prikaz prve stranice dokumenta Clinical application of genotype-guided dosing of warfarin in patients with acute stroke
  Download
PDF 454.07 KB
Scientific paper - Original scientific paper
Clinical application of genotype-guided dosing of warfarin in patients with acute stroke
Archives of Medical Research, 46 (2015), 4; 265-273. https://doi.org/10.1016/j.arcmed.2015.05.001
Šupe, Svjetlana; Poljaković, Zdravka; Božina, Tamara; Ljevak, Josip; Macolić Šarinić, Viola; Božina, Nada

Institutional repository: Dr Med - University of Zagreb School of Medicine Digital Repository

Cite this document

Šupe, S., Poljaković, Z., Božina, T., Ljevak, J., Macolić Šarinić, V. & Božina, N. (2015). Clinical application of genotype-guided dosing of warfarin in patients with acute stroke. Archives of Medical Research, 46. (4), 265-273. doi: 10.1016/j.arcmed.2015.05.001

Šupe, Svjetlana, et al. "Clinical application of genotype-guided dosing of warfarin in patients with acute stroke." Archives of Medical Research, vol. 46, no. 4, 2015, pp. 265-273. https://doi.org/10.1016/j.arcmed.2015.05.001

Šupe, Svjetlana, Zdravka Poljaković, Tamara Božina, Josip Ljevak, Viola Macolić Šarinić and Nada Božina. "Clinical application of genotype-guided dosing of warfarin in patients with acute stroke." Archives of Medical Research 46, no. 4 (2015): 265-273. https://doi.org/10.1016/j.arcmed.2015.05.001

Šupe, S., et al. (2015) 'Clinical application of genotype-guided dosing of warfarin in patients with acute stroke', Archives of Medical Research, 46(4), pp. 265-273. doi: 10.1016/j.arcmed.2015.05.001

Šupe S, Poljaković Z, Božina T, Ljevak J, Macolić Šarinić V, Božina N. Clinical application of genotype-guided dosing of warfarin in patients with acute stroke. Archives of Medical Research [Internet]. 2015 May [cited 2024 November 05];46(4):265-273. doi: 10.1016/j.arcmed.2015.05.001

S. Šupe, Z. Poljaković, T. Božina, J. Ljevak, V. Macolić Šarinić and N. Božina, "Clinical application of genotype-guided dosing of warfarin in patients with acute stroke", Archives of Medical Research, vol. 46, no. 4, pp. 265-273, May 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:104568. [Accessed: 05 November 2024]

Metadata
Title (english)Clinical application of genotype-guided dosing of warfarin in patients with acute stroke
AuthorSvjetlana Šupe
AuthorZdravka Poljaković
AuthorTamara Božina
AuthorJosip Ljevak
AuthorViola Macolić Šarinić
AuthorNada Božina
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: Patients with certain types of stroke need urgent anticoagulation and it is extremely important for them to achieve fast and stable anticoagulant effect and receive individualized treatment during the initiation of warfarin therapy. ----- METHODS: We conducted a prospective study among 210 acute stroke patients who had an indication for anticoagulation and compared the impact of CYP2C9 and VKORC1 genotype-guided warfarin dosing (PhG) with fixed dosing (NPhG) on anticoagulation control and clinical outcome between groups. ----- RESULTS: PhG achieved target INR values earlier, i.e., on average in 4.2 (4.1-4.7, 95% CI) days compared to NPhG (5.2 days [4.7-6.4, 95% CI]) (p = 0.0009), spent a higher percentage of time in the therapeutic INR range (76.3% [74.7-78.5, 95% CI] vs. 67.1% [64.5-69.6, 95% CI] in NPhG), and spent less time overdosed (INR > 3.1) (PhG 0.4 [0.1-0.7, 95% CI], NPhG 1.7 [1.1-2.3, 95% CI] days; p >0.000). PhG reached stable maintenance dose faster (10 [9.9-10.7, 95% CI] vs. 13.9 [13.3-14.7, 95% CI] days in controls; p = 0.0049) and had a better clinical outcome in relation to neurological deficit on admission as compared to NPhG. ----- CONCLUSION: We confirmed that warfarin therapy with genotype-guided dosing instead of fixed dosing reduces the time required for stabilization and improves anticoagulant control with better clinical outcome in early stages of warfarin therapy introduction among acute stroke patients, which is essential for clinical practice.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleArchives of Medical Research
Numberingvol. 46, no. 4, pp. 265-273
p-ISSN0188-4409
DOIhttps://doi.org/10.1016/j.arcmed.2015.05.001
URN:NBNurn:nbn:hr:105:104568
Publication2015-05
Document URLhttps://doi.org/10.1016/j.arcmed.2015.05.001
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:39:13