prikaz prve stranice dokumenta Morphological maturation of the mouse brain: an in vivo MRI and histology investigation
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Scientific paper - Original scientific paper
Morphological maturation of the mouse brain: an in vivo MRI and histology investigation
NeuroImage, 125 (2016); 144-152. https://doi.org/10.1016/j.neuroimage.2015.10.009
Hammelrath, Luam; Škokić, Siniša; Khmelinskii, Artem; Hess, Andreas; van der Knaap, Noortje; Staring, Marius; Lelieveldt, Boudewijn P. F.; Wiedermann, Dirk; Hoehn, Mathias

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Hammelrath, L., Škokić, S., Khmelinskii, A., Hess, A., van der Knaap, N., Staring, M. ... Hoehn, M. (2016). Morphological maturation of the mouse brain: an in vivo MRI and histology investigation. NeuroImage, 125., 144-152. doi: 10.1016/j.neuroimage.2015.10.009

Hammelrath, Luam, et al. "Morphological maturation of the mouse brain: an in vivo MRI and histology investigation." NeuroImage, vol. 125, 2016, pp. 144-152. https://doi.org/10.1016/j.neuroimage.2015.10.009

Hammelrath, Luam, Siniša Škokić, Artem Khmelinskii, Andreas Hess, Noortje van der Knaap, Marius Staring, Boudewijn P. F. Lelieveldt, Dirk Wiedermann and Mathias Hoehn. "Morphological maturation of the mouse brain: an in vivo MRI and histology investigation." NeuroImage 125 (2016): 144-152. https://doi.org/10.1016/j.neuroimage.2015.10.009

Hammelrath, L., et al. (2016) 'Morphological maturation of the mouse brain: an in vivo MRI and histology investigation', NeuroImage, 125, pp. 144-152. doi: 10.1016/j.neuroimage.2015.10.009

Hammelrath L, Škokić S, Khmelinskii A, Hess A, van der Knaap N, Staring M, and sur.. Morphological maturation of the mouse brain: an in vivo MRI and histology investigation. NeuroImage [Internet]. 2016 January 15 [cited 2024 November 30];125:144-152. doi: 10.1016/j.neuroimage.2015.10.009

L. Hammelrath, et al., "Morphological maturation of the mouse brain: an in vivo MRI and histology investigation", NeuroImage, vol. 125, pp. 144-152, January 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:456676. [Accessed: 30 November 2024]

Metadata
Title (english)Morphological maturation of the mouse brain: an in vivo MRI and histology investigation
AuthorLuam Hammelrath
AuthorSiniša Škokić
AuthorArtem Khmelinskii
AuthorAndreas Hess
AuthorNoortje van der Knaap
AuthorMarius Staring
AuthorBoudewijn P. F. Lelieveldt
AuthorDirk Wiedermann
AuthorMathias Hoehn
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
With the wide access to studies of selected gene expressions in transgenic animals, mice have become the dominant species as cerebral disease models. Many of these studies are performed on animals of not more than eight weeks, declared as adult animals. Based on the earlier reports that full brain maturation requires at least three months in rats, there is a clear need to discern the corresponding minimal animal age to provide an "adult brain" in mice in order to avoid modulation of disease progression/therapy studies by ongoing developmental changes. For this purpose, we have studied anatomical brain alterations of mice during their first six months of age. Using T2-weighted and diffusion-weighted MRI, structural and volume changes of the brain were identified and compared with histological analysis of myelination. Mouse brain volume was found to be almost stable already at three weeks, but cortex thickness kept decreasing continuously with maximal changes during the first three months. Myelination is still increasing between three and six months, although most dramatic changes are over by three months. While our results emphasize that mice should be at least three months old when adult animals are needed for brain studies, preferred choice of one particular metric for future investigation goals will result in somewhat varying age windows of stabilization.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleNeuroImage
Numberingvol. 125, pp. 144-152
p-ISSN1053-8119
DOIhttps://doi.org/10.1016/j.neuroimage.2015.10.009
URN:NBNurn:nbn:hr:105:456676
Publication2016-01-15
Document URLhttps://doi.org/10.1016/j.neuroimage.2015.10.009
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:34:14