prikaz prve stranice dokumenta Validation of Epstein biopsy criteria for insignificant prostate cancer in contemporary cohort of Croatian patients
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Scientific paper - Original scientific paper
Validation of Epstein biopsy criteria for insignificant prostate cancer in contemporary cohort of Croatian patients
Collegium Antropologicum, 39 (2015), 3; 709-711. urn:nbn:hr:105:673381
Tomašković, Igor; Ulamec, Monika; Tomić, Miroslav; Pezelj, Ivan; Grubišić, Igor; Krušlin, Božo

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Tomašković, I., Ulamec, M., Tomić, M., Pezelj, I., Grubišić, I. & Krušlin, B. (2015). Validation of Epstein biopsy criteria for insignificant prostate cancer in contemporary cohort of Croatian patients . Collegium Antropologicum, 39. (3), 709-711. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:673381

Tomašković, Igor, et al. "Validation of Epstein biopsy criteria for insignificant prostate cancer in contemporary cohort of Croatian patients ." Collegium Antropologicum, vol. 39, no. 3, 2015, pp. 709-711. https://urn.nsk.hr/urn:nbn:hr:105:673381

Tomašković, Igor, Monika Ulamec, Miroslav Tomić, Ivan Pezelj, Igor Grubišić and Božo Krušlin. "Validation of Epstein biopsy criteria for insignificant prostate cancer in contemporary cohort of Croatian patients ." Collegium Antropologicum 39, no. 3 (2015): 709-711. https://urn.nsk.hr/urn:nbn:hr:105:673381

Tomašković, I., et al. (2015) 'Validation of Epstein biopsy criteria for insignificant prostate cancer in contemporary cohort of Croatian patients ', Collegium Antropologicum, 39(3), pp. 709-711. Available at: https://urn.nsk.hr/urn:nbn:hr:105:673381 (Accessed 23 November 2024)

Tomašković I, Ulamec M, Tomić M, Pezelj I, Grubišić I, Krušlin B. Validation of Epstein biopsy criteria for insignificant prostate cancer in contemporary cohort of Croatian patients . Collegium Antropologicum [Internet]. 2015 September [cited 2024 November 23];39(3):709-711. Available at: https://urn.nsk.hr/urn:nbn:hr:105:673381

I. Tomašković, M. Ulamec, M. Tomić, I. Pezelj, I. Grubišić and B. Krušlin, "Validation of Epstein biopsy criteria for insignificant prostate cancer in contemporary cohort of Croatian patients ", Collegium Antropologicum, vol. 39, no. 3, pp. 709-711, September 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:673381. [Accessed: 23 November 2024]

Metadata
Title (english)Validation of Epstein biopsy criteria for insignificant prostate cancer in contemporary cohort of Croatian patients
Title (croatian)Patohistološki nalazi bolesnika s rakom prostate liječenih radikalnom prostatektomijom koji su bili podobni za aktivni nadzor
AuthorIgor Tomašković
AuthorMonika Ulamec
AuthorMiroslav Tomić
AuthorIvan Pezelj
AuthorIgor Grubišić
AuthorBožo Krušlin
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Only few reports validated contemporary Epstein criteria for insignificant prostate cancer, and only one being from Europe. Patients with insignificant prostate cancer should be offered active surveillance and spared radical treatment. In our study we tested Epstein biopsy criteria for predicting unfavorable final pathology and biochemical relapse in low risk prostate cancer patients, who were eligible for active surveillance but where treated with radical prostatectomy. Between January 2003 and January 2008, 586 patients were subjected to radical prostatectomy in our institution. Among them, 106 where eligible for active surveillance according to Epstein biopsy criteria for insignificant prostate cancer. We analyzed the presence of adverse pathological findings in the final pathohistological specimen after radical prostatectomy which excludes low risk disease. Adverse pathohistological findings were noted in 41 (38.6%) patients, who could have been offered active surveillance. During the follow up of 48 (12-72) months, biochemical relapse was noted in 6 (5.6%) patients. Although active surveillance is becoming more popular because of the long natural course of prostate cancer and fear of overtreatment of patients with indolent course of disease, both doctors and patients must be aware of potentially significant disease in this group and limitations of current preoperative criteria defining low risk patients.
Abstract (croatian)
Samo je nekoliko radova koji potvrđuju Epsteinove kriterije za karcinome prostate niskog rizika od kojih je samo jedan iz Europe. Aktivni nadzor je legitimna opcija kod lokaliziranog karcinoma prostate niskog rizika. U našem istraživanju testirali smo u skupini bolesnika niskog rizika, koja je liječena radikalnom prostatektomijom, najstrože preoperativne kriterije za aktivni nadzor. Od siječnja 2003. do siječnja 2008. retropubičnoj radikalnoj prostatektomiji podvrgnuto je 586 bolesnika od kojih je 106 bilo podobno za aktivni nadzor prema kombiniranim preoperativnim kriterijima koje su definirali van den Bergh i Carter. Analizirali smo prisutnost nepovoljnih patoloških nalaza na konačnom patohistološkom preparatu nakon prostatektomije koji isključuju bolest niskog rizika. Ukupno, nepovoljan patohistološki nalaz bio je prisutan u 41 bolesnika, što je 38,6% bolesnika kojima je mogao biti ponuđen i aktivni nadzor. Tijekom perioda praćenja od 48 (12-72) mjeseci biokemijski relaps zabilježen je u 6 bolesnika. Premda aktivni nadzor postaje popularan zbog dugog prirodnog tijeka raka prostate i straha od pretjeranog liječenja bolesnika sa indolentnim tijekom bolesti i liječnici i bolesnici moraju biti svjesni potencijalno signifikatne bolesti u ovoj skupini i ograničenja sadašnjih preoperativnih kriterija koji definiraju bolesnike niskog rizika.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 39, no. 3, pp. 709-711
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:673381
Publication2015-09
Document URLhttps://hrcak.srce.hr/166284
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:30:27