| Abstract (english) | AIM
To investigate the relationship between total serum cholesterol and levels of depression, aggression, and suicidal ideations in war veterans with posttraumatic stress disorder (PTSD) without psychiatric comorbidity.
----- METHODS
A total of 203 male PTSD outpatients were assessed for the presence of depression, aggression, and suicidality using the 17-item Hamilton Depression Rating Scale (HAM-D17), Corrigan Agitated Behavior Scale (CABS), and Scale for Suicide Ideation (SSI), respectively, followed by plasma lipid parameters determination (total cholesterol, high density lipoprotein [HDL]-cholesterol, low density lipoprotein [LDL]-cholesterol, and triglycerides). PTSD severity was assessed using the Clinician-Administered PTSD Scale for DSM-IV, Current and Lifetime Diagnostic Version (CAPS-DX) and the Clinical Global Impressions of Severity Scale (CGI-S), before which Mini-International Neuropsychiatric Interview (MINI) was administered to exclude psychiatric comorbidity and premorbidity.
----- RESULTS
After adjustments for PTSD severity, age, body mass index, marital status, educational level, employment status, use of particular antidepressants, and other lipid parameters (LDL- and HDL- cholesterol and triglycerides), higher total cholesterol was significantly associated with lower odds for having higher suicidal ideation (SSI≥20) (odds ratio [OR] 0.09; 95% confidence interval [CI] 0.03-0.23], clinically significant aggression (CABS≥22) (OR 0.28; 95% CI 0.14-0.59), and at least moderate depressive symptoms (HAM-D17≥17) (OR 0.20; 95% CI 0.08-0.48). Association of total cholesterol and HAM-D17 scores was significantly moderated by the severity of PTSD symptoms (P<0.001).
----- CONCLUSION
Our results indicate that higher total serum cholesterol is associated with lower scores on HAM-D17, CABS, and SSI in patients with chronic PTSD. |
| Abstract (croatian) | Povezanost između ukupnog serumskog kolesterola i depresije, agresije te suicidalnih ideacija kod ratnih veterana s posttraumatskim stresnim poremećajem: presječno istraživanje -----
Cilj: Istražiti odnos između ukupnog serumskog kolesterola i depresije, agresije te suicidalnih ideacija kod ratnih veterana s posttraumatskim stresnim poremećajem (PTSP) bez psihijatrijskog komorbiditeta.
----- Postupci: Ispitali smo prisutnost depresije, agresije te suicidalnih ideacija kod 203 muška pacijenta s PTSP-om koristeći Hamiltonovu ljestvicu depresije od 17 čestica (eng, 17-item Hamilton Depression Rating Scale, HAM-D17), Corriganovu ljestvicu agitiranog ponašanja (eng, Corrigan Agitated Behavior Scale, CABS), odnosno Ljestvicu suicidalnih ideacija (eng, Scale for Suicide Ideation, SSI) te smo odredili lipide u plazmi (ukupni kolesterol, lipoprotein-kolesterol visoke gustoće, lipoprotein-kolesterol niske gustoće, i trigliceride). Jačina PTSP-a određena je Kliničkom ljestvicom za PTSP, trenutnom i cjeloživotnom dijagnostičkom verzijom (eng, Clinician-Administered PTSD Scale for DSM-IV Current and Lifetime Diagnostic Version, eng. CAPS-DX) i Ljestvicom općih kliničkih dojmova o težini bolesti (Clinical Global Impressions of Severity Scale, CGI-S), prije kojih je korišten Mini međunarodni neuropsihijatrijski intervju (Mini-International Neuropsychiatric Intervju, MINI) kako bismo isključili psihijatrijski komorbiditet i premorbiditet.
----- Rezultati: Nakon prilagodbe za jačinu PTSP-a, dob, indeks tjelesne mase, bračni status, razinu obrazovanja, zaposlenost, uporabu određenih antidepresiva i ostale lipidne parametre (lipoprotein-kolesterol visoke i niske gustoće, kolesterol i trigliceride), viši ukupni kolesterol bio je značajno povezan s nižim izgledima više suicidalne ideacije (SSI≥20) (omjer izgleda [eng, odds ratio OR] 0,09; 95% raspon pouzdanosti [eng, confidence interval CI] 0,03-0,23], klinički značajnom agresijom (CABS≥22) (OR 0,28; 95% CI 0,14-0,59) i najmanje umjerenim depresivnim simptomima (HAM-D17 ≥17) (OR 0,20; 95% CI 0,08-0,48). Povezanost ukupnog kolesterola i HAM-D17 rezultat bili su značajno moderirani jačinom simptoma PTSP-a (P<0,001).
----- Zaključak: Naši rezultati ukazuju da je viša ukupna razina kolesterola povezana s nižim izračunom HAM-D17, CABS, i SSI ljestvica kod pacijenata s kroničnim PTSP-om. |
