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Scientific paper - Review paper
Karbapenemaze gram-negativnih bakterija
Liječnički vjesnik, 136 (2014), 3-4; 94-103. urn:nbn:hr:105:615960
Bedenić, Branka; Sardelić, Sanda; Vranić-Ladavac, Mirna; Barišić, Nada; Ladavac, Ranko

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Bedenić, B., Sardelić, S., Vranić Ladavac, M., Barišić, N. & Ladavac, R. (2014). Karbapenemaze gram-negativnih bakterija . Liječnički vjesnik, 136. (3-4), 94-103. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:615960

Bedenić, Branka, et al. "Karbapenemaze gram-negativnih bakterija ." Liječnički vjesnik, vol. 136, no. 3-4, 2014, pp. 94-103. https://urn.nsk.hr/urn:nbn:hr:105:615960

Bedenić, Branka, Sanda Sardelić, Mirna Vranić Ladavac, Nada Barišić and Ranko Ladavac. "Karbapenemaze gram-negativnih bakterija ." Liječnički vjesnik 136, no. 3-4 (2014): 94-103. https://urn.nsk.hr/urn:nbn:hr:105:615960

Bedenić, B., et al. (2014) 'Karbapenemaze gram-negativnih bakterija ', Liječnički vjesnik, 136(3-4), pp. 94-103. Available at: https://urn.nsk.hr/urn:nbn:hr:105:615960 (Accessed 28 April 2024)

Bedenić B, Sardelić S, Vranić Ladavac M, Barišić N, Ladavac R. Karbapenemaze gram-negativnih bakterija . Liječnički vjesnik [Internet]. 2014 March [cited 2024 April 28];136(3-4):94-103. Available at: https://urn.nsk.hr/urn:nbn:hr:105:615960

B. Bedenić, S. Sardelić, M. Vranić Ladavac, N. Barišić and R. Ladavac, "Karbapenemaze gram-negativnih bakterija ", Liječnički vjesnik, vol. 136, no. 3-4, pp. 94-103, March 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:615960. [Accessed: 28 April 2024]

Metadata
Title (croatian)Karbapenemaze gram-negativnih bakterija
Title (english)Carbapenemases of gram-negative bacteria
AuthorBranka Bedenić
AuthorSanda Sardelić
AuthorMirna Vranić-Ladavac
AuthorNada Barišić
AuthorRanko Ladavac
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Carbapenems are often antibiotics of last resort for the treatment of severe infections. They are stable to most beta-lactamases produced by gram-negative bacteria. However, bacterial enzymes named carbapenemases can efficiently hydrolyze carbapenems. They are produced most frequently by Enterobacteriaceae and non-fermentative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannnii. They belong to group A (KPC, SME, IMI, NMC), B (VIM, IMP, SPM, GIM, NDM, SIM, DIM, AIM) and D (OXA-23, OXA-24, OXA-48, OXA-58, OXA-143). The accurate and rapid laboratory identification of carbapenem-resistant isolates is important to prevent spread of such multidrug resistant strains and to avoid therapeutic failures. Therapeutic options are often limited because carbapenemases are encoded on mobile genetic elements which often harbour resistance genes to other groups of antibiotics. Thus, colistin is often the only therapeutic option.
Abstract (croatian)
Karbapenemi su često jedina terapijska opcija za liječenje teških infekcija. Stabilni su prema većini b-laktamaza gram-negativnih bakterija, ali neke b-laktamaze, koje se zovu karbapenemaze, mogu ih djelotvorno hidrolizirati. Nalazimo ih u izolatima enterobakterija i nefermentativnih bakterija kao što su Pseudomonas aeruginosa i Acinetobacter baumannii. Dijele se u klase A (KPC, SME, IMI, NMC), B (VIM, IMP, SPM, GIM, NDM, SIM, DIM, AIM) i D (OXA-23, OXA-24, OXA-48, OXA-58, OXA-143). Pravilna i brza identifikacija karbapenem-rezistentnih izolata u laboratoriju važna je kako bi se spriječilo širenje takvih sojeva unutar bolnica i kako bi se izbjegao terapijski neuspjeh. Terapijske opcije vrlo su ograničene zbog toga što prenosivi genski elementi koji kodiraju te b-laktamaze obično sadržavaju i gene rezistencije na ostale antibiotike i često ostaje kolistin kao jedini lijek izbora.
Keywords (english)
Languagecroatian
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleLiječnički vjesnik
Numberingvol. 136, no. 3-4, pp. 94-103
p-ISSN0024-3477
URN:NBNurn:nbn:hr:105:615960
Publication2014-03
Document URLhttp://lijecnicki-vjesnik.hlz.hr/lijecnicki-vjesnik/karbapenemaze-gram-negativnih-bakterija/
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:00:28