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Scientific paper - Review paper
Prostate cancer stroma: an important factor in cancer growth and progression
Bosnian Journal of Basic Medical Sciences, 15 (2015), 2; 1-8. https://doi.org/10.17305/bjbms.2015.449
Krušlin, Božo; Ulamec, Monika; Tomas, Davor

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Krušlin, B., Ulamec, M. & Tomas, D. (2015). Prostate cancer stroma: an important factor in cancer growth and progression. Bosnian Journal of Basic Medical Sciences, 15. (2), 1-8. doi: 10.17305/bjbms.2015.449

Krušlin, Božo, et al. "Prostate cancer stroma: an important factor in cancer growth and progression." Bosnian Journal of Basic Medical Sciences, vol. 15, no. 2, 2015, pp. 1-8. https://doi.org/10.17305/bjbms.2015.449

Krušlin, Božo, Monika Ulamec and Davor Tomas. "Prostate cancer stroma: an important factor in cancer growth and progression." Bosnian Journal of Basic Medical Sciences 15, no. 2 (2015): 1-8. https://doi.org/10.17305/bjbms.2015.449

Krušlin, B., Ulamec, M. and Tomas, D. (2015) 'Prostate cancer stroma: an important factor in cancer growth and progression', Bosnian Journal of Basic Medical Sciences, 15(2), pp. 1-8. doi: 10.17305/bjbms.2015.449

Krušlin B, Ulamec M, Tomas D. Prostate cancer stroma: an important factor in cancer growth and progression. Bosnian Journal of Basic Medical Sciences [Internet]. 2015 May [cited 2024 December 27];15(2):1-8. doi: 10.17305/bjbms.2015.449

B. Krušlin, M. Ulamec and D. Tomas, "Prostate cancer stroma: an important factor in cancer growth and progression", Bosnian Journal of Basic Medical Sciences, vol. 15, no. 2, pp. 1-8, May 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:283203. [Accessed: 27 December 2024]

Metadata
Title (english)Prostate cancer stroma: an important factor in cancer growth and progression
AuthorBožo Krušlin
AuthorMonika Ulamec
AuthorDavor Tomas
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Reactive stromal changes that occur in different human cancers might play a role in local tumor spreading and progression. Studies done on various human cancers have shown activated stromal cell phenotypes, modified extracellular matrix (ECM) composition, and increased microvessel density. Furthermore, they exhibit biological markers consistent with stroma at the site of wound repair. In prostate cancer, stroma is composed of fibroblasts, myofibroblasts, endothelial cells and immune cells. Predominant cells in the tumorous stroma are, however, fibroblasts/ myofibroblasts. They are responsible for the synthesis, deposition and remodeling of the ECM. Epithelial tumorous cells, in interaction with stromal cells and with the help of various molecules of ECM, create a microenvironment suitable for cancer cell proliferation, movement, and differentiation. In this review, we discussed the role of different stromal components in prostate cancer as well as their potential prognostic and therapeutic significance.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBosnian Journal of Basic Medical Sciences
Numberingvol. 15, no. 2, pp. 1-8
p-ISSN1512-8601
DOIhttps://doi.org/10.17305/bjbms.2015.449
URN:NBNurn:nbn:hr:105:283203
Publication2015-05
Document URLhttps://doi.org/10.17305/bjbms.2015.449
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:23:23