prikaz prve stranice dokumenta Real-time two-dimensional shear wave ultrasound elastography of the liver is a reliable predictor of clinical outcomes and the presence of esophageal varices in patients with compensated liver cirrhosis
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Scientific paper - Original scientific paper
Real-time two-dimensional shear wave ultrasound elastography of the liver is a reliable predictor of clinical outcomes and the presence of esophageal varices in patients with compensated liver cirrhosis
Croatian Medical Journal, 56 (2015), 5; 470-481. https://doi.org/10.3325/cmj.2015.56.470
Grgurević, Ivica; Bokun, Tomislav; Mustapić, Sanda; Trkulja, Vladimir; Heinzl, Renata; Banić, Marko; Puljiz, Željko; Lukšić, Boris; Kujundžić, Milan

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Grgurević, I., Bokun, T., Mustapić, S., Trkulja, V., Heinzl, R., Banić, M. ... Kujundžić, M. (2015). Real-time two-dimensional shear wave ultrasound elastography of the liver is a reliable predictor of clinical outcomes and the presence of esophageal varices in patients with compensated liver cirrhosis. Croatian Medical Journal, 56. (5), 470-481. doi: 10.3325/cmj.2015.56.470

Grgurević, Ivica, et al. "Real-time two-dimensional shear wave ultrasound elastography of the liver is a reliable predictor of clinical outcomes and the presence of esophageal varices in patients with compensated liver cirrhosis." Croatian Medical Journal, vol. 56, no. 5, 2015, pp. 470-481. https://doi.org/10.3325/cmj.2015.56.470

Grgurević, Ivica, Tomislav Bokun, Sanda Mustapić, Vladimir Trkulja, Renata Heinzl, Marko Banić, Željko Puljiz, Boris Lukšić and Milan Kujundžić. "Real-time two-dimensional shear wave ultrasound elastography of the liver is a reliable predictor of clinical outcomes and the presence of esophageal varices in patients with compensated liver cirrhosis." Croatian Medical Journal 56, no. 5 (2015): 470-481. https://doi.org/10.3325/cmj.2015.56.470

Grgurević, I., et al. (2015) 'Real-time two-dimensional shear wave ultrasound elastography of the liver is a reliable predictor of clinical outcomes and the presence of esophageal varices in patients with compensated liver cirrhosis', Croatian Medical Journal, 56(5), pp. 470-481. doi: 10.3325/cmj.2015.56.470

Grgurević I, Bokun T, Mustapić S, Trkulja V, Heinzl R, Banić M, and sur.. Real-time two-dimensional shear wave ultrasound elastography of the liver is a reliable predictor of clinical outcomes and the presence of esophageal varices in patients with compensated liver cirrhosis. Croatian Medical Journal [Internet]. 2015 October [cited 2024 November 22];56(5):470-481. doi: 10.3325/cmj.2015.56.470

I. Grgurević, et al., "Real-time two-dimensional shear wave ultrasound elastography of the liver is a reliable predictor of clinical outcomes and the presence of esophageal varices in patients with compensated liver cirrhosis", Croatian Medical Journal, vol. 56, no. 5, pp. 470-481, October 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:576806. [Accessed: 22 November 2024]

Metadata
Title (english)Real-time two-dimensional shear wave ultrasound elastography of the liver is a reliable predictor of clinical outcomes and the presence of esophageal varices in patients with compensated liver cirrhosis
AuthorIvica Grgurević
AuthorTomislav Bokun
AuthorSanda Mustapić
AuthorVladimir Trkulja
AuthorRenata Heinzl
AuthorMarko Banić
AuthorŽeljko Puljiz
AuthorBoris Lukšić
AuthorMilan Kujundžić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
AIM: Primary: to evaluate predictivity of liver stiffness (LS), spleen stiffness (SS), and their ratio assessed by real-time 2D shear wave elastography (RT-2D-SWE) for adverse outcomes (hepatic decompensation, hepatocellular carcinoma or death; "event") in compensated liver cirrhosis (LC) patients. Secondary: to evaluate ability of these measures to discriminate between cirrhotic patients with/without esophageal varices (EV). ----- METHODS: Predictivity of LS, SS, and LS/SS was assessed in a retrospectively analyzed cohort of compensated LC patients (follow-up cohort) and through comparison with incident patients with decompensated cirrhosis (DC) (cross-sectional cohort). Both cohorts were used to evaluate diagnostic properties regarding EV. ----- RESULTS: In the follow-up cohort (n=44) 18 patients (40.9%) experienced an "event" over a median period of 28 months. LS≥21.5 kPa at baseline was independently associated with 3.4-fold (95% confidence interval [CI] 1.16-10.4, P=0.026) higher risk of event. Association between SS and outcomes was weaker (P=0.056), while there was no association between LS/SS ratio and outcomes. Patients with DC (n=43) had higher LS (35.3 vs 18.3 kPa, adjusted difference 65%, 95% CI 43%-90%; P<0.001) than compensated patients at baseline. Adjusted odds of EV increased by 13% (95% CI 7.0%-20.0%; Plt;0.001) with 1 kPa increase in LS. At cut-offs of 19.7 and 30.3 kPa, LS and SS had 90% and 86.6% negative predictive value, respectively, to exclude EV in compensated patients. ----- CONCLUSION: This is the first evaluation of RT-2D-SWE as a prognostic tool in LC. Although preliminary and gathered in a limited sample, our data emphasize the potential of LS to be a reliable predictor of clinical outcomes and the presence of EV in LC patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 56, no. 5, pp. 470-481
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2015.56.470
URN:NBNurn:nbn:hr:105:576806
Publication2015-10
Document URLhttps://doi.org/10.3325/cmj.2015.56.470
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:27:33