prikaz prve stranice dokumenta Activated coagulation time vs. intrinsically activated modified rotational thromboelastometry in assessment of hemostatic disturbances and blood loss after protamine administration in elective cardiac surgery: analysis from the clinical trial (NCT01281397
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Scientific paper - Original scientific paper
Activated coagulation time vs. intrinsically activated modified rotational thromboelastometry in assessment of hemostatic disturbances and blood loss after protamine administration in elective cardiac surgery: analysis from the clinical trial (NCT01281397)
Journal of Cardiothoracic Surgery, 9 (2014); 129. https://doi.org/10.1186/1749-8090-9-129
Petričević, Mate; Biočina, Bojan; Miličić, Davor; Svetina, Lucija; Boban, Marko; Lekić, Ante; Konosić, Sanja; Milošević, Milan; Gašparović, Hrvoje

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Petričević, M., Biočina, B., Miličić, D., Svetina, L., Boban, M., Lekić, A. ... Gašparović, H. (2014). Activated coagulation time vs. intrinsically activated modified rotational thromboelastometry in assessment of hemostatic disturbances and blood loss after protamine administration in elective cardiac surgery: analysis from the clinical trial (NCT01281397). Journal of Cardiothoracic Surgery, 9., 129. doi: 10.1186/1749-8090-9-129

Petričević, Mate, et al. "Activated coagulation time vs. intrinsically activated modified rotational thromboelastometry in assessment of hemostatic disturbances and blood loss after protamine administration in elective cardiac surgery: analysis from the clinical trial (NCT01281397)." Journal of Cardiothoracic Surgery, vol. 9, 2014, p. 129. https://doi.org/10.1186/1749-8090-9-129

Petričević, Mate, Bojan Biočina, Davor Miličić, Lucija Svetina, Marko Boban, Ante Lekić, Sanja Konosić, Milan Milošević and Hrvoje Gašparović. "Activated coagulation time vs. intrinsically activated modified rotational thromboelastometry in assessment of hemostatic disturbances and blood loss after protamine administration in elective cardiac surgery: analysis from the clinical trial (NCT01281397)." Journal of Cardiothoracic Surgery 9 (2014): 129. https://doi.org/10.1186/1749-8090-9-129

Petričević, M., et al. (2014) 'Activated coagulation time vs. intrinsically activated modified rotational thromboelastometry in assessment of hemostatic disturbances and blood loss after protamine administration in elective cardiac surgery: analysis from the clinical trial (NCT01281397)', Journal of Cardiothoracic Surgery, 9, p. 129. doi: 10.1186/1749-8090-9-129

Petričević M, Biočina B, Miličić D, Svetina L, Boban M, Lekić A, and sur.. Activated coagulation time vs. intrinsically activated modified rotational thromboelastometry in assessment of hemostatic disturbances and blood loss after protamine administration in elective cardiac surgery: analysis from the clinical trial (NCT01281397). Journal of Cardiothoracic Surgery [Internet]. 2014 September 17 [cited 2024 May 01];9:129. doi: 10.1186/1749-8090-9-129

M. Petričević, et al., "Activated coagulation time vs. intrinsically activated modified rotational thromboelastometry in assessment of hemostatic disturbances and blood loss after protamine administration in elective cardiac surgery: analysis from the clinical trial (NCT01281397)", Journal of Cardiothoracic Surgery, vol. 9, p. 129, September 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:924524. [Accessed: 01 May 2024]

Metadata
Title (english)Activated coagulation time vs. intrinsically activated modified rotational thromboelastometry in assessment of hemostatic disturbances and blood loss after protamine administration in elective cardiac surgery: analysis from the clinical trial (NCT01281397)
AuthorMate Petričević
AuthorBojan Biočina
AuthorDavor Miličić
AuthorLucija Svetina
AuthorMarko Boban
AuthorAnte Lekić
AuthorSanja Konosić
AuthorMilan Milošević
AuthorHrvoje Gašparović
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: Excessive bleeding after cardiopulmonary bypass (CPB) is risk factor for adverse outcomes after elective cardiac surgery (ECS). Although many different point-of-care devices to diagnose hemostatic disturbances after CPB are available, the best test is still unclear. The study aim was to compare the accuracy of hemostatic disorder detection between two point-of-care devices. ----- METHODS: We enrolled 148 patients (105 male and 43 female) undergoing ECS in a prospective observational study. Rotational thromboelastometry (TEM, with InTEM test), and Activated coagulation time (ACT) measurement were performed 15 min after protamine administration. The cohort group was divided into two subgroups according to occurrence of excessive postoperative bleeding. Endpoints were defined in two ways: as total amount of chest tube output (CTO) and blood product transfusion requirements. ----- RESULTS: Total amount of CTO value of 1507,50 mL presented 75th percentile of distribution, thus cut-off value for bleeder category. InTEM parameters, but not ACT, correlated significantly with CTO. InTEM parameters with the strongest correlation to CTO were tested for accuracy in predicting excessive postoperative bleeding using ROC analysis. InTEM A 10 value of 38 mm, InTEM A 20 value of 49 mm and InTEM A 30 value of 51 mm delineated bleeding tendency. Patients with total amount of CTO exceeding 75th percentile were more frequently transfused with fresh frozen plasma (51.4% vs. 9.9%, p < 0.001), fibrinogen concentrate (21.6% vs. 2.7%, p = 0.001) and platelet concentrate (13.5% vs. 0.9%, p = 0.004). ----- CONCLUSION: Our study showed that InTEM test, but not ACT is useful in prediction of bleeding tendency after protamine administration following weaning from CPB. InTEM test could be used as a first line test in screening of possible hemostatic disorder following protamine administration.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleJournal of Cardiothoracic Surgery
Numberingvol. 9, p. 129
p-ISSN1749-8090
DOIhttps://doi.org/10.1186/1749-8090-9-129
URN:NBNurn:nbn:hr:105:924524
Publication2014-09-17
Document URLhttps://doi.org/10.1186/1749-8090-9-129
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:03:19