prikaz prve stranice dokumenta Nine-month follow-up of the insulin receptor signalling cascade in the brain of streptozotocin rat model of sporadic Alzheimer's disease
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Scientific paper - Original scientific paper
Nine-month follow-up of the insulin receptor signalling cascade in the brain of streptozotocin rat model of sporadic Alzheimer's disease
Journal of Neural Transmission, 122 (2015), 4; 565-576. https://doi.org/10.1007/s00702-014-1323-y
Osmanović Barilar, Jelena; Knezović, Ana; Grünblatt, Edna; Riederer, Peter; Šalković-Petrišić, Melita

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

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Osmanović Barilar, J., Knezović, A., Grünblatt, E., Riederer, P. & Šalković Petrišić, M. (2015). Nine-month follow-up of the insulin receptor signalling cascade in the brain of streptozotocin rat model of sporadic Alzheimer's disease. Journal of Neural Transmission, 122. (4), 565-576. doi: 10.1007/s00702-014-1323-y

Osmanović Barilar, Jelena, et al. "Nine-month follow-up of the insulin receptor signalling cascade in the brain of streptozotocin rat model of sporadic Alzheimer's disease." Journal of Neural Transmission, vol. 122, no. 4, 2015, pp. 565-576. https://doi.org/10.1007/s00702-014-1323-y

Osmanović Barilar, Jelena, Ana Knezović, Edna Grünblatt, Peter Riederer and Melita Šalković Petrišić. "Nine-month follow-up of the insulin receptor signalling cascade in the brain of streptozotocin rat model of sporadic Alzheimer's disease." Journal of Neural Transmission 122, no. 4 (2015): 565-576. https://doi.org/10.1007/s00702-014-1323-y

Osmanović Barilar, J., et al. (2015) 'Nine-month follow-up of the insulin receptor signalling cascade in the brain of streptozotocin rat model of sporadic Alzheimer's disease', Journal of Neural Transmission, 122(4), pp. 565-576. doi: 10.1007/s00702-014-1323-y

Osmanović Barilar J, Knezović A, Grünblatt E, Riederer P, Šalković Petrišić M. Nine-month follow-up of the insulin receptor signalling cascade in the brain of streptozotocin rat model of sporadic Alzheimer's disease. Journal of Neural Transmission [Internet]. 2015 April [cited 2024 November 22];122(4):565-576. doi: 10.1007/s00702-014-1323-y

J. Osmanović Barilar, A. Knezović, E. Grünblatt, P. Riederer and M. Šalković Petrišić, "Nine-month follow-up of the insulin receptor signalling cascade in the brain of streptozotocin rat model of sporadic Alzheimer's disease", Journal of Neural Transmission, vol. 122, no. 4, pp. 565-576, April 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:181257. [Accessed: 22 November 2024]

Metadata
Title (english)Nine-month follow-up of the insulin receptor signalling cascade in the brain of streptozotocin rat model of sporadic Alzheimer's disease
AuthorJelena Osmanović Barilar
AuthorAna Knezović
AuthorEdna Grünblatt
AuthorPeter Riederer
AuthorMelita Šalković-Petrišić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Sporadic Alzheimer disease (sAD) is associated with impairment of insulin receptor (IR) signalling in the brain. Rats used to model sAD develop insulin-resistant brain state following intracerebroventricular treatment with a betacytotoxic drug streptozotocin (STZ-icv). Brain IR signalling has been explored usually at only one time point in periods ≤3 months after the STZ-icv administration. We have investigated insulin signalling in the rat hippocampus at five time points in periods ≤9 months after STZ-icv treatment. Male Wistar rats were given vehicle (control)- or STZ (3 mg/kg)-icv injection and killed 0.5, 1, 3, 6 and 9 months afterwards. Insulin-1 (Ins-1), IR, phospho- and total (p/t)-glycogen synthase kinase 3-β (GSK-3β), p/t-tau and insulin degrading enzyme (IDE) mRNA and/or protein were measured. Acute upregulation of tau and IR mRNA (p < 0.05) was followed by a pronounced downregulation of Ins-1, IR and IDE mRNA (p < 0.05) in the course of time. Acute decrement in p/t-tau and p/t-GSK-3β ratios (p < 0.05) was followed by increment in both ratios (3-6 months, p < 0.05) after which p/t-tau ratio demonstrated a steep rise and p/t-GSK-3β ratio a steep fall up to 9 months (p < 0.05). Acute decline in IDE and IR expression (p < 0.05) was followed by a slow progression of the former and a slow recovery of the latter in 3-9 months. Results indicate a biphasic pattern in time dependency of onset and progression of changes in brain insulin signalling of STZ-icv model (partly reversible acute toxicity and chronic AD-like changes) which should be considered when using this model as a tool in translational sAD research.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Neural Transmission
Numberingvol. 122, no. 4, pp. 565-576
p-ISSN0300-9564
DOIhttps://doi.org/10.1007/s00702-014-1323-y
URN:NBNurn:nbn:hr:105:181257
Publication2015-04
Document URLhttps://doi.org/10.1007/s00702-014-1323-y
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:33:32