prikaz prve stranice dokumenta The influence of body position on cerebrospinal fluid pressure gradient and movement in cats with normal and impaired craniospinal communication
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Scientific paper - Original scientific paper
The influence of body position on cerebrospinal fluid pressure gradient and movement in cats with normal and impaired craniospinal communication
PLoS ONE, 9 (2014), 4; e95229. https://doi.org/10.1371/journal.pone.0095229
Klarica, Marijan; Radoš, Milan; Erceg, Gorislav; Petošić, Antonio; Jurjević, Ivana; Orešković, Darko

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Klarica, M., Radoš, M., Erceg, G., Petošić, A., Jurjević, I. & Orešković, D. (2014). The influence of body position on cerebrospinal fluid pressure gradient and movement in cats with normal and impaired craniospinal communication. PLoS ONE, 9. (4). doi: 10.1371/journal.pone.0095229

Klarica, Marijan, et al. "The influence of body position on cerebrospinal fluid pressure gradient and movement in cats with normal and impaired craniospinal communication." PLoS ONE, vol. 9, no. 4, 2014. https://doi.org/10.1371/journal.pone.0095229

Klarica, Marijan, Milan Radoš, Gorislav Erceg, Antonio Petošić, Ivana Jurjević and Darko Orešković. "The influence of body position on cerebrospinal fluid pressure gradient and movement in cats with normal and impaired craniospinal communication." PLoS ONE 9, no. 4 (2014). https://doi.org/10.1371/journal.pone.0095229

Klarica, M., et al. (2014) 'The influence of body position on cerebrospinal fluid pressure gradient and movement in cats with normal and impaired craniospinal communication', PLoS ONE, 9(4). doi: 10.1371/journal.pone.0095229

Klarica M, Radoš M, Erceg G, Petošić A, Jurjević I, Orešković D. The influence of body position on cerebrospinal fluid pressure gradient and movement in cats with normal and impaired craniospinal communication. PLoS ONE [Internet]. 2014 April 18 [cited 2024 November 09];9(4). doi: 10.1371/journal.pone.0095229

M. Klarica, M. Radoš, G. Erceg, A. Petošić, I. Jurjević and D. Orešković, "The influence of body position on cerebrospinal fluid pressure gradient and movement in cats with normal and impaired craniospinal communication", PLoS ONE, vol. 9, no. 4, April 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:384911. [Accessed: 09 November 2024]

Metadata
Title (english)The influence of body position on cerebrospinal fluid pressure gradient and movement in cats with normal and impaired craniospinal communication
AuthorMarijan Klarica
AuthorMilan Radoš
AuthorGorislav Erceg
AuthorAntonio Petošić
AuthorIvana Jurjević
AuthorDarko Orešković
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Intracranial hypertension is a severe therapeutic problem, as there is insufficient knowledge about the physiology of cerebrospinal fluid (CSF) pressure. In this paper a new CSF pressure regulation hypothesis is proposed. According to this hypothesis, the CSF pressure depends on the laws of fluid mechanics and on the anatomical characteristics inside the cranial and spinal space, and not, as is today generally believed, on CSF secretion, circulation and absorption. The volume and pressure changes in the newly developed CSF model, which by its anatomical dimensions and basic biophysical features imitates the craniospinal system in cats, are compared to those obtained on cats with and without the blockade of craniospinal communication in different body positions. During verticalization, a long-lasting occurrence of negative CSF pressure inside the cranium in animals with normal cranio-spinal communication was observed. CSF pressure gradients change depending on the body position, but those gradients do not enable unidirectional CSF circulation from the hypothetical site of secretion to the site of absorption in any of them. Thus, our results indicate the existence of new physiological/pathophysiological correlations between intracranial fluids, which opens up the possibility of new therapeutic approaches to intracranial hypertension.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePLoS ONE
Numberingvol. 9, no. 4, e95229
p-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0095229
URN:NBNurn:nbn:hr:105:384911
Publication2014-04-18
Document URLhttp://doi.org/10.1371/journal.pone.0095229
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:07:32