases, and outcome?
British Journal of Oral & Maxillofacial Surgery, 52 (2014), 3; 214-218. https://doi.org/10.1016/j.bjoms.2013.11.009
Lukšić, Ivica; Suton, Petar; Macan, Darko; Dinjar, Kristijan

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Lukšić, I., Suton, P., Macan, D. & Dinjar, K. (2014). Intraoral adenoid cystic carcinoma: is the presence of perineural invasion associated with the size of the primary tumour, local extension, surgical margins, distant metastases, and outcome?. British Journal of Oral & Maxillofacial Surgery, 52. (3), 214-218. doi: 10.1016/j.bjoms.2013.11.009

Lukšić, Ivica, et al. "Intraoral adenoid cystic carcinoma: is the presence of perineural invasion associated with the size of the primary tumour, local extension, surgical margins, distant metastases, and outcome?." British Journal of Oral & Maxillofacial Surgery, vol. 52, no. 3, 2014, pp. 214-218. https://doi.org/10.1016/j.bjoms.2013.11.009

Lukšić, Ivica, Petar Suton, Darko Macan and Kristijan Dinjar. "Intraoral adenoid cystic carcinoma: is the presence of perineural invasion associated with the size of the primary tumour, local extension, surgical margins, distant metastases, and outcome?." British Journal of Oral & Maxillofacial Surgery 52, no. 3 (2014): 214-218. https://doi.org/10.1016/j.bjoms.2013.11.009

Lukšić, I., et al. (2014) 'Intraoral adenoid cystic carcinoma: is the presence of perineural invasion associated with the size of the primary tumour, local extension, surgical margins, distant metastases, and outcome?', British Journal of Oral & Maxillofacial Surgery, 52(3), pp. 214-218. doi: 10.1016/j.bjoms.2013.11.009

Lukšić I, Suton P, Macan D, Dinjar K. Intraoral adenoid cystic carcinoma: is the presence of perineural invasion associated with the size of the primary tumour, local extension, surgical margins, distant metastases, and outcome?. British Journal of Oral & Maxillofacial Surgery [Internet]. 2014 March [cited 2024 April 28];52(3):214-218. doi: 10.1016/j.bjoms.2013.11.009

I. Lukšić, P. Suton, D. Macan and K. Dinjar, "Intraoral adenoid cystic carcinoma: is the presence of perineural invasion associated with the size of the primary tumour, local extension, surgical margins, distant metastases, and outcome?", British Journal of Oral & Maxillofacial Surgery, vol. 52, no. 3, pp. 214-218, March 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:133536. [Accessed: 28 April 2024]

Metadata
Title (english)Intraoral adenoid cystic carcinoma: is the presence of perineural invasion associated with the size of the primary tumour, local extension, surgical margins, distant metastases, and outcome?
AuthorIvica Lukšić
AuthorPetar Suton
AuthorDarko Macan
AuthorKristijan Dinjar
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Adenoid cystic carcinoma is the most common malignancy of the minor salivary glands, and its biological behaviour is characterised by slow and indolent growth; rare involvement of regional lymph nodes; a high propensity for perineural invasion; multiple or delayed recurrences, or both; and a high incidence of distant metastases. Our aim was to find out the relation between the presence of perineural invasion and these factors. Between 1 January 1984 and 1 May 2008, 26 cases of adenoid cystic carcinoma of the intraoral salivary glands, which had initially been treated surgically, were reviewed retrospectively. The most common site was the palate, and perineural invasion was reported in 13 of the 26 resected specimens. There was no significant association between it and the size of the primary tumour (OR=1.0; p=1.00), invasion of the surgical margins (OR=2.08; p=0.4), the presence of distant metastases (OR=3.43; p=0.197), or local control (p=0.76). It was exclusively present in patients with local extension, and was significantly associated with outcome (p=0.04). Resection with clear margins is the gold standard of care for patients with intraoral adenoid cystic carcinoma, and the role of adjuvant irradiation remains controversial. Given its paradoxical and complex biological behaviour, large studies with long term follow-up are needed to define the clinicopathological and immunohistochemical variables associated with outcome, as well as the optimal treatment.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleBritish Journal of Oral & Maxillofacial Surgery
Numberingvol. 52, no. 3, pp. 214-218
p-ISSN0266-4356
DOIhttps://doi.org/10.1016/j.bjoms.2013.11.009
URN:NBNurn:nbn:hr:105:133536
Publication2014-03
Document URLhttps://doi.org/10.1016/j.bjoms.2013.11.009
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:18:47