prikaz prve stranice dokumenta Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis
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Scientific paper - Original scientific paper
Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis
Clinical and Experimental Rheumatology, 31 (2013), 5; 803-812. urn:nbn:hr:105:095216
Lukić, Anita; Lukić, Ivan Krešimir; Malčić, Ivan; Batinić, Danica; Milošević, Danko; Rožmanić, Vojko; Saraga, Marijan; Šubat-Dežulović, Mirna; Metličić, Vitomir; Malenica, Branko; Jelušić, Marija

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Lukić, A., Lukić, I. K., Malčić, I., Batinić, D., Milošević, D., Rožmanić, V. ... Jelušić, M. (2013). Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis. Clinical and Experimental Rheumatology, 31. (5), 803-812. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:095216

Lukić, Anita, et al. "Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis." Clinical and Experimental Rheumatology, vol. 31, no. 5, 2013, pp. 803-812. https://urn.nsk.hr/urn:nbn:hr:105:095216

Lukić, Anita, Ivan Krešimir Lukić, Ivan Malčić, Danica Batinić, Danko Milošević, Vojko Rožmanić, Marijan Saraga, et al. "Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis." Clinical and Experimental Rheumatology 31, no. 5 (2013): 803-812. https://urn.nsk.hr/urn:nbn:hr:105:095216

Lukić, A., et al. (2013) 'Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis', Clinical and Experimental Rheumatology, 31(5), pp. 803-812. Available at: https://urn.nsk.hr/urn:nbn:hr:105:095216 (Accessed 24 December 2024)

Lukić A, Lukić IK, Malčić I, Batinić D, Milošević D, Rožmanić V, and sur.. Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis. Clinical and Experimental Rheumatology [Internet]. 2013 September [cited 2024 December 24];31(5):803-812. Available at: https://urn.nsk.hr/urn:nbn:hr:105:095216

A. Lukić, et al., "Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis", Clinical and Experimental Rheumatology, vol. 31, no. 5, pp. 803-812, September 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:095216. [Accessed: 24 December 2024]

Metadata
Title (english)Childhood-onset systemic lupus erythematosus in Croatia: demographic, clinical and laboratory features, and factors influencing time to diagnosis
AuthorAnita Lukić
AuthorIvan Krešimir Lukić
AuthorIvan Malčić
AuthorDanica Batinić
AuthorDanko Milošević
AuthorVojko Rožmanić
AuthorMarijan Saraga
AuthorMirna Šubat-Dežulović
AuthorVitomir Metličić
AuthorBranko Malenica
AuthorMarija Jelušić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
OBJECTIVES Childhood-onset systemic lupus erythematosus (cSLE) presents with diverse clinical features and often with non-classical symptoms that may delay diagnosis and increase risk of morbidity and mortality. This paper aims to analyse incidence, and clinical and laboratory features of cSLE in Croatia between 1991 and 2010, and to identify factors influencing time to diagnosis. ----- RESULTS Medical records at three university-based tertiary care centres were analysed retrospectively for 81 children with cSLE (68 girls). Mean age at onset was 13.4±2.8 yr (interquartile range 3), and annual incidence varied from 1-15 per million at risk. The most frequent clinical and laboratory features were musculoskeletal symptoms (80%) and increased erythrocyte sedimentation rate (96%). The most frequent immunological laboratory findings were the presence of antibodies against histones (86%), double-stranded DNA (73%), and Sm protein (64%), as well as low levels of C3 complement (69%). Haematuria was present in 58% of children, proteinuria in 56%, and biopsy-confirmed lupus nephritis in 43%. Median time from symptom onset to diagnosis was 2 months (range 0-96). Time to diagnosis was inversely associated with ECLAM score (p<0.001), but it showed no association with age, gender, clinical features or distance from the nearest paediatric centre. ----- CONCLUSIONS This is the first large-scale, in-depth study of clinical and laboratory features of cSLE in Croatia. Among all demographic, laboratory and clinical features examined, ECLAM score alone was inversely associated with time to diagnosis. This highlights the need to improve detection of children with fewer symptoms early in the course of the disease, therefore serious consequences for prognosis could be avoided.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleClinical and Experimental Rheumatology
Numberingvol. 31, no. 5, pp. 803-812
p-ISSN0392-856X
URN:NBNurn:nbn:hr:105:095216
Publication2013-09
Document URLhttps://www.clinexprheumatol.org/article.asp?a=6722
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:28:55