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Scientific paper - Original scientific paper
Extraordinary neoteny of synaptic spines in the human prefrontal cortex
Proceedings of the National Academy of Sciences, 108 (2011), 32; 13281-13286. https://doi.org/10.1073/pnas.1105108108
Petanjek, Zdravko; Judaš, Miloš; Šimić, Goran; Rašin, Mladen Roko; Uylings, Harry B. M.; Rakic, Pasko; Kostović, Ivica

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Petanjek, Z., Judaš, M., Šimić, G., Rašin, M. R., Uylings, H. B. M., Rakic, P. & Kostović, I. (2011). Extraordinary neoteny of synaptic spines in the human prefrontal cortex. Proceedings of the National Academy of Sciences, 108. (32), 13281-13286. doi: 10.1073/pnas.1105108108

Petanjek, Zdravko, et al. "Extraordinary neoteny of synaptic spines in the human prefrontal cortex." Proceedings of the National Academy of Sciences, vol. 108, no. 32, 2011, pp. 13281-13286. https://doi.org/10.1073/pnas.1105108108

Petanjek, Zdravko, Miloš Judaš, Goran Šimić, Mladen Roko Rašin, Harry B. M. Uylings, Pasko Rakic and Ivica Kostović. "Extraordinary neoteny of synaptic spines in the human prefrontal cortex." Proceedings of the National Academy of Sciences 108, no. 32 (2011): 13281-13286. https://doi.org/10.1073/pnas.1105108108

Petanjek, Z., et al. (2011) 'Extraordinary neoteny of synaptic spines in the human prefrontal cortex', Proceedings of the National Academy of Sciences, 108(32), pp. 13281-13286. doi: 10.1073/pnas.1105108108

Petanjek Z, Judaš M, Šimić G, Rašin MR, Uylings HBM, Rakic P, and sur.. Extraordinary neoteny of synaptic spines in the human prefrontal cortex. Proceedings of the National Academy of Sciences [Internet]. 2011 August 09 [cited 2024 December 24];108(32):13281-13286. doi: 10.1073/pnas.1105108108

Z. Petanjek, et al., "Extraordinary neoteny of synaptic spines in the human prefrontal cortex", Proceedings of the National Academy of Sciences, vol. 108, no. 32, pp. 13281-13286, August 2011. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:102068. [Accessed: 24 December 2024]

Metadata
Title (english)Extraordinary neoteny of synaptic spines in the human prefrontal cortex
AuthorZdravko Petanjek
AuthorMiloš Judaš
AuthorGoran Šimić
AuthorMladen Roko Rašin
AuthorHarry B. M. Uylings
AuthorPasko Rakic
AuthorIvica Kostović
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The major mechanism for generating diversity of neuronal connections beyond their genetic determination is the activity-dependent stabilization and selective elimination of the initially overproduced synapses [Changeux JP, Danchin A (1976) Nature 264:705-712]. The largest number of supranumerary synapses has been recorded in the cerebral cortex of human and nonhuman primates. It is generally accepted that synaptic pruning in the cerebral cortex, including prefrontal areas, occurs at puberty and is completed during early adolescence [Huttenlocher PR, et al. (1979) Brain Res 163:195-205]. In the present study we analyzed synaptic spine density on the dendrites of layer IIIC cortico-cortical and layer V cortico-subcortical projecting pyramidal neurons in a large sample of human prefrontal cortices in subjects ranging in age from newborn to 91 y. We confirm that dendritic spine density in childhood exceeds adult values by two- to threefold and begins to decrease during puberty. However, we also obtained evidence that overproduction and developmental remodeling, including substantial elimination of synaptic spines, continues beyond adolescence and throughout the third decade of life before stabilizing at the adult level. Such an extraordinarily long phase of developmental reorganization of cortical neuronal circuitry has implications for understanding the effect of environmental impact on the development of human cognitive and emotional capacities as well as the late onset of human-specific neuropsychiatric disorders.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleProceedings of the National Academy of Sciences
Numberingvol. 108, no. 32, pp. 13281-13286
p-ISSN0027-8424
DOIhttps://doi.org/10.1073/pnas.1105108108
URN:NBNurn:nbn:hr:105:102068
Publication2011-08-09
Document URLhttps://doi.org/10.1073/pnas.1105108108
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:04:42