prikaz prve stranice dokumenta Polymorphisms of interleukin-23 receptor in patients with inflammatory bowel disease in a Croatian tertiary center
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Scientific paper - Original scientific paper
Polymorphisms of interleukin-23 receptor in patients with inflammatory bowel disease in a Croatian tertiary center
Collegium Antropologicum, 37 (2013), 4; 1171-1177. urn:nbn:hr:105:329916
Mihaljević, Silvio; Kibel, Aleksandar; Štefanić, Mario; Glavaš-Obrovac, Ljubica; Takač, Boris; Krznarić, Željko; Samardžija, Marina; Pinotić, Ljerka; Milas, Josip; Segec, Ivan

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Mihaljević, S., Kibel, A., Štefanić, M., Glavaš Obrovac, Lj., Takač, B., Krznarić, Ž. ... Segec, I. (2013). Polymorphisms of interleukin-23 receptor in patients with inflammatory bowel disease in a Croatian tertiary center . Collegium Antropologicum, 37. (4), 1171-1177. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:329916

Mihaljević, Silvio, et al. "Polymorphisms of interleukin-23 receptor in patients with inflammatory bowel disease in a Croatian tertiary center ." Collegium Antropologicum, vol. 37, no. 4, 2013, pp. 1171-1177. https://urn.nsk.hr/urn:nbn:hr:105:329916

Mihaljević, Silvio, Aleksandar Kibel, Mario Štefanić, Ljubica Glavaš Obrovac, Boris Takač, Željko Krznarić, Marina Samardžija, Ljerka Pinotić, Josip Milas and Ivan Segec. "Polymorphisms of interleukin-23 receptor in patients with inflammatory bowel disease in a Croatian tertiary center ." Collegium Antropologicum 37, no. 4 (2013): 1171-1177. https://urn.nsk.hr/urn:nbn:hr:105:329916

Mihaljević, S., et al. (2013) 'Polymorphisms of interleukin-23 receptor in patients with inflammatory bowel disease in a Croatian tertiary center ', Collegium Antropologicum, 37(4), pp. 1171-1177. Available at: https://urn.nsk.hr/urn:nbn:hr:105:329916 (Accessed 06 May 2024)

Mihaljević S, Kibel A, Štefanić M, Glavaš Obrovac Lj, Takač B, Krznarić Ž, and sur.. Polymorphisms of interleukin-23 receptor in patients with inflammatory bowel disease in a Croatian tertiary center . Collegium Antropologicum [Internet]. 2013 December [cited 2024 May 06];37(4):1171-1177. Available at: https://urn.nsk.hr/urn:nbn:hr:105:329916

S. Mihaljević, et al., "Polymorphisms of interleukin-23 receptor in patients with inflammatory bowel disease in a Croatian tertiary center ", Collegium Antropologicum, vol. 37, no. 4, pp. 1171-1177, December 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:329916. [Accessed: 06 May 2024]

Metadata
Title (english)Polymorphisms of interleukin-23 receptor in patients with inflammatory bowel disease in a Croatian tertiary center
Title (croatian)Polimorfizmi interleukin-23 receptora u pacijenata s upalnim bolestima crijeva u Hrvatskom tercijarnom centru
AuthorSilvio Mihaljević
AuthorAleksandar Kibel
AuthorMario Štefanić
AuthorLjubica Glavaš-Obrovac
AuthorBoris Takač
AuthorŽeljko Krznarić
AuthorMarina Samardžija
AuthorLjerka Pinotić
AuthorJosip Milas
AuthorIvan Segec
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The Interleukin-23 signalling pathway is important for the differentiation of TH17 lymphocytes and is involved in the pathogenesis of Inflammatory bowel disease. Polymorphisms in the IL-23 receptor gene were previously found to be associated with Inflammatory bowel disease in various populations. The aim of this study was to determine whether the specific rs11209026 and rs7530511 single-nucleotide polymorphisms in the Interleukin-23 receptor gene are associated with Crohn's disease and ulcerative colitis in a Croatian patient population. A total of 50 patients with Crohn's disease and 93 patients with ulcerative colitis, as well as 99 healthy control subjects were included in the study. The results determined a significantly higher occurrence of rs11209026 in control group compared to patients with inflammatory bowel disease, suggesting a protective effect of this polymorphism. The rs11209026 variant was strongly associated with Crohn's disease, but it was absent in ulcerative colitis. However, there was no significant association between the rs7530511 polymorphism with either ulcerative colitis or Crohn's disease. Associations presented in this study give potentially important insight into the roles of specific Interleukin-23 receptor polymorphisms in Crohn's disease pathogenesis in the Croatian population.
Abstract (croatian)
Interleukin-23 signalni put je važan u diferencijaciji TH17 limfocita i uključen je u patogenezu upalnih bolesti crijeva. Polimorfizmi interleukin-23 receptora u ranijim istraživanjima povezivani su s upalnim bolestima crijeva u različitim populacijama. Cilj ovog istraživanja bio je odrediti povezanost specifičnih rs11209026 i rs7530511 polimorfizama pojedinačnog nukleotida (eng. single nucleotide polymorphism) interleukin-23 receptora s Crohnovom bolešću i ulceroznim kolitisom u hrvatskoj populaciji pacijenata tercijarnog kliničkog centra. Ukupno 50 pacijenata s Crohnovom bolešću i 93 pacijenta s ulceroznim kolitisom, kao i 99 zdravih kontrolnih ispitanika uključeno je prospektivno. Rezultati ukazuju na značajno veću pojavnost rs11209026 polimorfizma u zdravih ispitanika u odnosu na pacijente s upalnim bolestima crijeva, što sugerira protektivan učinak ovog polimorfizma. Kada se analiziraju posebno pacijenti s Crohnovom bolešću i s ulceroznim kolitisom, povezanost je bila značajna za Crohnovu bolest, ali odsutna za ulcerozni kolitis. rs7530511 polimorfizam, međutim, nije bio značajno povezan niti s Crohnovom bolešću niti s ulceroznim kolitisom. Povezanosti s polimorfizmima prikazane u ovom istraživanju predstavljaju potencijalno važan uvid u uloge polimorfizama interleukin-23 receptora u patogenezi Crohnove bolesti u hrvatskoj populaciji.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 37, no. 4, pp. 1171-1177
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:329916
Publication2013-12
Document URLhttps://hrcak.srce.hr/118363
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:15:23