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Scientific paper - Original scientific paper
The role of classic risk factors and prothrombotic factor gene mutations in ischemic stroke risk development in young and middle-aged individuals
Journal of Stroke and Cerebrovascular Diseases, 23 (2014), 3; e171-e176. https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.09.025
Supanc, Višnja; Sonicki, Zdenko; Vukasović, Ines; Vargek Solter, Vesna; Zavoreo, Iris; Bašić Kes, Vanja

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Supanc, V., Sonicki, Z., Vukasović, I., Vargek Solter, V., Zavoreo, I. & Bašić Kes, V. (2014). The role of classic risk factors and prothrombotic factor gene mutations in ischemic stroke risk development in young and middle-aged individuals. Journal of Stroke and Cerebrovascular Diseases, 23. (3), e171-e176. doi: 10.1016/j.jstrokecerebrovasdis.2013.09.025

Supanc, Višnja, et al. "The role of classic risk factors and prothrombotic factor gene mutations in ischemic stroke risk development in young and middle-aged individuals." Journal of Stroke and Cerebrovascular Diseases, vol. 23, no. 3, 2014, pp. e171-e176. https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.09.025

Supanc, Višnja, Zdenko Sonicki, Ines Vukasović, Vesna Vargek Solter, Iris Zavoreo and Vanja Bašić Kes. "The role of classic risk factors and prothrombotic factor gene mutations in ischemic stroke risk development in young and middle-aged individuals." Journal of Stroke and Cerebrovascular Diseases 23, no. 3 (2014): e171-e176. https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.09.025

Supanc, V., et al. (2014) 'The role of classic risk factors and prothrombotic factor gene mutations in ischemic stroke risk development in young and middle-aged individuals', Journal of Stroke and Cerebrovascular Diseases, 23(3), pp. e171-e176. doi: 10.1016/j.jstrokecerebrovasdis.2013.09.025

Supanc V, Sonicki Z, Vukasović I, Vargek Solter V, Zavoreo I, Bašić Kes V. The role of classic risk factors and prothrombotic factor gene mutations in ischemic stroke risk development in young and middle-aged individuals. Journal of Stroke and Cerebrovascular Diseases [Internet]. 2014 March [cited 2024 April 27];23(3):e171-e176. doi: 10.1016/j.jstrokecerebrovasdis.2013.09.025

V. Supanc, Z. Sonicki, I. Vukasović, V. Vargek Solter, I. Zavoreo and V. Bašić Kes, "The role of classic risk factors and prothrombotic factor gene mutations in ischemic stroke risk development in young and middle-aged individuals", Journal of Stroke and Cerebrovascular Diseases, vol. 23, no. 3, pp. e171-e176, March 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:487603. [Accessed: 27 April 2024]

Metadata
Title (english)The role of classic risk factors and prothrombotic factor gene mutations in ischemic stroke risk development in young and middle-aged individuals
AuthorVišnja Supanc
AuthorZdenko Sonicki
AuthorInes Vukasović
AuthorVesna Vargek Solter
AuthorIris Zavoreo
AuthorVanja Bašić Kes
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: In young individuals, a genetically predisposing hypercoagulability and classic modifying risk factors can act synergistically on the ischemic stroke risk development. The aim of the study was to compare the prevalence of classic vascular risk factors and polymorphisms of the G20210A coagulation factor II (prothrombin), Arg506Glu coagulation factor V Leiden, C677T methylenetetrahydrofolate reductase (MTHFR), and 4G/5G plasminogen activator inhibitor-1 (PAI-1) and the impact of these gene mutations and classic vascular risk factors on the overall stroke risk in individuals aged 55 years or younger. ----- METHODS: The study included 155 stroke patients aged 55 years or younger and 150 control subjects. Stroke prevalence and odds ratio (OR) were assessed for the following parameters: G20210A prothrombin, Arg506Glu factor V Leiden, C677T MTHFR, and 4G/5G PAI-1 polymorphisms; total number of study polymorphisms in a particular subject (genetic sum); and classic vascular risk factors of hypertension, obesity, diabetes mellitus, cigarette smoking, hypercholesterolemia, hypertriglyceridemia, and elevated levels of low-density lipoprotein (LDL) cholesterol and very low-density lipoprotein cholesterol. ----- RESULTS: The prevalence of hypertension (P < .001), smoking (P < .001), decreased HDL cholesterol levels (P < .001), obesity (P = .001), elevated LDL cholesterol (P = .036), C677T MTHFR polymorphism (P < .001), and genetic sum was significantly higher in the group of stroke patients. The following parameters were found to act as independent risk factors for ischemic stroke: decreased HDL cholesterol level (P < .001; OR 4.618; 95% confidence interval [CI] 2.381-8.957); hypertension (P = .001; OR 2.839; 95% CI 1.519-5.305); obesity (P = .040; OR 2.148; 95% CI 1.036-4.457); smoking (P = .001; OR 2.502; 95% CI 1.436-4.359); and genetic sum as a continuous variable (P < .01; OR 2.307; 95% CI 1.638-3.250). ----- CONCLUSIONS: Gene mutations of the procoagulable and proatherosclerotic factors investigated exerted a synergistic action in the development of overall risk of ischemic stroke in young and middle-aged individuals.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Stroke and Cerebrovascular Diseases
Numberingvol. 23, no. 3, pp. e171-e176
p-ISSN1052-3057
DOIhttps://doi.org/10.1016/j.jstrokecerebrovasdis.2013.09.025
URN:NBNurn:nbn:hr:105:487603
Publication2014-03
Document URLhttps://doi.org/10.1016/j.jstrokecerebrovasdis.2013.09.025
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:05:28